| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | PUTNAM INVESTMENTS LLC | 15,144,545 | 111,918,000 | 10.60% | ||
| 2 | Sarissa Capital Management LP | 12,850,000 | 94,961,000 | 8.99% | ||
| 3 | VANGUARD GROUP INC | 12,724,399 | 94,033,000 | 8.90% | ||
| 4 | WESTFIELD CAPITAL MANAGEMENT CO LP | 10,575,638 | 78,154,000 | 7.40% | ||
| 5 | Consonance Capital Management LP | 8,845,742 | 65,370,000 | 6.19% | ||
| 6 | BlackRock Fund Advisors | 7,832,019 | 57,879,000 | 5.48% | ||
| 7 | FMR LLC | 6,130,056 | 45,300,000 | 4.29% | ||
| 8 | STATE STREET CORP | 5,795,195 | 42,831,000 | 4.06% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 4,546,501 | 33,599,000 | 3.18% | ||
| 10 | Camber Capital Management LP | 4,000,000 | 29,560,000 | 2.80% | ||
| 11 | PointState Capital LP | 3,800,000 | 28,082,000 | 2.66% | ||
| 12 | Palo Alto Investors LP | 2,535,117 | 18,735,000 | 1.77% | ||
| 13 | NORTHERN TRUST CORP | 2,219,448 | 16,401,000 | 1.55% | ||
| 14 | TAMARACK ADVISERS, LP | 2,100,000 | 15,519,000 | 1.47% | ||
| 15 | Elk Creek Partners, LLC | 2,052,525 | 15,168,000 | 1.44% | ||
| 16 | NORGES BANK | 2,043,993 | 15,105,000 | 1.43% | ||
| 17 | OppenheimerFunds, Inc. | 1,860,860 | 13,752,000 | 1.30% | ||
| 18 | GOLDMAN SACHS GROUP INC | 1,769,235 | 13,075,000 | 1.24% | ||
| 19 | Jupiter Investment Management Ltd | 1,518,921 | 11,224,000 | 1.06% | ||
| 20 | HBK INVESTMENTS L P | 1,495,300 | 11,050,000 | 1.05% | ||
| 21 | GEODE CAPITAL MANAGEMENT, LLC | 1,321,202 | 9,763,000 | 0.92% | ||
| 22 | Opaleye Management Inc. | 1,250,000 | 9,238,000 | 0.87% | ||
| 23 | GENERAL AMERICAN INVESTORS CO INC | 1,200,000 | 8,868,000 | 0.84% | ||
| 24 | CQS Cayman LP | 1,132,000 | 8,365,000 | 0.79% | ||
| 25 | PRICE MICHAEL F | 1,075,000 | 7,944,000 | 0.75% | ||
| 26 | Bank of New York Mellon Corp | 1,035,881 | 7,655,000 | 0.72% | ||
| 27 | DEUTSCHE BANK AG\ | 965,954 | 7,135,000 | 0.68% | ||
| 28 | HighVista Strategies LLC | 869,100 | 6,423,000 | 0.61% | ||
| 29 | Invesco Ltd. | 857,630 | 6,338,000 | 0.60% | ||
| 30 | MORGAN STANLEY | 812,116 | 6,002,000 | 0.57% | ||
| 31 | JS Capital Management LLC | 807,700 | 5,969,000 | 0.57% | ||
| 32 | OXFORD ASSET MANAGEMENT LLP | 758,519 | 5,605,000 | 0.53% | ||
| 33 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 674,330 | 4,984,000 | 0.47% | ||
| 34 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 667,200 | 4,931,000 | 0.47% | Call | |
| 35 | BlackRock Investment Management, LLC | 664,847 | 4,913,000 | 0.47% | ||
| 36 | COMMERZBANK AKTIENGESELLSCHAFT /FI | 629,194 | 4,650,000 | 0.44% | ||
| 37 | Rhenman & Partners Asset Management AB | 625,000 | 4,619,000 | 0.44% | ||
| 38 | PDT Partners, LLC | 618,187 | 4,568,000 | 0.43% | ||
| 39 | TIAA CREF INVESTMENT MANAGEMENT LLC | 576,678 | 4,262,000 | 0.40% | ||
| 40 | Parallax Volatility Advisers, L.P. | 570,000 | 4,213,000 | 0.40% | Put | |
| 41 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 562,361 | 4,156,000 | 0.39% | ||
| 42 | JPMORGAN CHASE & CO | 540,754 | 3,996,000 | 0.38% | ||
| 43 | Tekla Capital Management LLC | 502,000 | 3,710,000 | 0.35% | ||
| 44 | CADIAN CAPITAL MANAGEMENT, LP | 500,000 | 3,695,000 | 0.35% | ||
| 45 | BELLEVUE GROUP AG | 495,000 | 3,658,000 | 0.35% | ||
| 46 | ALLIANCEBERNSTEIN L.P. | 476,585 | 3,522,000 | 0.33% | ||
| 47 | A.R.T. Advisors, LLC | 438,817 | 3,242,000 | 0.31% | ||
| 48 | Granite Point Capital Management, L.P. | 430,890 | 3,184,000 | 0.30% | ||
| 49 | ROYCE & ASSOCIATES LP | 375,352 | 2,774,000 | 0.26% | ||
| 50 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 371,038 | 2,742,000 | 0.26% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
