| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 10,713,686 | 130,278,000 | 17.45% | ||
| 2 | FMR LLC | 10,424,425 | 126,761,000 | 16.98% | ||
| 3 | WELLINGTON MANAGEMENT GROUP LLP | 7,389,273 | 89,854,000 | 12.03% | ||
| 4 | RA CAPITAL MANAGEMENT, L.P. | 7,050,356 | 85,732,000 | 11.48% | ||
| 5 | BlackRock Fund Advisors | 2,804,541 | 34,103,000 | 4.57% | ||
| 6 | STATE STREET CORP | 2,790,435 | 33,933,000 | 4.54% | ||
| 7 | VANGUARD GROUP INC | 2,284,328 | 27,778,000 | 3.72% | ||
| 8 | RTW INVESTMENTS, LP | 2,261,361 | 27,498,000 | 3.68% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 1,912,804 | 23,260,000 | 3.12% | ||
| 10 | VHCP Management, LLC | 1,744,356 | 21,211,000 | 2.84% | ||
| 11 | D. E. Shaw & Co., Inc. | 1,670,539 | 20,313,000 | 2.72% | ||
| 12 | QVT Financial LP | 1,246,282 | 15,155,000 | 2.03% | ||
| 13 | NORTHERN TRUST CORP | 839,066 | 10,202,000 | 1.37% | ||
| 14 | Cormorant Asset Management, LP | 800,000 | 9,728,000 | 1.30% | ||
| 15 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 478,383 | 5,818,000 | 0.78% | ||
| 16 | AQR CAPITAL MANAGEMENT LLC | 475,435 | 5,782,000 | 0.77% | ||
| 17 | GEODE CAPITAL MANAGEMENT, LLC | 419,905 | 5,106,000 | 0.68% | ||
| 18 | Bank of New York Mellon Corp | 366,332 | 4,454,000 | 0.60% | ||
| 19 | TIAA CREF INVESTMENT MANAGEMENT LLC | 352,554 | 4,287,000 | 0.57% | ||
| 20 | BLACKROCK ADVISORS LLC | 343,106 | 4,172,000 | 0.56% | ||
| 21 | AXA S.A. | 325,587 | 3,959,000 | 0.53% | ||
| 22 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 303,000 | 3,684,000 | 0.49% | Put | |
| 23 | GUGGENHEIM CAPITAL LLC | 264,963 | 3,222,000 | 0.43% | ||
| 24 | GOLDMAN SACHS GROUP INC | 258,475 | 3,143,000 | 0.42% | ||
| 25 | Candriam S.C.A. | 253,000 | 3,076,000 | 0.41% | ||
| 26 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 251,700 | 3,061,000 | 0.41% | Call | |
| 27 | BlackRock Investment Management, LLC | 224,364 | 2,728,000 | 0.37% | ||
| 28 | Connor, Clark & Lunn Investment Management Ltd. | 213,098 | 2,591,000 | 0.35% | ||
| 29 | DAFNA Capital Management LLC | 166,656 | 2,027,000 | 0.27% | ||
| 30 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 160,500 | 1,775,000 | 0.24% | ||
| 31 | BlackRock Group LTD | 143,195 | 1,741,000 | 0.23% | ||
| 32 | MACQUARIE GROUP LTD | 142,167 | 1,729,000 | 0.23% | ||
| 33 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 129,787 | 1,578,000 | 0.21% | ||
| 34 | ALLIANCEBERNSTEIN L.P. | 107,800 | 1,311,000 | 0.18% | ||
| 35 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 106,806 | 1,299,000 | 0.17% | ||
| 36 | SIT INVESTMENT ASSOCIATES INC | 104,525 | 1,271,000 | 0.17% | ||
| 37 | BARCLAYS PLC | 100,500 | 1,206,000 | 0.16% | Call | |
| 38 | TEACHERS ADVISORS, LLC | 98,183 | 1,194,000 | 0.16% | ||
| 39 | MILLENNIUM MANAGEMENT LLC | 90,268 | 1,098,000 | 0.15% | ||
| 40 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 84,226 | 1,024,000 | 0.14% | ||
| 41 | Iguana Healthcare Management, LLC | 75,000 | 912,000 | 0.12% | ||
| 42 | UBS Group AG | 70,574 | 858,000 | 0.11% | ||
| 43 | NATIONAL PLANNING CORP | 70,050 | 845,504 | 0.11% | ||
| 44 | RHUMBLINE ADVISERS | 69,084 | 840,000 | 0.11% | ||
| 45 | CREDIT SUISSE AG/ | 67,353 | 819,000 | 0.11% | ||
| 46 | Swiss National Bank | 66,300 | 806,000 | 0.11% | ||
| 47 | Nationwide Fund Advisors | 65,677 | 799,000 | 0.11% | ||
| 48 | MASON STREET ADVISORS, LLC | 64,300 | 782,000 | 0.10% | ||
| 49 | BlackRock Finance, Inc. | 63,617 | 774,000 | 0.10% | ||
| 50 | ProShare Advisors LLC | 62,577 | 761,000 | 0.10% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
