| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 11,716,784 | 98,421,000 | 20.34% | ||
| 2 | BlackRock Finance, Inc. | 6,014,277 | 50,520,000 | 10.44% | ||
| 3 | VANGUARD GROUP INC | 5,011,763 | 42,098,000 | 8.70% | ||
| 4 | RA CAPITAL MANAGEMENT, L.P. | 3,489,795 | 29,314,000 | 6.06% | ||
| 5 | RTW INVESTMENTS, LP | 3,458,120 | 29,048,000 | 6.00% | ||
| 6 | D. E. Shaw & Co., Inc. | 3,153,628 | 26,491,000 | 5.47% | ||
| 7 | DEERFIELD MANAGEMENT COMPANY, L.P. | 3,085,236 | 25,916,000 | 5.36% | ||
| 8 | MILLENNIUM MANAGEMENT LLC | 2,838,649 | 23,845,000 | 4.93% | ||
| 9 | STATE STREET CORP | 2,272,104 | 19,083,000 | 3.94% | ||
| 10 | JENNISON ASSOCIATES LLC | 1,844,636 | 15,495,000 | 3.20% | ||
| 11 | FMR LLC | 1,456,885 | 12,238,000 | 2.53% | ||
| 12 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 1,078,345 | 9,058,000 | 1.87% | ||
| 13 | Invesco Ltd. | 956,098 | 8,031,000 | 1.66% | ||
| 14 | NORTHERN TRUST CORP | 908,763 | 7,633,000 | 1.58% | ||
| 15 | GOLDMAN SACHS GROUP INC | 787,689 | 6,616,000 | 1.37% | ||
| 16 | GEODE CAPITAL MANAGEMENT, LLC | 773,115 | 6,493,000 | 1.34% | ||
| 17 | DAFNA Capital Management LLC | 541,128 | 4,545,000 | 0.94% | ||
| 18 | Artal Group S.A. | 500,000 | 4,200,000 | 0.87% | ||
| 19 | MORGAN STANLEY | 474,185 | 3,983,000 | 0.82% | ||
| 20 | TWO SIGMA INVESTMENTS, LP | 457,647 | 3,844,000 | 0.79% | ||
| 21 | EMORY UNIVERSITY | 375,348 | 3,153,000 | 0.65% | ||
| 22 | Bank of New York Mellon Corp | 361,289 | 3,035,000 | 0.63% | ||
| 23 | TIAA CREF INVESTMENT MANAGEMENT LLC | 352,100 | 2,958,000 | 0.61% | ||
| 24 | PAULSON & CO. INC. | 350,000 | 2,940,000 | 0.61% | Call | |
| 25 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 333,373 | 2,801,000 | 0.58% | ||
| 26 | UNIVERSITY OF NOTRE DAME DU LAC | 322,164 | 2,706,000 | 0.56% | ||
| 27 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 313,800 | 2,636,000 | 0.54% | Call | |
| 28 | FEDERATED HERMES, INC. | 252,060 | 2,117,000 | 0.44% | ||
| 29 | JPMORGAN CHASE & CO | 250,855 | 2,107,000 | 0.44% | ||
| 30 | DEUTSCHE BANK AG\ | 223,678 | 1,878,000 | 0.39% | ||
| 31 | RENAISSANCE TECHNOLOGIES LLC | 219,203 | 1,841,000 | 0.38% | ||
| 32 | WELLINGTON MANAGEMENT GROUP LLP | 202,317 | 1,700,000 | 0.35% | ||
| 33 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 201,400 | 1,692,000 | 0.35% | Put | |
| 34 | MILLENNIUM MANAGEMENT LLC | 200,000 | 1,680,000 | 0.35% | Call | |
| 35 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 157,383 | 1,322,000 | 0.27% | ||
| 36 | ROYCE & ASSOCIATES LP | 144,000 | 1,210,000 | 0.25% | ||
| 37 | CITADEL ADVISORS LLC | 134,525 | 1,130,000 | 0.23% | ||
| 38 | Gotham Asset Management, LLC | 126,553 | 1,063,000 | 0.22% | ||
| 39 | TEACHERS ADVISORS, LLC | 125,947 | 1,058,000 | 0.22% | ||
| 40 | Allianz Asset Management GmbH | 119,978 | 1,008,000 | 0.21% | ||
| 41 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 118,300 | 994,000 | 0.21% | ||
| 42 | CREDIT SUISSE AG/ | 110,837 | 931,000 | 0.19% | ||
| 43 | Informed Momentum Co LLC | 109,625 | 921,000 | 0.19% | ||
| 44 | ALLIANCEBERNSTEIN L.P. | 107,620 | 904,000 | 0.19% | ||
| 45 | GROUP ONE TRADING LLC | 95,908 | 806,000 | 0.17% | ||
| 46 | RHUMBLINE ADVISERS | 87,468 | 735,000 | 0.15% | ||
| 47 | WELLS FARGO & COMPANY/MN | 80,103 | 673,000 | 0.14% | ||
| 48 | NEW YORK STATE COMMON RETIREMENT FUND | 69,301 | 582,000 | 0.12% | ||
| 49 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 68,097 | 572,000 | 0.12% | ||
| 50 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 60,589 | 509,000 | 0.11% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
