| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Aisling Capital LLC | 2,193,060 | 75,354,000 | 7.83% | ||
| 2 | WASATCH ADVISORS LP | 2,118,422 | 72,789,000 | 7.56% | ||
| 3 | FMR LLC | 2,048,182 | 70,376,000 | 7.31% | ||
| 4 | BB BIOTECH AG | 1,766,900 | 60,711,000 | 6.31% | ||
| 5 | VANGUARD GROUP INC | 1,588,545 | 54,582,000 | 5.67% | ||
| 6 | STATE STREET CORP | 1,483,900 | 50,986,000 | 5.30% | ||
| 7 | BlackRock Fund Advisors | 1,329,891 | 45,695,000 | 4.75% | ||
| 8 | TimesSquare Capital Management, LLC | 1,189,955 | 40,887,000 | 4.25% | ||
| 9 | ONTARIO TEACHERS PENSION PLAN BOARD | 936,382 | 32,174,000 | 3.34% | ||
| 10 | C WorldWide Group Holding A/S | 754,300 | 25,918,000 | 2.69% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 726,717 | 24,970,000 | 2.59% | ||
| 12 | PERCEPTIVE ADVISORS LLC | 572,500 | 19,671,000 | 2.04% | ||
| 13 | GOLDMAN SACHS GROUP INC | 508,564 | 17,474,000 | 1.82% | ||
| 14 | BLACKROCK ADVISORS LLC | 494,447 | 16,989,000 | 1.77% | ||
| 15 | Opaleye Management Inc. | 490,000 | 16,836,000 | 1.75% | ||
| 16 | Abingworth LLP | 428,935 | 14,738,000 | 1.53% | ||
| 17 | COLUMBIA PARTNERS L.L.C. INVESTMENT MANAGEMENT | 353,644 | 12,151,000 | 1.26% | ||
| 18 | CITADEL ADVISORS LLC | 328,311 | 11,281,000 | 1.17% | ||
| 19 | NORTHERN TRUST CORP | 316,755 | 10,883,000 | 1.13% | ||
| 20 | AXA S.A. | 312,837 | 10,749,000 | 1.12% | ||
| 21 | VOYA INVESTMENT MANAGEMENT LLC | 306,580 | 10,534,000 | 1.09% | ||
| 22 | PUTNAM INVESTMENTS LLC | 301,100 | 10,346,000 | 1.08% | ||
| 23 | HIGHLAND CAPITAL MANAGEMENT LP | 295,458 | 10,152,000 | 1.05% | ||
| 24 | Rhenman & Partners Asset Management AB | 277,161 | 9,523,000 | 0.99% | ||
| 25 | Invesco Ltd. | 250,863 | 8,620,000 | 0.90% | ||
| 26 | D. E. Shaw & Co., Inc. | 243,786 | 8,376,000 | 0.87% | ||
| 27 | WELLS FARGO & COMPANY/MN | 243,646 | 8,372,000 | 0.87% | ||
| 28 | WILLIAM HARRIS INVESTORS INC | 227,787 | 7,827,000 | 0.81% | ||
| 29 | A.R.T. Advisors, LLC | 216,921 | 7,453,000 | 0.77% | ||
| 30 | HARVEY CAPITAL MANAGEMENT INC | 218,450 | 7,294,000 | 0.76% | ||
| 31 | GEODE CAPITAL MANAGEMENT, LLC | 209,795 | 7,208,000 | 0.75% | ||
| 32 | Bank of New York Mellon Corp | 202,789 | 6,968,000 | 0.72% | ||
| 33 | MILLENNIUM MANAGEMENT LLC | 193,776 | 6,658,000 | 0.69% | ||
| 34 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 189,300 | 6,504,000 | 0.68% | Put | |
| 35 | Candriam S.C.A. | 187,000 | 6,425,000 | 0.67% | ||
| 36 | GENERAL AMERICAN INVESTORS CO INC | 170,000 | 5,841,000 | 0.61% | ||
| 37 | TIAA CREF INVESTMENT MANAGEMENT LLC | 159,431 | 5,478,000 | 0.57% | ||
| 38 | Allianz Asset Management GmbH | 154,827 | 5,319,000 | 0.55% | ||
| 39 | EVENTIDE ASSET MANAGEMENT, LLC | 153,800 | 5,285,000 | 0.55% | ||
| 40 | Fiduciary Trust Co International of Pennsylvania | 143,367 | 4,926,000 | 0.51% | ||
| 41 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 141,500 | 4,862,000 | 0.51% | Call | |
| 42 | BlackRock Investment Management, LLC | 138,977 | 4,775,000 | 0.50% | ||
| 43 | Formidable Asset Management, LLC | 137,245 | 4,716,000 | 0.49% | ||
| 44 | AQR CAPITAL MANAGEMENT LLC | 136,674 | 4,696,000 | 0.49% | ||
| 45 | Weiss Multi-Strategy Advisers LLC | 121,000 | 4,158,000 | 0.43% | ||
| 46 | South Dakota Investment Council | 119,100 | 4,092,000 | 0.43% | ||
| 47 | Numeric Investors LLC | 113,300 | 3,893,000 | 0.40% | ||
| 48 | HAP Trading, LLC | 100,200 | 3,443,000 | 0.36% | ||
| 49 | Informed Momentum Co LLC | 99,594 | 3,422,000 | 0.36% | ||
| 50 | CREDIT SUISSE AG/ | 95,633 | 3,286,000 | 0.34% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
