| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 7,230,082 | 119,224,000 | 17.89% | ||
| 2 | VANGUARD GROUP INC | 2,830,273 | 46,671,000 | 7.00% | ||
| 3 | Palo Alto Investors LP | 2,787,542 | 45,967,000 | 6.90% | ||
| 4 | WASATCH ADVISORS LP | 2,426,832 | 40,018,000 | 6.01% | ||
| 5 | TimesSquare Capital Management, LLC | 2,050,860 | 33,819,000 | 5.08% | ||
| 6 | BB BIOTECH AG | 2,041,900 | 33,671,000 | 5.05% | ||
| 7 | BlackRock Fund Advisors | 1,600,500 | 26,392,000 | 3.96% | ||
| 8 | LEVIN CAPITAL STRATEGIES, L.P. | 1,429,620 | 23,574,000 | 3.54% | ||
| 9 | Aisling Capital LLC | 1,193,060 | 19,674,000 | 2.95% | ||
| 10 | STATE STREET CORP | 1,032,492 | 17,027,000 | 2.56% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 1,003,737 | 16,552,000 | 2.48% | ||
| 12 | VOYA INVESTMENT MANAGEMENT LLC | 902,065 | 14,875,000 | 2.23% | ||
| 13 | GOLDMAN SACHS GROUP INC | 866,755 | 14,292,000 | 2.14% | ||
| 14 | ONTARIO TEACHERS PENSION PLAN BOARD | 854,564 | 14,092,000 | 2.11% | ||
| 15 | C WorldWide Group Holding A/S | 730,630 | 12,048,000 | 1.81% | ||
| 16 | GENERAL AMERICAN INVESTORS CO INC | 514,409 | 8,483,000 | 1.27% | ||
| 17 | WELLS FARGO & COMPANY/MN | 484,715 | 7,993,000 | 1.20% | ||
| 18 | EMERALD ACQUISITION LTD. | 476,036 | 7,850,000 | 1.18% | ||
| 19 | NORTHERN TRUST CORP | 469,725 | 7,745,000 | 1.16% | ||
| 20 | Invesco Ltd. | 422,216 | 6,962,000 | 1.04% | ||
| 21 | AXA S.A. | 416,319 | 6,865,000 | 1.03% | ||
| 22 | Abingworth LLP | 383,935 | 6,331,000 | 0.95% | ||
| 23 | GEODE CAPITAL MANAGEMENT, LLC | 310,304 | 5,116,000 | 0.77% | ||
| 24 | Portolan Capital Management, LLC | 295,575 | 4,874,000 | 0.73% | ||
| 25 | JPMORGAN CHASE & CO | 277,875 | 4,582,000 | 0.69% | ||
| 26 | GABELLI FUNDS LLC | 254,400 | 4,195,000 | 0.63% | ||
| 27 | COLUMBIA PARTNERS L.L.C. INVESTMENT MANAGEMENT | 252,998 | 4,171,000 | 0.63% | ||
| 28 | South Dakota Investment Council | 233,595 | 3,852,000 | 0.58% | ||
| 29 | Bank of New York Mellon Corp | 229,345 | 3,781,000 | 0.57% | ||
| 30 | ACUTA CAPITAL PARTNERS, LLC | 210,000 | 3,463,000 | 0.52% | ||
| 31 | RENAISSANCE TECHNOLOGIES LLC | 205,300 | 3,385,000 | 0.51% | ||
| 32 | NORGES BANK | 201,063 | 3,316,000 | 0.50% | ||
| 33 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 188,800 | 3,113,000 | 0.47% | Call | |
| 34 | EVENTIDE ASSET MANAGEMENT, LLC | 184,900 | 3,049,000 | 0.46% | ||
| 35 | Knoll Capital Management, LLC | 180,800 | 2,981,000 | 0.45% | ||
| 36 | Rhenman & Partners Asset Management AB | 171,000 | 2,820,000 | 0.42% | ||
| 37 | PERCEPTIVE ADVISORS LLC | 170,000 | 2,803,000 | 0.42% | ||
| 38 | TIAA CREF INVESTMENT MANAGEMENT LLC | 165,246 | 2,725,000 | 0.41% | ||
| 39 | DEUTSCHE BANK AG\ | 156,612 | 2,582,000 | 0.39% | ||
| 40 | BlackRock Investment Management, LLC | 153,781 | 2,536,000 | 0.38% | ||
| 41 | WILLIAM HARRIS INVESTORS INC | 151,045 | 2,491,000 | 0.37% | ||
| 42 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 148,128 | 2,443,000 | 0.37% | ||
| 43 | RICE HALL JAMES & ASSOCIATES, LLC | 145,519 | 2,400,000 | 0.36% | ||
| 44 | NEW YORK STATE COMMON RETIREMENT FUND | 134,572 | 2,219,000 | 0.33% | ||
| 45 | STONERIDGE INVESTMENT PARTNERS LLC | 132,387 | 2,183,000 | 0.33% | ||
| 46 | PRICE T ROWE ASSOCIATES INC /MD/ | 128,686 | 2,122,000 | 0.32% | ||
| 47 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 120,700 | 1,990,000 | 0.30% | ||
| 48 | SEI INVESTMENTS CO | 119,912 | 1,977,000 | 0.30% | ||
| 49 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 118,900 | 1,961,000 | 0.29% | Put | |
| 50 | D. E. Shaw & Co., Inc. | 110,244 | 1,818,000 | 0.27% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
