| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 6,595,011 | 205,303,000 | 18.57% | ||
| 2 | VANGUARD GROUP INC | 2,286,498 | 71,178,000 | 6.44% | ||
| 3 | WASATCH ADVISORS LP | 2,224,979 | 69,264,000 | 6.26% | ||
| 4 | Aisling Capital LLC | 2,193,060 | 68,270,000 | 6.18% | ||
| 5 | BB BIOTECH AG | 1,991,900 | 62,008,000 | 5.61% | ||
| 6 | TimesSquare Capital Management, LLC | 1,818,655 | 56,615,000 | 5.12% | ||
| 7 | GOLDMAN SACHS GROUP INC | 1,549,312 | 48,230,000 | 4.36% | ||
| 8 | STATE STREET CORP | 1,307,786 | 40,713,000 | 3.68% | ||
| 9 | BlackRock Fund Advisors | 1,290,980 | 40,188,000 | 3.64% | ||
| 10 | Palo Alto Investors LP | 1,175,733 | 36,601,000 | 3.31% | ||
| 11 | ONTARIO TEACHERS PENSION PLAN BOARD | 836,382 | 26,037,000 | 2.36% | ||
| 12 | BlackRock Institutional Trust Company, N.A. | 804,475 | 25,043,000 | 2.27% | ||
| 13 | C WorldWide Group Holding A/S | 786,930 | 24,497,000 | 2.22% | ||
| 14 | VOYA INVESTMENT MANAGEMENT LLC | 505,807 | 15,746,000 | 1.42% | ||
| 15 | GENERAL AMERICAN INVESTORS CO INC | 494,409 | 15,391,000 | 1.39% | ||
| 16 | AXA S.A. | 460,225 | 14,327,000 | 1.30% | ||
| 17 | Invesco Ltd. | 421,842 | 13,132,000 | 1.19% | ||
| 18 | LEVIN CAPITAL STRATEGIES, L.P. | 407,908 | 12,698,000 | 1.15% | ||
| 19 | Abingworth LLP | 383,935 | 11,948,000 | 1.08% | ||
| 20 | NORTHERN TRUST CORP | 350,713 | 10,919,000 | 0.99% | ||
| 21 | WELLS FARGO & COMPANY/MN | 307,113 | 9,561,000 | 0.86% | ||
| 22 | GOLDMAN SACHS GROUP INC | 305,900 | 9,523,000 | 0.86% | Call | |
| 23 | JPMORGAN CHASE & CO | 273,671 | 8,520,000 | 0.77% | ||
| 24 | ACUTA CAPITAL PARTNERS, LLC | 250,000 | 7,783,000 | 0.70% | ||
| 25 | GEODE CAPITAL MANAGEMENT, LLC | 229,435 | 7,142,000 | 0.65% | ||
| 26 | Rhenman & Partners Asset Management AB | 226,000 | 7,035,000 | 0.64% | ||
| 27 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 223,200 | 6,948,000 | 0.63% | Call | |
| 28 | NORGES BANK | 216,063 | 6,726,000 | 0.61% | ||
| 29 | Opaleye Management Inc. | 200,000 | 6,226,000 | 0.56% | ||
| 30 | EVENTIDE ASSET MANAGEMENT, LLC | 184,900 | 5,756,000 | 0.52% | ||
| 31 | Knoll Capital Management, LLC | 180,800 | 5,628,000 | 0.51% | ||
| 32 | Bank of New York Mellon Corp | 163,156 | 5,079,000 | 0.46% | ||
| 33 | TREDJE AP-FONDEN | 160,000 | 4,981,000 | 0.45% | ||
| 34 | PUTNAM INVESTMENTS LLC | 155,160 | 4,830,000 | 0.44% | ||
| 35 | WILLIAM HARRIS INVESTORS INC | 144,737 | 4,506,000 | 0.41% | ||
| 36 | South Dakota Investment Council | 140,700 | 4,380,000 | 0.40% | ||
| 37 | Allianz Asset Management GmbH | 137,029 | 4,276,000 | 0.39% | ||
| 38 | Fiduciary Trust Co International of Pennsylvania | 135,300 | 4,212,000 | 0.38% | ||
| 39 | GUGGENHEIM CAPITAL LLC | 134,526 | 4,188,000 | 0.38% | ||
| 40 | Candriam S.C.A. | 130,000 | 4,047,000 | 0.37% | ||
| 41 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 119,400 | 3,717,000 | 0.34% | ||
| 42 | HANDELSBANKEN FONDER AB | 118,000 | 3,673,000 | 0.33% | ||
| 43 | TIAA CREF INVESTMENT MANAGEMENT LLC | 117,391 | 3,654,000 | 0.33% | ||
| 44 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 117,200 | 3,648,000 | 0.33% | ||
| 45 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 116,214 | 3,618,000 | 0.33% | ||
| 46 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 113,700 | 3,539,000 | 0.32% | Put | |
| 47 | HARVEY CAPITAL MANAGEMENT INC | 112,250 | 3,494,000 | 0.32% | ||
| 48 | SEI INVESTMENTS CO | 110,192 | 3,431,000 | 0.31% | ||
| 49 | BlackRock Investment Management, LLC | 107,561 | 3,348,000 | 0.30% | ||
| 50 | CAPITAL FUND MANAGEMENT S.A. | 103,609 | 3,225,000 | 0.29% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
