| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 13,553,275 | 56,517,000 | 19.16% | ||
| 2 | ORBIMED ADVISORS LLC | 8,307,727 | 34,643,000 | 11.74% | ||
| 3 | PRIMECAP MANAGEMENT CO/CA/ | 7,300,000 | 30,441,000 | 10.32% | ||
| 4 | BlackRock Fund Advisors | 3,812,499 | 15,898,000 | 5.39% | ||
| 5 | ROYCE & ASSOCIATES LP | 3,145,505 | 13,117,000 | 4.45% | ||
| 6 | VANGUARD GROUP INC | 3,072,592 | 12,813,000 | 4.34% | ||
| 7 | DEUTSCHE BANK AG\ | 2,588,021 | 10,789,000 | 3.66% | ||
| 8 | BlackRock Institutional Trust Company, N.A. | 2,571,564 | 10,723,000 | 3.63% | ||
| 9 | Elk Creek Partners, LLC | 2,322,696 | 9,686,000 | 3.28% | ||
| 10 | WELLS FARGO & COMPANY/MN | 1,830,764 | 7,633,000 | 2.59% | ||
| 11 | Redmile Group, LLC | 1,647,727 | 6,871,000 | 2.33% | ||
| 12 | Cortina Asset Management, LLC | 1,525,052 | 6,359,000 | 2.16% | ||
| 13 | STATE STREET CORP | 1,413,776 | 5,898,000 | 2.00% | ||
| 14 | Jefferies Group LLC | 1,180,000 | 4,921,000 | 1.67% | Put | |
| 15 | NORTHERN TRUST CORP | 1,004,739 | 4,189,000 | 1.42% | ||
| 16 | CASTLEARK MANAGEMENT LLC | 965,025 | 4,024,000 | 1.36% | ||
| 17 | STEPHENS INC /AR/ | 810,127 | 3,378,000 | 1.15% | ||
| 18 | BANK OF AMERICA CORP /DE/ | 676,367 | 2,820,000 | 0.96% | ||
| 19 | ORACLE INVESTMENT MANAGEMENT INC | 659,900 | 2,752,000 | 0.93% | ||
| 20 | Lesa Sroufe & Co | 651,596 | 2,717,000 | 0.92% | ||
| 21 | OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 600,000 | 2,502,000 | 0.85% | ||
| 22 | Jefferies Group LLC | 585,876 | 2,443,000 | 0.83% | ||
| 23 | GEODE CAPITAL MANAGEMENT, LLC | 552,932 | 2,305,000 | 0.78% | ||
| 24 | Bank of New York Mellon Corp | 512,305 | 2,137,000 | 0.72% | ||
| 25 | DELTA LLOYD NV | 410,000 | 1,710,000 | 0.58% | ||
| 26 | TIAA CREF INVESTMENT MANAGEMENT LLC | 388,945 | 1,622,000 | 0.55% | ||
| 27 | FIDUCIARY TRUST INTERNATIONAL LLC | 388,876 | 1,622,000 | 0.55% | ||
| 28 | MORGAN STANLEY | 347,787 | 1,450,000 | 0.49% | ||
| 29 | Janney Montgomery Scott LLC | 320,464 | 1,336,000 | 0.45% | ||
| 30 | Alyeska Investment Group, L.P. | 299,900 | 1,251,000 | 0.42% | ||
| 31 | Allianz Asset Management GmbH | 290,436 | 1,211,000 | 0.41% | ||
| 32 | BlackRock Investment Management, LLC | 276,860 | 1,155,000 | 0.39% | ||
| 33 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 260,362 | 1,086,000 | 0.37% | ||
| 34 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 254,500 | 1,061,000 | 0.36% | Put | |
| 35 | ARROWGRASS CAPITAL PARTNERS (US) LP | 252,800 | 1,054,000 | 0.36% | ||
| 36 | KENNEDY CAPITAL MANAGEMENT LLC | 239,966 | 1,001,000 | 0.34% | ||
| 37 | C Partners Holding GmbH | 235,000 | 980,000 | 0.33% | ||
| 38 | FIRST MIDWEST BANK TRUST DIVISION | 218,280 | 910,000 | 0.31% | ||
| 39 | PEAK6 Group LLC | 212,100 | 884,000 | 0.30% | Put | |
| 40 | Trexquant Investment LP | 211,300 | 881,000 | 0.30% | ||
| 41 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 149,100 | 799,000 | 0.27% | ||
| 42 | Robert W. Baird & Co. Inc | 188,614 | 787,000 | 0.27% | ||
| 43 | SALZHAUER MICHAEL | 188,552 | 786,000 | 0.27% | ||
| 44 | Tygh Capital Management, Inc. | 181,190 | 756,000 | 0.26% | ||
| 45 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 173,732 | 724,000 | 0.25% | ||
| 46 | PEAK6 Group LLC | 158,836 | 662,000 | 0.22% | ||
| 47 | CREDIT SUISSE AG/ | 153,145 | 639,000 | 0.22% | ||
| 48 | WASATCH ADVISORS LP | 150,000 | 626,000 | 0.21% | ||
| 49 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 137,100 | 572,000 | 0.19% | ||
| 50 | RENAISSANCE TECHNOLOGIES LLC | 136,000 | 567,000 | 0.19% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
