| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 18,126,264 | 225,490,000 | 10.38% | ||
| 2 | WELLINGTON MANAGEMENT GROUP LLP | 17,521,066 | 217,962,000 | 10.03% | ||
| 3 | VANGUARD GROUP INC | 14,591,103 | 181,513,000 | 8.35% | ||
| 4 | Sarissa Capital Management LP | 12,850,000 | 159,853,000 | 7.36% | ||
| 5 | BlackRock Fund Advisors | 8,959,423 | 111,455,000 | 5.13% | ||
| 6 | STATE STREET CORP | 7,869,172 | 97,892,000 | 4.50% | ||
| 7 | PUTNAM INVESTMENTS LLC | 7,822,704 | 97,314,000 | 4.48% | ||
| 8 | PRICE T ROWE ASSOCIATES INC /MD/ | 5,451,998 | 67,823,000 | 3.12% | ||
| 9 | WESTFIELD CAPITAL MANAGEMENT CO LP | 4,957,058 | 61,666,000 | 2.84% | ||
| 10 | PointState Capital LP | 4,946,800 | 61,538,000 | 2.83% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 4,862,195 | 60,486,000 | 2.78% | ||
| 12 | Redmile Group, LLC | 3,838,376 | 47,749,000 | 2.20% | ||
| 13 | Consonance Capital Management LP | 3,553,943 | 44,211,000 | 2.03% | ||
| 14 | ALLIANCEBERNSTEIN L.P. | 3,512,570 | 43,696,000 | 2.01% | ||
| 15 | Palo Alto Investors LP | 2,682,017 | 33,364,000 | 1.54% | ||
| 16 | NORGES BANK | 2,339,750 | 29,107,000 | 1.34% | ||
| 17 | TimesSquare Capital Management, LLC | 2,237,365 | 27,833,000 | 1.28% | ||
| 18 | NORTHERN TRUST CORP | 2,093,677 | 26,045,000 | 1.20% | ||
| 19 | OppenheimerFunds, Inc. | 1,870,370 | 23,267,000 | 1.07% | ||
| 20 | TWO SIGMA INVESTMENTS, LP | 1,834,011 | 22,815,000 | 1.05% | ||
| 21 | LORD, ABBETT & CO. LLC | 1,792,326 | 22,297,000 | 1.03% | ||
| 22 | JENNISON ASSOCIATES LLC | 1,660,288 | 20,654,000 | 0.95% | ||
| 23 | GEODE CAPITAL MANAGEMENT, LLC | 1,534,851 | 19,093,000 | 0.88% | ||
| 24 | PICTET ASSET MANAGEMENT LTD | 1,515,257 | 18,850,000 | 0.87% | ||
| 25 | AMERIPRISE FINANCIAL INC | 1,439,502 | 17,910,000 | 0.82% | ||
| 26 | GOLDMAN SACHS GROUP INC | 1,394,100 | 17,342,000 | 0.80% | ||
| 27 | Polar Capital LLP | 1,235,000 | 15,363,000 | 0.71% | ||
| 28 | DEUTSCHE BANK AG\ | 1,225,891 | 15,247,000 | 0.70% | ||
| 29 | MORGAN STANLEY | 1,076,629 | 13,393,000 | 0.62% | ||
| 30 | Bank of New York Mellon Corp | 1,005,186 | 12,504,000 | 0.58% | ||
| 31 | Opaleye Management Inc. | 1,000,000 | 12,440,000 | 0.57% | ||
| 32 | HBK INVESTMENTS L P | 947,249 | 11,784,000 | 0.54% | ||
| 33 | PRICE MICHAEL F | 940,000 | 11,694,000 | 0.54% | ||
| 34 | Nantahala Capital Management, LLC | 900,000 | 11,196,000 | 0.52% | Put | |
| 35 | Rhenman & Partners Asset Management AB | 895,000 | 11,134,000 | 0.51% | ||
| 36 | TAMARACK ADVISERS, LP | 850,000 | 10,574,000 | 0.49% | ||
| 37 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 778,437 | 9,684,000 | 0.45% | ||
| 38 | CITIGROUP INC | 777,786 | 9,675,000 | 0.45% | ||
| 39 | RENAISSANCE TECHNOLOGIES LLC | 762,481 | 9,485,000 | 0.44% | ||
| 40 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 755,600 | 9,400,000 | 0.43% | Call | |
| 41 | GENERAL AMERICAN INVESTORS CO INC | 714,100 | 8,883,000 | 0.41% | ||
| 42 | BlackRock Investment Management, LLC | 667,499 | 8,304,000 | 0.38% | ||
| 43 | INTERNATIONAL BIOTECHNOLOGY TRUST PLC | 657,912 | 8,184,000 | 0.38% | ||
| 44 | HighVista Strategies LLC | 638,086 | 7,938,000 | 0.37% | ||
| 45 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 614,700 | 7,647,000 | 0.35% | Put | |
| 46 | COMMERZBANK AKTIENGESELLSCHAFT /FI | 612,886 | 7,624,000 | 0.35% | ||
| 47 | VOLORIDGE INVESTMENT MANAGEMENT, LLC | 601,463 | 7,482,000 | 0.34% | ||
| 48 | TWO SIGMA ADVISERS, LP | 568,749 | 7,075,000 | 0.33% | ||
| 49 | Elk Creek Partners, LLC | 543,063 | 6,756,000 | 0.31% | ||
| 50 | TIAA CREF INVESTMENT MANAGEMENT LLC | 509,592 | 6,339,000 | 0.29% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
