| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Aisling Capital LLC | 3,293,060 | 112,985,000 | 12.26% | ||
| 2 | WASATCH ADVISORS LP | 2,663,276 | 91,377,000 | 9.92% | ||
| 3 | STATE STREET CORP | 1,425,591 | 48,914,000 | 5.31% | ||
| 4 | BlackRock Fund Advisors | 1,383,375 | 47,464,000 | 5.15% | ||
| 5 | BB BIOTECH AG | 1,223,000 | 41,961,000 | 4.55% | ||
| 6 | FMR LLC | 1,049,576 | 36,010,000 | 3.91% | ||
| 7 | VANGUARD GROUP INC | 1,042,189 | 35,758,000 | 3.88% | ||
| 8 | ONTARIO TEACHERS PENSION PLAN BOARD | 1,016,382 | 34,872,000 | 3.78% | ||
| 9 | TimesSquare Capital Management, LLC | 999,800 | 34,303,000 | 3.72% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 748,274 | 25,673,000 | 2.79% | ||
| 11 | GOLDMAN SACHS GROUP INC | 629,195 | 21,588,000 | 2.34% | ||
| 12 | PERCEPTIVE ADVISORS LLC | 572,500 | 19,642,000 | 2.13% | ||
| 13 | C WorldWide Group Holding A/S | 570,000 | 19,557,000 | 2.12% | ||
| 14 | Abingworth LLP | 524,285 | 17,988,000 | 1.95% | ||
| 15 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 521,289 | 17,885,000 | 1.94% | ||
| 16 | Opaleye Management Inc. | 500,000 | 17,155,000 | 1.86% | ||
| 17 | NORTHERN TRUST CORP | 324,513 | 11,134,000 | 1.21% | ||
| 18 | COLUMBIA PARTNERS L.L.C. INVESTMENT MANAGEMENT | 323,805 | 11,109,000 | 1.21% | ||
| 19 | Invesco Ltd. | 316,073 | 10,845,000 | 1.18% | ||
| 20 | AXA S.A. | 312,837 | 10,733,000 | 1.16% | ||
| 21 | PUTNAM INVESTMENTS LLC | 300,500 | 10,310,000 | 1.12% | ||
| 22 | VOYA INVESTMENT MANAGEMENT LLC | 296,230 | 10,164,000 | 1.10% | ||
| 23 | LORD, ABBETT & CO. LLC | 253,527 | 8,698,000 | 0.94% | ||
| 24 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 236,273 | 8,107,000 | 0.88% | ||
| 25 | GEODE CAPITAL MANAGEMENT, LLC | 233,198 | 8,001,000 | 0.87% | ||
| 26 | WILLIAM HARRIS INVESTORS INC | 228,928 | 7,855,000 | 0.85% | ||
| 27 | CITADEL ADVISORS LLC | 223,607 | 7,672,000 | 0.83% | ||
| 28 | HARVEY CAPITAL MANAGEMENT INC | 215,150 | 7,381,000 | 0.80% | ||
| 29 | SABBY MANAGEMENT, LLC | 200,400 | 6,876,000 | 0.75% | ||
| 30 | DRIEHAUS CAPITAL MANAGEMENT LLC | 194,234 | 6,664,000 | 0.72% | ||
| 31 | WELLS FARGO & COMPANY/MN | 191,550 | 6,573,000 | 0.71% | ||
| 32 | Bank of New York Mellon Corp | 189,502 | 6,502,000 | 0.71% | ||
| 33 | Rhenman & Partners Asset Management AB | 185,300 | 6,358,000 | 0.69% | ||
| 34 | ACUTA CAPITAL PARTNERS, LLC | 170,400 | 5,846,000 | 0.63% | ||
| 35 | GENERAL AMERICAN INVESTORS CO INC | 170,000 | 5,833,000 | 0.63% | ||
| 36 | Candriam S.C.A. | 165,000 | 5,662,000 | 0.61% | ||
| 37 | A.R.T. Advisors, LLC | 157,103 | 5,390,000 | 0.58% | ||
| 38 | EVENTIDE ASSET MANAGEMENT, LLC | 153,800 | 5,277,000 | 0.57% | ||
| 39 | Fiduciary Trust Co International of Pennsylvania | 142,067 | 4,874,000 | 0.53% | ||
| 40 | HIGHLAND CAPITAL MANAGEMENT LP | 140,212 | 4,811,000 | 0.52% | ||
| 41 | TWO SIGMA INVESTMENTS, LP | 139,780 | 4,796,000 | 0.52% | ||
| 42 | Informed Momentum Co LLC | 130,265 | 4,469,000 | 0.49% | ||
| 43 | Weiss Multi-Strategy Advisers LLC | 121,000 | 4,152,000 | 0.45% | ||
| 44 | South Dakota Investment Council | 119,100 | 4,086,000 | 0.44% | ||
| 45 | Formidable Asset Management, LLC | 117,445 | 4,079,000 | 0.44% | ||
| 46 | Allianz Asset Management GmbH | 117,367 | 4,027,000 | 0.44% | ||
| 47 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 115,900 | 3,977,000 | 0.43% | Put | |
| 48 | TIAA CREF INVESTMENT MANAGEMENT LLC | 107,938 | 3,703,000 | 0.40% | ||
| 49 | HAP Trading, LLC | 99,800 | 3,424,000 | 0.37% | ||
| 50 | PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 88,785 | 3,046,000 | 0.33% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
