| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | WASATCH ADVISORS LP | 3,333,214 | 78,364,000 | 14.85% | ||
| 2 | Aisling Capital LLC | 3,293,060 | 77,420,000 | 14.67% | ||
| 3 | ONTARIO TEACHERS PENSION PLAN BOARD | 1,209,506 | 28,435,000 | 5.39% | ||
| 4 | BlackRock Fund Advisors | 1,109,434 | 26,083,000 | 4.94% | ||
| 5 | FMR LLC | 789,852 | 18,569,000 | 3.52% | ||
| 6 | BB BIOTECH AG | 775,000 | 18,220,000 | 3.45% | ||
| 7 | VANGUARD GROUP INC | 753,758 | 17,721,000 | 3.36% | ||
| 8 | GOLDMAN SACHS GROUP INC | 741,410 | 17,431,000 | 3.30% | ||
| 9 | Abingworth LLP | 714,285 | 16,779,000 | 3.18% | ||
| 10 | Opaleye Management Inc. | 504,800 | 11,868,000 | 2.25% | ||
| 11 | TimesSquare Capital Management, LLC | 486,020 | 11,426,000 | 2.16% | ||
| 12 | Devon Park Associates, LLC | 390,144 | 9,172,000 | 1.74% | ||
| 13 | BlackRock Institutional Trust Company, N.A. | 367,658 | 8,644,000 | 1.64% | ||
| 14 | AXA S.A. | 331,121 | 7,785,000 | 1.48% | ||
| 15 | COLUMBIA PARTNERS L.L.C. INVESTMENT MANAGEMENT | 320,530 | 7,535,000 | 1.43% | ||
| 16 | WILLIAM HARRIS INVESTORS INC | 307,698 | 7,233,000 | 1.37% | ||
| 17 | STATE STREET CORP | 307,392 | 7,228,000 | 1.37% | ||
| 18 | PUTNAM INVESTMENTS LLC | 300,500 | 7,065,000 | 1.34% | ||
| 19 | Broadfin Capital, LLC | 284,625 | 6,692,000 | 1.27% | ||
| 20 | VOYA INVESTMENT MANAGEMENT LLC | 281,900 | 6,628,000 | 1.26% | ||
| 21 | NORTHERN TRUST CORP | 260,384 | 6,122,000 | 1.16% | ||
| 22 | PERCEPTIVE ADVISORS LLC | 247,500 | 5,819,000 | 1.10% | ||
| 23 | C WorldWide Group Holding A/S | 236,584 | 5,562,000 | 1.05% | ||
| 24 | WELLS FARGO & COMPANY/MN | 232,610 | 5,469,000 | 1.04% | ||
| 25 | Informed Momentum Co LLC | 231,286 | 5,438,000 | 1.03% | ||
| 26 | Grandeur Peak Global Advisors, LLC | 222,850 | 5,239,000 | 0.99% | ||
| 27 | HIGHLAND CAPITAL MANAGEMENT LP | 191,145 | 4,494,000 | 0.85% | ||
| 28 | MILLENNIUM MANAGEMENT LLC | 188,542 | 4,433,000 | 0.84% | ||
| 29 | Bank of New York Mellon Corp | 176,172 | 4,142,000 | 0.78% | ||
| 30 | ACUTA CAPITAL PARTNERS, LLC | 164,800 | 3,874,000 | 0.73% | Call | |
| 31 | DRIEHAUS CAPITAL MANAGEMENT LLC | 162,439 | 3,819,000 | 0.72% | ||
| 32 | GEODE CAPITAL MANAGEMENT, LLC | 160,276 | 3,768,000 | 0.71% | ||
| 33 | A.R.T. Advisors, LLC | 160,209 | 3,766,000 | 0.71% | ||
| 34 | South Dakota Investment Council | 154,510 | 3,633,000 | 0.69% | ||
| 35 | EVENTIDE ASSET MANAGEMENT, LLC | 153,800 | 3,616,000 | 0.69% | ||
| 36 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 150,800 | 3,545,000 | 0.67% | Call | |
| 37 | Fiduciary Trust Co International of Pennsylvania | 137,067 | 3,222,000 | 0.61% | ||
| 38 | RUSSELL FRANK CO/ | 131,027 | 3,076,000 | 0.58% | ||
| 39 | GENERAL AMERICAN INVESTORS CO INC | 120,000 | 2,821,000 | 0.53% | ||
| 40 | SPHERA FUNDS MANAGEMENT LTD. | 100,000 | 2,351,000 | 0.45% | ||
| 41 | TWO SIGMA INVESTMENTS, LP | 98,377 | 2,313,000 | 0.44% | ||
| 42 | PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 98,381 | 2,313,000 | 0.44% | ||
| 43 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 97,500 | 2,292,000 | 0.43% | ||
| 44 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 94,700 | 2,226,000 | 0.42% | Put | |
| 45 | CITADEL ADVISORS LLC | 87,860 | 2,066,000 | 0.39% | ||
| 46 | Weiss Multi-Strategy Advisers LLC | 80,000 | 1,881,000 | 0.36% | ||
| 47 | TIAA CREF INVESTMENT MANAGEMENT LLC | 79,837 | 1,877,000 | 0.36% | ||
| 48 | Allianz Asset Management GmbH | 72,051 | 1,694,000 | 0.32% | ||
| 49 | AMERIPRISE FINANCIAL INC | 71,073 | 1,671,000 | 0.32% | ||
| 50 | BlackRock Investment Management, LLC | 70,193 | 1,650,000 | 0.31% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
