| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 7,225,459 | 126,590,000 | 18.61% | ||
| 2 | VANGUARD GROUP INC | 2,610,258 | 45,731,000 | 6.72% | ||
| 3 | LEVIN CAPITAL STRATEGIES, L.P. | 2,291,206 | 40,142,000 | 5.90% | ||
| 4 | WASATCH ADVISORS LP | 2,346,451 | 38,200,000 | 5.62% | ||
| 5 | BB BIOTECH AG | 2,041,900 | 35,774,000 | 5.26% | ||
| 6 | TimesSquare Capital Management, LLC | 2,036,360 | 35,677,000 | 5.25% | ||
| 7 | BlackRock Fund Advisors | 1,471,812 | 25,786,000 | 3.79% | ||
| 8 | Palo Alto Investors LP | 1,215,833 | 21,301,000 | 3.13% | ||
| 9 | STATE STREET CORP | 1,197,939 | 20,989,000 | 3.09% | ||
| 10 | Aisling Capital LLC | 1,193,060 | 20,902,000 | 3.07% | ||
| 11 | GOLDMAN SACHS GROUP INC | 1,121,767 | 19,654,000 | 2.89% | ||
| 12 | BlackRock Institutional Trust Company, N.A. | 958,391 | 16,791,000 | 2.47% | ||
| 13 | ONTARIO TEACHERS PENSION PLAN BOARD | 854,564 | 14,972,000 | 2.20% | ||
| 14 | C WorldWide Group Holding A/S | 764,930 | 13,402,000 | 1.97% | ||
| 15 | VOYA INVESTMENT MANAGEMENT LLC | 724,602 | 12,695,000 | 1.87% | ||
| 16 | GENERAL AMERICAN INVESTORS CO INC | 514,409 | 9,012,000 | 1.33% | ||
| 17 | RUSSELL FRANK CO/ | 444,317 | 7,784,000 | 1.14% | ||
| 18 | AXA S.A. | 433,384 | 7,593,000 | 1.12% | ||
| 19 | Invesco Ltd. | 421,785 | 7,389,000 | 1.09% | ||
| 20 | NORTHERN TRUST CORP | 399,504 | 7,000,000 | 1.03% | ||
| 21 | Abingworth LLP | 383,935 | 6,723,000 | 0.99% | ||
| 22 | WELLS FARGO & COMPANY/MN | 369,236 | 6,469,000 | 0.95% | ||
| 23 | TREDJE AP-FONDEN | 400,000 | 6,088,000 | 0.90% | ||
| 24 | GEODE CAPITAL MANAGEMENT, LLC | 284,405 | 4,982,000 | 0.73% | ||
| 25 | LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 275,550 | 4,828,000 | 0.71% | ||
| 26 | JPMORGAN CHASE & CO | 273,321 | 4,789,000 | 0.70% | ||
| 27 | South Dakota Investment Council | 233,595 | 4,093,000 | 0.60% | ||
| 28 | ACUTA CAPITAL PARTNERS, LLC | 210,000 | 3,679,000 | 0.54% | ||
| 29 | NORGES BANK | 201,063 | 3,523,000 | 0.52% | ||
| 30 | Portolan Capital Management, LLC | 195,183 | 3,420,000 | 0.50% | ||
| 31 | Bank of New York Mellon Corp | 190,238 | 3,333,000 | 0.49% | ||
| 32 | EVENTIDE ASSET MANAGEMENT, LLC | 184,900 | 3,239,000 | 0.48% | ||
| 33 | SOROS FUND MANAGEMENT LLC | 181,825 | 3,186,000 | 0.47% | ||
| 34 | Knoll Capital Management, LLC | 180,800 | 3,168,000 | 0.47% | ||
| 35 | Rhenman & Partners Asset Management AB | 171,000 | 2,996,000 | 0.44% | ||
| 36 | WILLIAM HARRIS INVESTORS INC | 151,045 | 2,646,000 | 0.39% | ||
| 37 | PERCEPTIVE ADVISORS LLC | 150,000 | 2,628,000 | 0.39% | ||
| 38 | STONERIDGE INVESTMENT PARTNERS LLC | 148,689 | 2,605,000 | 0.38% | ||
| 39 | TIAA CREF INVESTMENT MANAGEMENT LLC | 147,363 | 2,582,000 | 0.38% | ||
| 40 | GABELLI FUNDS LLC | 140,000 | 2,453,000 | 0.36% | ||
| 41 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 138,220 | 2,422,000 | 0.36% | ||
| 42 | PRICE T ROWE ASSOCIATES INC /MD/ | 128,686 | 2,255,000 | 0.33% | ||
| 43 | NEW YORK STATE COMMON RETIREMENT FUND | 127,468 | 2,233,000 | 0.33% | ||
| 44 | BlackRock Investment Management, LLC | 122,644 | 2,149,000 | 0.32% | ||
| 45 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 120,700 | 2,115,000 | 0.31% | ||
| 46 | SEI INVESTMENTS CO | 119,824 | 2,099,000 | 0.31% | ||
| 47 | COLUMBIA PARTNERS L.L.C. INVESTMENT MANAGEMENT | 119,785 | 2,098,000 | 0.31% | ||
| 48 | Candriam S.C.A. | 115,000 | 2,004,000 | 0.29% | ||
| 49 | UBS Group AG | 110,784 | 1,941,000 | 0.29% | ||
| 50 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 110,557 | 1,937,000 | 0.28% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
