| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 14,110,179 | 160,856,000 | 21.45% | ||
| 2 | FMR LLC | 7,750,127 | 88,351,000 | 11.78% | ||
| 3 | WELLINGTON MANAGEMENT GROUP LLP | 7,501,936 | 85,523,000 | 11.41% | ||
| 4 | STATE STREET CORP | 3,152,313 | 35,938,000 | 4.79% | ||
| 5 | BlackRock Fund Advisors | 2,911,728 | 33,194,000 | 4.43% | ||
| 6 | VANGUARD GROUP INC | 2,544,586 | 29,008,000 | 3.87% | ||
| 7 | D. E. Shaw & Co., Inc. | 2,472,974 | 28,192,000 | 3.76% | ||
| 8 | RTW INVESTMENTS, LP | 2,228,206 | 25,402,000 | 3.39% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 1,692,262 | 19,292,000 | 2.57% | ||
| 10 | FRANKLIN RESOURCES INC | 1,412,817 | 16,106,000 | 2.15% | ||
| 11 | QVT Financial LP | 1,358,097 | 15,482,000 | 2.06% | ||
| 12 | JENNISON ASSOCIATES LLC | 1,324,549 | 15,100,000 | 2.01% | ||
| 13 | Invesco Ltd. | 1,198,914 | 13,668,000 | 1.82% | ||
| 14 | RA CAPITAL MANAGEMENT, L.P. | 1,196,603 | 13,641,000 | 1.82% | ||
| 15 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,107,089 | 12,621,000 | 1.68% | ||
| 16 | Cormorant Asset Management, LP | 1,080,000 | 12,312,000 | 1.64% | ||
| 17 | GOLDMAN SACHS GROUP INC | 1,029,770 | 11,739,000 | 1.57% | ||
| 18 | MILLENNIUM MANAGEMENT LLC | 954,888 | 10,886,000 | 1.45% | ||
| 19 | NORTHERN TRUST CORP | 899,132 | 10,251,000 | 1.37% | ||
| 20 | AXA S.A. | 648,218 | 7,390,000 | 0.99% | ||
| 21 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 490,747 | 5,594,000 | 0.75% | ||
| 22 | GEODE CAPITAL MANAGEMENT, LLC | 437,068 | 4,982,000 | 0.66% | ||
| 23 | TEACHERS ADVISORS, LLC | 418,134 | 4,767,000 | 0.64% | ||
| 24 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 375,200 | 4,277,000 | 0.57% | Call | |
| 25 | TIAA CREF INVESTMENT MANAGEMENT LLC | 337,717 | 3,850,000 | 0.51% | ||
| 26 | Bank of New York Mellon Corp | 330,543 | 3,768,000 | 0.50% | ||
| 27 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 309,800 | 3,532,000 | 0.47% | Put | |
| 28 | ACUTA CAPITAL PARTNERS, LLC | 271,399 | 3,094,000 | 0.41% | ||
| 29 | DAFNA Capital Management LLC | 258,642 | 2,949,000 | 0.39% | SH | |
| 30 | BlackRock Investment Management, LLC | 257,680 | 2,938,000 | 0.39% | ||
| 31 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 245,760 | 2,802,000 | 0.37% | ||
| 32 | Connor, Clark & Lunn Investment Management Ltd. | 238,273 | 2,716,000 | 0.36% | ||
| 33 | OXFORD ASSET MANAGEMENT LLP | 233,481 | 2,662,000 | 0.36% | ||
| 34 | Ghost Tree Capital, LLC | 225,000 | 2,565,000 | 0.34% | ||
| 35 | DRIEHAUS CAPITAL MANAGEMENT LLC | 224,678 | 2,561,000 | 0.34% | ||
| 36 | PUTNAM INVESTMENTS LLC | 199,100 | 2,270,000 | 0.30% | ||
| 37 | LORD, ABBETT & CO. LLC | 180,413 | 2,057,000 | 0.27% | ||
| 38 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 152,240 | 1,736,000 | 0.23% | ||
| 39 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 144,500 | 1,647,000 | 0.22% | ||
| 40 | CITADEL ADVISORS LLC | 143,954 | 1,641,000 | 0.22% | ||
| 41 | SIT INVESTMENT ASSOCIATES INC | 141,525 | 1,613,000 | 0.22% | ||
| 42 | MACQUARIE GROUP LTD | 137,442 | 1,567,000 | 0.21% | ||
| 43 | DEUTSCHE BANK AG\ | 135,354 | 1,540,000 | 0.21% | ||
| 44 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 132,050 | 1,505,000 | 0.20% | ||
| 45 | Nationwide Fund Advisors | 130,253 | 1,485,000 | 0.20% | ||
| 46 | EMORY UNIVERSITY | 129,415 | 1,475,000 | 0.20% | ||
| 47 | PERCEPTIVE ADVISORS LLC | 123,745 | 1,411,000 | 0.19% | ||
| 48 | ALLIANCEBERNSTEIN L.P. | 118,420 | 1,350,000 | 0.18% | ||
| 49 | CORRADO ADVISORS, LLC | 114,910 | 1,310,000 | 0.17% | ||
| 50 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 113,606 | 1,295,000 | 0.17% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
