| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 10,246,591 | 42,523,000 | 22.24% | ||
| 2 | ORBIMED ADVISORS LLC | 4,238,000 | 17,588,000 | 9.20% | ||
| 3 | ROYCE & ASSOCIATES LP | 3,725,505 | 15,461,000 | 8.09% | ||
| 4 | FMR LLC | 3,430,078 | 14,235,000 | 7.44% | ||
| 5 | BlackRock Fund Advisors | 2,664,322 | 11,057,000 | 5.78% | ||
| 6 | BlackRock Institutional Trust Company, N.A. | 2,387,565 | 9,908,000 | 5.18% | ||
| 7 | VANGUARD GROUP INC | 2,306,310 | 9,571,000 | 5.00% | ||
| 8 | DEUTSCHE BANK AG\ | 1,502,954 | 6,237,000 | 3.26% | ||
| 9 | WELLS FARGO & COMPANY/MN | 1,346,395 | 5,587,000 | 2.92% | ||
| 10 | THB ASSET MANAGEMENT | 1,319,944 | 5,477,000 | 2.86% | ||
| 11 | Cortina Asset Management, LLC | 1,289,845 | 5,353,000 | 2.80% | ||
| 12 | STATE STREET CORP | 1,157,844 | 4,806,000 | 2.51% | ||
| 13 | NORTHERN TRUST CORP | 821,178 | 3,408,000 | 1.78% | ||
| 14 | Jefferies Group LLC | 742,400 | 3,081,000 | 1.61% | Call | |
| 15 | BANK OF AMERICA CORP /DE/ | 741,750 | 3,078,000 | 1.61% | ||
| 16 | Elk Creek Partners, LLC | 637,326 | 2,645,000 | 1.38% | ||
| 17 | FRANKLIN RESOURCES INC | 592,700 | 2,460,000 | 1.29% | ||
| 18 | ORBIMED ADVISORS LLC | 500,000 | 2,075,000 | 1.09% | Call | |
| 19 | Jefferies Group LLC | 396,100 | 1,644,000 | 0.86% | Put | |
| 20 | FIDUCIARY TRUST INTERNATIONAL LLC | 388,876 | 1,614,000 | 0.84% | ||
| 21 | BARCLAYS PLC | 395,000 | 1,580,000 | 0.83% | Put | |
| 22 | GEODE CAPITAL MANAGEMENT, LLC | 358,811 | 1,489,000 | 0.78% | ||
| 23 | Bank of New York Mellon Corp | 357,960 | 1,486,000 | 0.78% | ||
| 24 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 309,990 | 1,286,000 | 0.67% | ||
| 25 | TIAA CREF INVESTMENT MANAGEMENT LLC | 305,357 | 1,267,000 | 0.66% | ||
| 26 | BARCLAYS PLC | 313,397 | 1,254,000 | 0.66% | ||
| 27 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 289,900 | 1,203,000 | 0.63% | Put | |
| 28 | Jefferies Group LLC | 252,383 | 1,047,000 | 0.55% | ||
| 29 | BlackRock Investment Management, LLC | 209,358 | 869,000 | 0.45% | ||
| 30 | STEPHENS INC /AR/ | 186,653 | 775,000 | 0.41% | ||
| 31 | MORGAN STANLEY | 152,443 | 632,000 | 0.33% | ||
| 32 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 149,100 | 619,000 | 0.32% | ||
| 33 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 132,400 | 549,000 | 0.29% | ||
| 34 | GROUP ONE TRADING LLC | 119,971 | 498,000 | 0.26% | ||
| 35 | CREDIT SUISSE AG/ | 115,143 | 479,000 | 0.25% | ||
| 36 | Janney Montgomery Scott LLC | 112,515 | 466,937 | 0.24% | ||
| 37 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 109,800 | 456,000 | 0.24% | ||
| 38 | TEACHERS ADVISORS, LLC | 104,179 | 432,000 | 0.23% | ||
| 39 | ALLIANCEBERNSTEIN L.P. | 89,700 | 372,000 | 0.19% | ||
| 40 | Steinberg Global Asset Management | 89,200 | 370,000 | 0.19% | ||
| 41 | FIRST MIDWEST BANK TRUST DIVISION | 86,690 | 360,000 | 0.19% | ||
| 42 | ProShare Advisors LLC | 79,361 | 329,000 | 0.17% | ||
| 43 | Swiss National Bank | 79,000 | 328,000 | 0.17% | ||
| 44 | VOYA INVESTMENT MANAGEMENT LLC | 68,989 | 286,000 | 0.15% | ||
| 45 | CITADEL ADVISORS LLC | 60,598 | 251,000 | 0.13% | ||
| 46 | SALZHAUER MICHAEL | 57,837 | 240,000 | 0.13% | ||
| 47 | RHUMBLINE ADVISERS | 56,486 | 234,000 | 0.12% | ||
| 48 | Nationwide Fund Advisors | 55,177 | 229,000 | 0.12% | ||
| 49 | UBS AG | 52,856 | 219,000 | 0.11% | ||
| 50 | AMERICAN INTERNATIONAL GROUP, INC. | 51,734 | 214,696 | 0.11% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
