| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 10,963,944 | 48,351,000 | 18.70% | ||
| 2 | VHCP MANAGEMENT II, LLC | 5,721,142 | 25,230,000 | 9.76% | ||
| 3 | DEERFIELD MANAGEMENT COMPANY, L.P. | 4,401,846 | 19,412,000 | 7.51% | ||
| 4 | RTW INVESTMENTS, LP | 4,204,579 | 18,542,000 | 7.17% | ||
| 5 | D. E. Shaw & Co., Inc. | 3,664,867 | 16,162,000 | 6.25% | ||
| 6 | VANGUARD GROUP INC | 3,556,486 | 15,684,000 | 6.06% | ||
| 7 | BlackRock Fund Advisors | 3,027,595 | 13,352,000 | 5.16% | ||
| 8 | RA CAPITAL MANAGEMENT, L.P. | 2,989,795 | 13,185,000 | 5.10% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 1,956,570 | 8,628,000 | 3.34% | ||
| 10 | Ghost Tree Capital, LLC | 1,800,000 | 7,938,000 | 3.07% | ||
| 11 | Avoro Capital Advisors LLC | 1,379,402 | 6,083,000 | 2.35% | ||
| 12 | JENNISON ASSOCIATES LLC | 1,351,330 | 5,959,000 | 2.30% | ||
| 13 | STATE STREET CORP | 1,348,308 | 5,945,000 | 2.30% | ||
| 14 | VHCP Management, LLC | 1,005,104 | 4,433,000 | 1.71% | ||
| 15 | Invesco Ltd. | 967,292 | 4,266,000 | 1.65% | ||
| 16 | GOLDMAN SACHS GROUP INC | 896,742 | 3,955,000 | 1.53% | ||
| 17 | NORTHERN TRUST CORP | 855,991 | 3,775,000 | 1.46% | ||
| 18 | GREAT POINT PARTNERS LLC | 725,000 | 3,197,000 | 1.24% | Put | |
| 19 | ACUTA CAPITAL PARTNERS, LLC | 554,448 | 2,445,000 | 0.95% | ||
| 20 | DEUTSCHE BANK AG\ | 517,597 | 2,281,000 | 0.88% | ||
| 21 | GEODE CAPITAL MANAGEMENT, LLC | 499,502 | 2,202,000 | 0.85% | ||
| 22 | TIAA CREF INVESTMENT MANAGEMENT LLC | 385,339 | 1,699,000 | 0.66% | ||
| 23 | PAULSON & CO. INC. | 363,100 | 1,601,000 | 0.62% | ||
| 24 | Bank of New York Mellon Corp | 318,879 | 1,406,000 | 0.54% | ||
| 25 | MILLENNIUM MANAGEMENT LLC | 300,000 | 1,323,000 | 0.51% | Call | |
| 26 | BlackRock Investment Management, LLC | 295,020 | 1,301,000 | 0.50% | ||
| 27 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 292,500 | 1,290,000 | 0.50% | Put | |
| 28 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 257,183 | 1,135,000 | 0.44% | ||
| 29 | FMR LLC | 239,562 | 1,056,000 | 0.41% | ||
| 30 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 176,962 | 780,000 | 0.30% | ||
| 31 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 171,000 | 754,000 | 0.29% | Call | |
| 32 | PDT Partners, LLC | 161,900 | 714,000 | 0.28% | ||
| 33 | ROYCE & ASSOCIATES LP | 160,000 | 706,000 | 0.27% | ||
| 34 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 155,483 | 686,000 | 0.27% | ||
| 35 | WOLVERINE TRADING LP /BD | 127,100 | 566,000 | 0.22% | Put | |
| 36 | ALLIANCEBERNSTEIN L.P. | 126,220 | 557,000 | 0.22% | ||
| 37 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 123,400 | 544,000 | 0.21% | ||
| 38 | BARCLAYS PLC | 114,400 | 505,000 | 0.20% | Call | |
| 39 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 112,801 | 497,000 | 0.19% | ||
| 40 | CREDIT SUISSE AG/ | 111,405 | 492,000 | 0.19% | ||
| 41 | ACUTA CAPITAL PARTNERS, LLC | 107,200 | 473,000 | 0.18% | Call | |
| 42 | TEACHERS ADVISORS, LLC | 106,162 | 468,000 | 0.18% | ||
| 43 | Amici Capital, LLC | 100,000 | 441,000 | 0.17% | ||
| 44 | Swiss National Bank | 96,300 | 425,000 | 0.16% | ||
| 45 | CORRADO ADVISORS, LLC | 95,170 | 420,000 | 0.16% | ||
| 46 | UBS Group AG | 88,256 | 389,000 | 0.15% | ||
| 47 | VIRTUS ETF ADVISERS LLC | 84,907 | 374,000 | 0.14% | ||
| 48 | RHUMBLINE ADVISERS | 81,310 | 359,000 | 0.14% | ||
| 49 | FEDERATED HERMES, INC. | 80,852 | 357,000 | 0.14% | ||
| 50 | WOLVERINE TRADING LP /BD | 73,600 | 328,000 | 0.13% | Call |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
