| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 8,992,381 | 95,139,000 | 20.00% | ||
| 2 | BAKER BROS. ADVISORS LP | 5,867,031 | 62,073,000 | 13.05% | ||
| 3 | RA CAPITAL MANAGEMENT, L.P. | 4,347,456 | 45,996,000 | 9.67% | ||
| 4 | WELLINGTON MANAGEMENT GROUP LLP | 4,019,761 | 42,529,000 | 8.94% | ||
| 5 | D. E. Shaw & Co., Inc. | 2,069,060 | 21,891,000 | 4.60% | ||
| 6 | VANGUARD GROUP INC | 1,784,623 | 18,881,000 | 3.97% | ||
| 7 | VHCP Management, LLC | 1,744,356 | 18,455,000 | 3.88% | ||
| 8 | STATE STREET CORP | 1,638,419 | 17,334,000 | 3.64% | ||
| 9 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,583,000 | 16,748,000 | 3.52% | ||
| 10 | Cormorant Asset Management, LP | 1,168,000 | 12,357,000 | 2.60% | ||
| 11 | TPG Group Holdings (SBS) Advisors, Inc. | 1,162,269 | 12,297,000 | 2.58% | ||
| 12 | BlackRock Institutional Trust Company, N.A. | 1,079,396 | 11,420,000 | 2.40% | ||
| 13 | DEERFIELD MANAGEMENT COMPANY, L.P. | 907,920 | 9,606,000 | 2.02% | ||
| 14 | BlackRock Fund Advisors | 898,132 | 9,502,000 | 2.00% | ||
| 15 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 837,400 | 8,860,000 | 1.86% | Call | |
| 16 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 632,700 | 6,694,000 | 1.41% | Put | |
| 17 | MILLENNIUM MANAGEMENT LLC | 589,752 | 6,240,000 | 1.31% | ||
| 18 | Connor, Clark & Lunn Investment Management Ltd. | 528,098 | 6,167,000 | 1.30% | ||
| 19 | QVT Financial LP | 525,734 | 5,562,000 | 1.17% | ||
| 20 | MORGAN STANLEY | 525,306 | 5,559,000 | 1.17% | ||
| 21 | JENNISON ASSOCIATES LLC | 358,557 | 3,794,000 | 0.80% | ||
| 22 | THB ASSET MANAGEMENT | 301,529 | 3,190,000 | 0.67% | ||
| 23 | GEODE CAPITAL MANAGEMENT, LLC | 278,664 | 2,948,000 | 0.62% | ||
| 24 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 274,667 | 2,906,000 | 0.61% | ||
| 25 | PANAGORA ASSET MANAGEMENT INC | 246,190 | 2,605,000 | 0.55% | ||
| 26 | JANE STREET GROUP, LLC | 180,460 | 1,909,000 | 0.40% | ||
| 27 | UBS AG | 165,035 | 1,746,000 | 0.37% | ||
| 28 | CREDIT SUISSE AG/ | 139,758 | 1,479,000 | 0.31% | ||
| 29 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 144,500 | 1,366,000 | 0.29% | ||
| 30 | NORTHERN TRUST CORP | 114,904 | 1,215,000 | 0.26% | ||
| 31 | Informed Momentum Co LLC | 114,548 | 1,212,000 | 0.25% | ||
| 32 | AQR CAPITAL MANAGEMENT LLC | 111,762 | 1,182,000 | 0.25% | ||
| 33 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 102,706 | 1,087,000 | 0.23% | ||
| 34 | A.R.T. Advisors, LLC | 100,239 | 1,060,000 | 0.22% | ||
| 35 | DEUTSCHE BANK AG\ | 93,221 | 985,000 | 0.21% | ||
| 36 | Bank of New York Mellon Corp | 91,135 | 964,000 | 0.20% | ||
| 37 | RENAISSANCE TECHNOLOGIES LLC | 90,514 | 958,000 | 0.20% | ||
| 38 | BANK OF AMERICA CORP /DE/ | 84,300 | 892,000 | 0.19% | ||
| 39 | Airain ltd | 62,306 | 659,000 | 0.14% | ||
| 40 | SOROS FUND MANAGEMENT LLC | 59,700 | 632,000 | 0.13% | ||
| 41 | Swiss National Bank | 55,200 | 584,000 | 0.12% | ||
| 42 | RUSSELL FRANK CO/ | 71,428 | 581,000 | 0.12% | ||
| 43 | DEERE & CO | 53,520 | 566,000 | 0.12% | ||
| 44 | Spark Investment Management LLC | 53,100 | 561,000 | 0.12% | ||
| 45 | ProShare Advisors LLC | 45,235 | 479,000 | 0.10% | ||
| 46 | Commonwealth Equity Services, Inc | 43,323 | 458,000 | 0.10% | ||
| 47 | PDT Partners, LLC | 39,974 | 423,000 | 0.09% | ||
| 48 | WELLS FARGO & COMPANY/MN | 39,510 | 418,000 | 0.09% | ||
| 49 | DekaBank Deutsche Girozentrale | 36,500 | 386,000 | 0.08% | ||
| 50 | BARCLAYS PLC | 35,800 | 358,000 | 0.08% | Call |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
