| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 7,798,670 | 188,728,000 | 18.55% | ||
| 2 | VANGUARD GROUP INC | 3,369,816 | 81,550,000 | 8.02% | ||
| 3 | Palo Alto Investors LP | 2,844,483 | 68,836,000 | 6.77% | ||
| 4 | BB BIOTECH AG | 2,041,900 | 49,414,000 | 4.86% | ||
| 5 | TimesSquare Capital Management, LLC | 1,931,360 | 46,739,000 | 4.59% | ||
| 6 | WASATCH ADVISORS LP | 1,924,338 | 46,569,000 | 4.58% | ||
| 7 | BlackRock Fund Advisors | 1,826,182 | 44,194,000 | 4.34% | ||
| 8 | Aisling Capital LLC | 1,193,060 | 28,872,000 | 2.84% | ||
| 9 | STATE STREET CORP | 1,147,848 | 27,776,000 | 2.73% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 1,097,981 | 26,571,000 | 2.61% | ||
| 11 | LEVIN CAPITAL STRATEGIES, L.P. | 985,090 | 23,839,000 | 2.34% | ||
| 12 | GOLDMAN SACHS GROUP INC | 902,961 | 21,852,000 | 2.15% | ||
| 13 | C WorldWide Group Holding A/S | 896,800 | 21,703,000 | 2.13% | ||
| 14 | ONTARIO TEACHERS PENSION PLAN BOARD | 854,564 | 20,680,000 | 2.03% | ||
| 15 | VOYA INVESTMENT MANAGEMENT LLC | 662,365 | 16,030,000 | 1.58% | ||
| 16 | NORTHERN TRUST CORP | 518,685 | 12,552,000 | 1.23% | ||
| 17 | GENERAL AMERICAN INVESTORS CO INC | 514,409 | 12,449,000 | 1.22% | ||
| 18 | HIGHLAND CAPITAL MANAGEMENT LP | 433,232 | 10,484,000 | 1.03% | ||
| 19 | Invesco Ltd. | 422,235 | 10,218,000 | 1.00% | ||
| 20 | PEREGRINE CAPITAL MANAGEMENT INC /MN/ | 408,251 | 9,880,000 | 0.97% | ||
| 21 | JPMORGAN CHASE & CO | 398,622 | 9,647,000 | 0.95% | ||
| 22 | Abingworth LLP | 383,935 | 9,287,000 | 0.91% | ||
| 23 | AXA S.A. | 383,533 | 9,281,000 | 0.91% | ||
| 24 | GEODE CAPITAL MANAGEMENT, LLC | 339,699 | 8,220,000 | 0.81% | ||
| 25 | D. E. Shaw & Co., Inc. | 274,709 | 6,648,000 | 0.65% | ||
| 26 | COLUMBIA PARTNERS L.L.C. INVESTMENT MANAGEMENT | 272,111 | 6,585,000 | 0.65% | ||
| 27 | Bank of New York Mellon Corp | 271,407 | 6,569,000 | 0.65% | ||
| 28 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 253,600 | 6,137,000 | 0.60% | Call | |
| 29 | NORGES BANK | 265,197 | 6,130,000 | 0.60% | ||
| 30 | GABELLI FUNDS LLC | 251,400 | 6,084,000 | 0.60% | ||
| 31 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 239,300 | 5,791,000 | 0.57% | Put | |
| 32 | HANDELSBANKEN FONDER AB | 230,000 | 5,566,000 | 0.55% | ||
| 33 | Portolan Capital Management, LLC | 226,893 | 5,491,000 | 0.54% | ||
| 34 | South Dakota Investment Council | 226,795 | 5,488,000 | 0.54% | ||
| 35 | ACUTA CAPITAL PARTNERS, LLC | 210,000 | 5,082,000 | 0.50% | ||
| 36 | Artal Group S.A. | 200,000 | 4,840,000 | 0.48% | ||
| 37 | EVENTIDE ASSET MANAGEMENT, LLC | 184,900 | 4,475,000 | 0.44% | ||
| 38 | Knoll Capital Management, LLC | 180,800 | 4,318,000 | 0.42% | ||
| 39 | EMERALD ACQUISITION LTD. | 175,951 | 4,258,000 | 0.42% | ||
| 40 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 175,648 | 4,251,000 | 0.42% | ||
| 41 | PERCEPTIVE ADVISORS LLC | 175,503 | 4,247,000 | 0.42% | ||
| 42 | TIAA CREF INVESTMENT MANAGEMENT LLC | 171,856 | 4,159,000 | 0.41% | ||
| 43 | BlackRock Investment Management, LLC | 167,412 | 4,051,000 | 0.40% | ||
| 44 | RICE HALL JAMES & ASSOCIATES, LLC | 163,182 | 3,949,000 | 0.39% | ||
| 45 | Rhenman & Partners Asset Management AB | 161,000 | 3,896,200 | 0.38% | ||
| 46 | MORGAN STANLEY | 157,275 | 3,806,000 | 0.37% | ||
| 47 | CHARTWELL INVESTMENT PARTNERS, LLC | 153,475 | 3,714,000 | 0.37% | ||
| 48 | NEW YORK STATE COMMON RETIREMENT FUND | 144,780 | 3,504,000 | 0.34% | ||
| 49 | HARVEY CAPITAL MANAGEMENT INC | 133,825 | 3,238,000 | 0.32% | ||
| 50 | WILLIAM HARRIS INVESTORS INC | 131,045 | 3,171,000 | 0.31% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
