| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 14,217,779 | 146,727,000 | 22.31% | ||
| 2 | FMR LLC | 7,488,027 | 77,277,000 | 11.75% | ||
| 3 | WELLINGTON MANAGEMENT GROUP LLP | 7,470,439 | 77,096,000 | 11.72% | ||
| 4 | RA CAPITAL MANAGEMENT, L.P. | 3,094,064 | 31,931,000 | 4.85% | ||
| 5 | VANGUARD GROUP INC | 2,809,038 | 28,989,000 | 4.41% | ||
| 6 | BlackRock Fund Advisors | 2,789,584 | 28,789,000 | 4.38% | ||
| 7 | D. E. Shaw & Co., Inc. | 2,567,215 | 26,494,000 | 4.03% | ||
| 8 | STATE STREET CORP | 2,114,768 | 21,823,000 | 3.32% | ||
| 9 | RTW INVESTMENTS, LP | 1,973,108 | 20,362,000 | 3.10% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 1,805,315 | 18,631,000 | 2.83% | ||
| 11 | FRANKLIN RESOURCES INC | 1,658,217 | 17,113,000 | 2.60% | ||
| 12 | QVT Financial LP | 1,358,097 | 14,016,000 | 2.13% | ||
| 13 | JENNISON ASSOCIATES LLC | 1,348,563 | 13,917,000 | 2.12% | ||
| 14 | Invesco Ltd. | 1,106,873 | 11,423,000 | 1.74% | ||
| 15 | GOLDMAN SACHS GROUP INC | 1,082,285 | 11,169,000 | 1.70% | ||
| 16 | Cormorant Asset Management, LP | 1,080,000 | 11,146,000 | 1.69% | ||
| 17 | NORTHERN TRUST CORP | 903,786 | 9,327,000 | 1.42% | ||
| 18 | PRICE T ROWE ASSOCIATES INC /MD/ | 750,100 | 7,741,000 | 1.18% | ||
| 19 | AXA S.A. | 634,873 | 6,552,000 | 1.00% | ||
| 20 | GEODE CAPITAL MANAGEMENT, LLC | 476,652 | 4,919,000 | 0.75% | ||
| 21 | TEACHERS ADVISORS, LLC | 418,134 | 4,315,000 | 0.66% | ||
| 22 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 358,100 | 3,696,000 | 0.56% | Call | |
| 23 | TIAA CREF INVESTMENT MANAGEMENT LLC | 326,873 | 3,373,000 | 0.51% | ||
| 24 | Bank of New York Mellon Corp | 325,140 | 3,355,000 | 0.51% | ||
| 25 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 266,600 | 2,751,000 | 0.42% | Put | |
| 26 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 265,970 | 2,745,000 | 0.42% | ||
| 27 | BlackRock Investment Management, LLC | 257,682 | 2,659,000 | 0.40% | ||
| 28 | DAFNA Capital Management LLC | 255,642 | 2,638,000 | 0.40% | SH | |
| 29 | Connor, Clark & Lunn Investment Management Ltd. | 206,573 | 2,132,000 | 0.32% | ||
| 30 | PUTNAM INVESTMENTS LLC | 199,100 | 2,055,000 | 0.31% | ||
| 31 | MILLENNIUM MANAGEMENT LLC | 173,252 | 1,788,000 | 0.27% | ||
| 32 | SABBY MANAGEMENT, LLC | 165,529 | 1,708,000 | 0.26% | ||
| 33 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 159,260 | 1,644,000 | 0.25% | ||
| 34 | SIT INVESTMENT ASSOCIATES INC | 150,175 | 1,550,000 | 0.24% | ||
| 35 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 144,500 | 1,491,000 | 0.23% | ||
| 36 | RENAISSANCE TECHNOLOGIES LLC | 142,903 | 1,475,000 | 0.22% | ||
| 37 | UBS Group AG | 141,403 | 1,459,000 | 0.22% | ||
| 38 | MACQUARIE GROUP LTD | 139,248 | 1,437,000 | 0.22% | ||
| 39 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 134,426 | 1,387,000 | 0.21% | ||
| 40 | ALLIANCEBERNSTEIN L.P. | 118,950 | 1,356,000 | 0.21% | ||
| 41 | Nationwide Fund Advisors | 130,148 | 1,343,000 | 0.20% | ||
| 42 | GLOBEFLEX CAPITAL L P | 120,296 | 1,241,000 | 0.19% | ||
| 43 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 115,116 | 1,188,000 | 0.18% | ||
| 44 | CORRADO ADVISORS, LLC | 107,895 | 1,113,000 | 0.17% | ||
| 45 | MORGAN STANLEY | 103,804 | 1,071,000 | 0.16% | ||
| 46 | DEUTSCHE BANK AG\ | 100,565 | 1,035,000 | 0.16% | ||
| 47 | Opus Point Partners Management, LLC | 100,000 | 1,032,000 | 0.16% | ||
| 48 | ALPS ADVISORS INC | 96,610 | 997,000 | 0.15% | ||
| 49 | Spark Investment Management LLC | 87,600 | 904,000 | 0.14% | ||
| 50 | RHUMBLINE ADVISERS | 82,832 | 855,000 | 0.13% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
