| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 15,010,534 | 42,480,000 | 27.02% | ||
| 2 | VHCP MANAGEMENT II, LLC | 4,689,435 | 13,271,000 | 8.44% | ||
| 3 | D. E. Shaw & Co., Inc. | 4,055,066 | 11,475,000 | 7.30% | ||
| 4 | VANGUARD GROUP INC | 3,243,328 | 9,179,000 | 5.84% | ||
| 5 | RA CAPITAL MANAGEMENT, L.P. | 2,989,795 | 8,461,000 | 5.38% | ||
| 6 | BlackRock Fund Advisors | 2,800,786 | 7,926,000 | 5.04% | ||
| 7 | RTW INVESTMENTS, LP | 1,973,932 | 5,586,000 | 3.55% | ||
| 8 | BlackRock Institutional Trust Company, N.A. | 1,868,245 | 5,287,000 | 3.36% | ||
| 9 | FRANKLIN RESOURCES INC | 1,658,217 | 4,693,000 | 2.98% | ||
| 10 | WELLINGTON MANAGEMENT GROUP LLP | 1,496,859 | 4,236,000 | 2.69% | ||
| 11 | JENNISON ASSOCIATES LLC | 1,357,604 | 3,842,000 | 2.44% | ||
| 12 | STATE STREET CORP | 1,343,332 | 3,802,000 | 2.42% | ||
| 13 | GOLDMAN SACHS GROUP INC | 1,237,418 | 3,502,000 | 2.23% | ||
| 14 | Cormorant Asset Management, LP | 1,080,000 | 3,056,000 | 1.94% | ||
| 15 | FMR LLC | 1,000,000 | 2,830,000 | 1.80% | ||
| 16 | NORTHERN TRUST CORP | 832,663 | 2,357,000 | 1.50% | ||
| 17 | VHCP Management, LLC | 562,943 | 1,593,000 | 1.01% | ||
| 18 | Spark Investment Management LLC | 530,100 | 1,500,000 | 0.95% | ||
| 19 | GEODE CAPITAL MANAGEMENT, LLC | 501,983 | 1,419,000 | 0.90% | ||
| 20 | TANG CAPITAL MANAGEMENT LLC | 430,000 | 1,217,000 | 0.77% | ||
| 21 | A.R.T. Advisors, LLC | 418,308 | 1,183,000 | 0.75% | ||
| 22 | GLOBEFLEX CAPITAL L P | 413,941 | 1,171,000 | 0.74% | ||
| 23 | MILLENNIUM MANAGEMENT LLC | 362,289 | 1,025,000 | 0.65% | ||
| 24 | TIAA CREF INVESTMENT MANAGEMENT LLC | 326,873 | 925,000 | 0.59% | ||
| 25 | Bank of New York Mellon Corp | 307,115 | 869,000 | 0.55% | ||
| 26 | RENAISSANCE TECHNOLOGIES LLC | 292,221 | 827,000 | 0.53% | ||
| 27 | DEUTSCHE BANK AG\ | 289,857 | 817,000 | 0.52% | ||
| 28 | PAULSON & CO. INC. | 263,100 | 745,000 | 0.47% | ||
| 29 | BlackRock Investment Management, LLC | 261,537 | 740,000 | 0.47% | ||
| 30 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 242,201 | 686,000 | 0.44% | ||
| 31 | Connor, Clark & Lunn Investment Management Ltd. | 201,573 | 570,000 | 0.36% | ||
| 32 | MORGAN STANLEY | 180,225 | 510,000 | 0.32% | ||
| 33 | ROYCE & ASSOCIATES LP | 160,000 | 453,000 | 0.29% | ||
| 34 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 153,583 | 435,000 | 0.28% | ||
| 35 | DAFNA Capital Management LLC | 149,642 | 423,000 | 0.27% | ||
| 36 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 136,200 | 385,000 | 0.24% | ||
| 37 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 129,414 | 366,000 | 0.23% | ||
| 38 | TUDOR INVESTMENT CORP ET AL | 125,588 | 355,000 | 0.23% | ||
| 39 | AQR CAPITAL MANAGEMENT LLC | 124,614 | 353,000 | 0.22% | ||
| 40 | CORRADO ADVISORS, LLC | 119,125 | 337,000 | 0.21% | ||
| 41 | ALLIANCEBERNSTEIN L.P. | 118,420 | 335,000 | 0.21% | ||
| 42 | TEACHERS ADVISORS, LLC | 107,034 | 303,000 | 0.19% | ||
| 43 | Quantitative Investment Management, LLC | 103,800 | 293,000 | 0.19% | ||
| 44 | Amici Capital, LLC | 100,000 | 283,000 | 0.18% | ||
| 45 | Swiss National Bank | 96,300 | 263,000 | 0.17% | ||
| 46 | RHUMBLINE ADVISERS | 86,077 | 244,000 | 0.16% | ||
| 47 | CREDIT SUISSE AG/ | 84,919 | 242,000 | 0.15% | ||
| 48 | Nationwide Fund Advisors | 84,469 | 238,000 | 0.15% | ||
| 49 | ALPS ADVISORS INC | 82,476 | 233,000 | 0.15% | ||
| 50 | UBS Group AG | 72,835 | 206,000 | 0.13% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
