| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | VANGUARD GROUP INC | 2,203,806 | 61,354,000 | 7.20% | ||
| 2 | Aisling Capital LLC | 2,193,060 | 61,055,000 | 7.17% | ||
| 3 | BB BIOTECH AG | 1,891,900 | 52,670,000 | 6.18% | ||
| 4 | WASATCH ADVISORS LP | 1,799,357 | 50,094,000 | 5.88% | ||
| 5 | FMR LLC | 1,402,355 | 39,042,000 | 4.58% | ||
| 6 | BlackRock Fund Advisors | 1,401,727 | 39,024,000 | 4.58% | ||
| 7 | STATE STREET CORP | 1,267,079 | 35,276,000 | 4.14% | ||
| 8 | TimesSquare Capital Management, LLC | 1,073,055 | 29,874,000 | 3.51% | ||
| 9 | ONTARIO TEACHERS PENSION PLAN BOARD | 836,382 | 23,285,000 | 2.73% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 800,664 | 22,290,000 | 2.62% | ||
| 11 | C WorldWide Group Holding A/S | 766,930 | 21,351,000 | 2.51% | ||
| 12 | GOLDMAN SACHS GROUP INC | 644,120 | 17,933,000 | 2.11% | ||
| 13 | MILLENNIUM MANAGEMENT LLC | 632,252 | 17,602,000 | 2.07% | ||
| 14 | PERCEPTIVE ADVISORS LLC | 582,500 | 16,217,000 | 1.90% | ||
| 15 | BLACKROCK ADVISORS LLC | 522,211 | 14,539,000 | 1.71% | ||
| 16 | HIGHLAND CAPITAL MANAGEMENT LP | 522,060 | 14,535,000 | 1.71% | ||
| 17 | GOLDMAN SACHS GROUP INC | 487,900 | 13,583,000 | 1.59% | Call | |
| 18 | COLUMBUS CIRCLE INVESTORS | 456,057 | 12,697,000 | 1.49% | ||
| 19 | Invesco Ltd. | 421,817 | 11,744,000 | 1.38% | ||
| 20 | VOYA INVESTMENT MANAGEMENT LLC | 400,582 | 11,152,000 | 1.31% | ||
| 21 | LEVIN CAPITAL STRATEGIES, L.P. | 397,770 | 11,074,000 | 1.30% | ||
| 22 | Abingworth LLP | 383,935 | 10,685,000 | 1.25% | ||
| 23 | NORTHERN TRUST CORP | 361,077 | 10,052,000 | 1.18% | ||
| 24 | Opaleye Management Inc. | 360,000 | 10,022,000 | 1.18% | ||
| 25 | HealthCor Management, L.P. | 350,000 | 9,744,000 | 1.14% | ||
| 26 | AXA S.A. | 305,197 | 8,497,000 | 1.00% | ||
| 27 | PUTNAM INVESTMENTS LLC | 301,100 | 8,383,000 | 0.98% | ||
| 28 | Rhenman & Partners Asset Management AB | 298,000 | 8,296,000 | 0.97% | ||
| 29 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 274,200 | 7,634,000 | 0.90% | Put | |
| 30 | JPMORGAN CHASE & CO | 273,587 | 7,617,000 | 0.89% | ||
| 31 | WELLS FARGO & COMPANY/MN | 268,909 | 7,486,000 | 0.88% | ||
| 32 | CAPITAL FUND MANAGEMENT S.A. | 237,821 | 6,621,000 | 0.78% | ||
| 33 | HARVEY CAPITAL MANAGEMENT INC | 224,300 | 6,244,000 | 0.73% | ||
| 34 | GEODE CAPITAL MANAGEMENT, LLC | 223,799 | 6,230,000 | 0.73% | ||
| 35 | WILLIAM HARRIS INVESTORS INC | 211,178 | 5,879,000 | 0.69% | ||
| 36 | NORGES BANK | 207,421 | 5,775,000 | 0.68% | ||
| 37 | CI Global Investments Inc. | 200,000 | 5,568,000 | 0.65% | ||
| 38 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 183,119 | 5,098,000 | 0.60% | ||
| 39 | GENERAL AMERICAN INVESTORS CO INC | 170,000 | 4,733,000 | 0.56% | ||
| 40 | GUGGENHEIM CAPITAL LLC | 164,617 | 4,583,000 | 0.54% | ||
| 41 | Bank of New York Mellon Corp | 156,804 | 4,365,000 | 0.51% | ||
| 42 | EVENTIDE ASSET MANAGEMENT, LLC | 156,800 | 4,365,000 | 0.51% | ||
| 43 | Candriam S.C.A. | 153,500 | 4,274,000 | 0.50% | ||
| 44 | NEXT CENTURY GROWTH INVESTORS LLC | 153,308 | 4,268,000 | 0.50% | ||
| 45 | Allianz Asset Management GmbH | 140,826 | 3,920,000 | 0.46% | ||
| 46 | BlackRock Investment Management, LLC | 139,183 | 3,875,000 | 0.45% | ||
| 47 | Jefferies Group LLC | 138,200 | 3,847,000 | 0.45% | Call | |
| 48 | Weiss Multi-Strategy Advisers LLC | 136,000 | 3,786,000 | 0.44% | ||
| 49 | Fiduciary Trust Co International of Pennsylvania | 135,567 | 3,774,000 | 0.44% | ||
| 50 | GOLDMAN SACHS GROUP INC | 131,200 | 3,653,000 | 0.43% | Put |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
