| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 11,577,299 | 172,849,000 | 18.19% | ||
| 2 | FMR LLC | 9,644,931 | 143,999,000 | 15.16% | ||
| 3 | WELLINGTON MANAGEMENT GROUP LLP | 6,981,571 | 104,235,000 | 10.97% | ||
| 4 | STATE STREET CORP | 3,210,208 | 47,927,000 | 5.04% | ||
| 5 | BlackRock Fund Advisors | 2,823,718 | 42,158,000 | 4.44% | ||
| 6 | RA CAPITAL MANAGEMENT, L.P. | 2,605,361 | 38,898,000 | 4.09% | ||
| 7 | VANGUARD GROUP INC | 2,469,727 | 36,873,000 | 3.88% | ||
| 8 | RTW INVESTMENTS, LP | 2,261,361 | 33,762,000 | 3.55% | ||
| 9 | D. E. Shaw & Co., Inc. | 2,168,252 | 32,372,000 | 3.41% | ||
| 10 | MILLENNIUM MANAGEMENT LLC | 1,917,021 | 28,621,000 | 3.01% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 1,823,953 | 27,232,000 | 2.87% | ||
| 12 | JENNISON ASSOCIATES LLC | 1,317,717 | 19,674,000 | 2.07% | ||
| 13 | QVT Financial LP | 1,171,897 | 17,496,000 | 1.84% | ||
| 14 | GOLDMAN SACHS GROUP INC | 1,033,164 | 15,425,000 | 1.62% | ||
| 15 | CITADEL ADVISORS LLC | 794,591 | 11,863,000 | 1.25% | ||
| 16 | NORTHERN TRUST CORP | 761,045 | 11,363,000 | 1.20% | ||
| 17 | FRANKLIN RESOURCES INC | 748,719 | 11,178,000 | 1.18% | ||
| 18 | Cormorant Asset Management, LP | 680,000 | 10,152,000 | 1.07% | ||
| 19 | LORD, ABBETT & CO. LLC | 547,679 | 8,176,000 | 0.86% | ||
| 20 | PERCEPTIVE ADVISORS LLC | 470,000 | 7,017,000 | 0.74% | ||
| 21 | GEODE CAPITAL MANAGEMENT, LLC | 406,016 | 6,061,000 | 0.64% | ||
| 22 | Bank of New York Mellon Corp | 391,890 | 5,851,000 | 0.62% | ||
| 23 | VHCP Management, LLC | 373,686 | 5,579,000 | 0.59% | ||
| 24 | BLACKROCK ADVISORS LLC | 360,593 | 5,383,000 | 0.57% | ||
| 25 | TIAA CREF INVESTMENT MANAGEMENT LLC | 350,731 | 5,236,000 | 0.55% | ||
| 26 | AXA S.A. | 350,328 | 5,230,000 | 0.55% | ||
| 27 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 284,500 | 4,248,000 | 0.45% | Call | |
| 28 | JPMORGAN CHASE & CO | 281,700 | 4,206,000 | 0.44% | ||
| 29 | BlackRock Investment Management, LLC | 278,397 | 4,156,000 | 0.44% | ||
| 30 | DRIEHAUS CAPITAL MANAGEMENT LLC | 259,361 | 3,872,000 | 0.41% | ||
| 31 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 234,331 | 3,498,000 | 0.37% | ||
| 32 | DAFNA Capital Management LLC | 221,656 | 3,309,000 | 0.35% | SH | |
| 33 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 209,875 | 3,134,000 | 0.33% | ||
| 34 | PUTNAM INVESTMENTS LLC | 199,100 | 2,973,000 | 0.31% | ||
| 35 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 198,400 | 2,962,000 | 0.31% | Put | |
| 36 | CREDIT SUISSE AG/ | 183,309 | 2,737,000 | 0.29% | ||
| 37 | BlackRock Group LTD | 156,557 | 2,338,000 | 0.25% | ||
| 38 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 144,500 | 2,157,000 | 0.23% | ||
| 39 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 137,042 | 2,046,000 | 0.22% | ||
| 40 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 132,450 | 1,977,000 | 0.21% | ||
| 41 | Trexquant Investment LP | 126,300 | 1,885,000 | 0.20% | ||
| 42 | SIT INVESTMENT ASSOCIATES INC | 120,675 | 1,802,000 | 0.19% | ||
| 43 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 119,106 | 1,778,000 | 0.19% | ||
| 44 | ALLIANCEBERNSTEIN L.P. | 118,600 | 1,771,000 | 0.19% | ||
| 45 | Informed Momentum Co LLC | 116,969 | 1,746,000 | 0.18% | ||
| 46 | MACQUARIE GROUP LTD | 113,635 | 1,697,000 | 0.18% | ||
| 47 | TEACHERS ADVISORS, LLC | 105,420 | 1,574,000 | 0.17% | ||
| 48 | BANK OF AMERICA CORP /DE/ | 104,800 | 1,565,000 | 0.16% | Put | |
| 49 | RUSSELL FRANK CO/ | 101,896 | 1,521,000 | 0.16% | ||
| 50 | MORGAN STANLEY | 99,092 | 1,479,000 | 0.16% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
