| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 15,010,534 | 42,630,000 | 28.88% | ||
| 2 | VHCP MANAGEMENT II, LLC | 5,721,142 | 16,248,000 | 11.01% | ||
| 3 | VANGUARD GROUP INC | 3,526,530 | 10,016,000 | 6.79% | ||
| 4 | D. E. Shaw & Co., Inc. | 3,433,652 | 9,752,000 | 6.61% | ||
| 5 | RA CAPITAL MANAGEMENT, L.P. | 2,989,795 | 8,491,000 | 5.75% | ||
| 6 | BlackRock Fund Advisors | 2,850,238 | 8,095,000 | 5.48% | ||
| 7 | RTW INVESTMENTS, LP | 2,237,066 | 6,353,000 | 4.30% | ||
| 8 | BlackRock Institutional Trust Company, N.A. | 1,854,035 | 5,265,000 | 3.57% | ||
| 9 | Ghost Tree Capital, LLC | 1,700,000 | 4,828,000 | 3.27% | ||
| 10 | JENNISON ASSOCIATES LLC | 1,356,302 | 3,852,000 | 2.61% | ||
| 11 | STATE STREET CORP | 1,339,348 | 3,803,000 | 2.58% | ||
| 12 | GOLDMAN SACHS GROUP INC | 1,146,080 | 3,255,000 | 2.21% | ||
| 13 | VHCP Management, LLC | 1,005,104 | 2,854,000 | 1.93% | ||
| 14 | NORTHERN TRUST CORP | 863,925 | 2,454,000 | 1.66% | ||
| 15 | GEODE CAPITAL MANAGEMENT, LLC | 493,440 | 1,401,000 | 0.95% | ||
| 16 | TANG CAPITAL MANAGEMENT LLC | 430,000 | 1,221,000 | 0.83% | ||
| 17 | TIAA CREF INVESTMENT MANAGEMENT LLC | 388,150 | 1,102,000 | 0.75% | ||
| 18 | Bank of New York Mellon Corp | 306,563 | 870,000 | 0.59% | ||
| 19 | GLOBEFLEX CAPITAL L P | 291,941 | 829,000 | 0.56% | ||
| 20 | BlackRock Investment Management, LLC | 278,020 | 790,000 | 0.54% | ||
| 21 | PAULSON & CO. INC. | 263,100 | 747,000 | 0.51% | ||
| 22 | WELLINGTON MANAGEMENT GROUP LLP | 256,120 | 727,000 | 0.49% | ||
| 23 | DEUTSCHE BANK AG\ | 249,725 | 705,000 | 0.48% | ||
| 24 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 245,729 | 698,000 | 0.47% | ||
| 25 | Spark Investment Management LLC | 181,800 | 516,000 | 0.35% | ||
| 26 | FMR LLC | 181,100 | 514,000 | 0.35% | ||
| 27 | ROYCE & ASSOCIATES LP | 160,000 | 454,000 | 0.31% | ||
| 28 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 154,083 | 438,000 | 0.30% | ||
| 29 | ALLIANCEBERNSTEIN L.P. | 136,020 | 386,000 | 0.26% | ||
| 30 | Connor, Clark & Lunn Investment Management Ltd. | 133,005 | 378,000 | 0.26% | ||
| 31 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 132,288 | 376,000 | 0.25% | ||
| 32 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 132,000 | 375,000 | 0.25% | ||
| 33 | CREDIT SUISSE AG/ | 129,571 | 367,000 | 0.25% | ||
| 34 | TEACHERS ADVISORS, LLC | 117,398 | 333,000 | 0.23% | ||
| 35 | CORRADO ADVISORS, LLC | 115,700 | 329,000 | 0.22% | ||
| 36 | FEDERATED HERMES, INC. | 104,574 | 297,000 | 0.20% | ||
| 37 | RHUMBLINE ADVISERS | 100,454 | 285,000 | 0.19% | ||
| 38 | Amici Capital, LLC | 100,000 | 284,000 | 0.19% | ||
| 39 | AQR CAPITAL MANAGEMENT LLC | 97,873 | 278,000 | 0.19% | ||
| 40 | Swiss National Bank | 96,300 | 273,000 | 0.18% | ||
| 41 | Janney Montgomery Scott LLC | 25,935 | 268,000 | 0.18% | ||
| 42 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 87,240 | 248,000 | 0.17% | ||
| 43 | VIRTUS ETF ADVISERS LLC | 84,907 | 241,000 | 0.16% | ||
| 44 | UBS Group AG | 84,170 | 239,000 | 0.16% | ||
| 45 | NEW YORK STATE COMMON RETIREMENT FUND | 69,300 | 197,000 | 0.13% | ||
| 46 | Quantitative Systematic Strategies LLC | 63,918 | 186,000 | 0.13% | ||
| 47 | ProShare Advisors LLC | 63,843 | 181,000 | 0.12% | ||
| 48 | METROPOLITAN LIFE INSURANCE CO/NY | 63,516 | 180,000 | 0.12% | ||
| 49 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 63,200 | 179,000 | 0.12% | Call | |
| 50 | CORNERSTONE CAPITAL MANAGEMENT HOLDINGS LLC. | 55,500 | 158,000 | 0.11% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
