| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 8,455,306 | 40,585,000 | 17.91% | ||
| 2 | FMR LLC | 4,776,199 | 22,926,000 | 10.12% | ||
| 3 | ORBIMED ADVISORS LLC | 4,238,000 | 20,342,000 | 8.98% | ||
| 4 | ROYCE & ASSOCIATES LP | 3,807,005 | 18,274,000 | 8.07% | ||
| 5 | BlackRock Fund Advisors | 2,825,485 | 13,562,000 | 5.99% | ||
| 6 | BlackRock Institutional Trust Company, N.A. | 2,322,220 | 11,147,000 | 4.92% | ||
| 7 | VANGUARD GROUP INC | 2,261,940 | 10,858,000 | 4.79% | ||
| 8 | WELLS FARGO & COMPANY/MN | 1,556,996 | 7,473,000 | 3.30% | ||
| 9 | STATE STREET CORP | 1,290,596 | 6,190,000 | 2.73% | ||
| 10 | DEUTSCHE BANK AG\ | 1,284,553 | 6,165,000 | 2.72% | ||
| 11 | THB ASSET MANAGEMENT | 1,265,534 | 6,074,000 | 2.68% | ||
| 12 | FRANKLIN RESOURCES INC | 1,142,700 | 5,485,000 | 2.42% | ||
| 13 | Cortina Asset Management, LLC | 985,073 | 4,728,000 | 2.09% | ||
| 14 | NORTHERN TRUST CORP | 972,213 | 4,667,000 | 2.06% | ||
| 15 | Jefferies Group LLC | 826,700 | 3,968,000 | 1.75% | Call | |
| 16 | BANK OF AMERICA CORP /DE/ | 714,810 | 3,431,000 | 1.51% | ||
| 17 | Redmile Group, LLC | 586,205 | 2,814,000 | 1.24% | ||
| 18 | ORBIMED ADVISORS LLC | 500,000 | 2,400,000 | 1.06% | Call | |
| 19 | Jefferies Group LLC | 393,600 | 1,889,000 | 0.83% | Put | |
| 20 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 389,900 | 1,871,000 | 0.83% | Put | |
| 21 | FIDUCIARY TRUST INTERNATIONAL LLC | 388,876 | 1,867,000 | 0.82% | ||
| 22 | GEODE CAPITAL MANAGEMENT, LLC | 354,194 | 1,700,000 | 0.75% | ||
| 23 | Bank of New York Mellon Corp | 353,610 | 1,697,000 | 0.75% | ||
| 24 | BARCLAYS PLC | 395,000 | 1,580,000 | 0.70% | Put | |
| 25 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 292,695 | 1,404,000 | 0.62% | ||
| 26 | TIAA CREF INVESTMENT MANAGEMENT LLC | 287,823 | 1,382,000 | 0.61% | ||
| 27 | Elk Creek Partners, LLC | 266,201 | 1,278,000 | 0.56% | ||
| 28 | FULLER & THALER ASSET MANAGEMENT, INC. | 253,300 | 1,216,000 | 0.54% | ||
| 29 | BARCLAYS PLC | 275,005 | 1,100,000 | 0.49% | ||
| 30 | DRIEHAUS CAPITAL MANAGEMENT LLC | 220,141 | 1,057,000 | 0.47% | ||
| 31 | BlackRock Investment Management, LLC | 193,835 | 930,000 | 0.41% | ||
| 32 | DSC Advisors, L.P. | 190,000 | 912,000 | 0.40% | ||
| 33 | STEPHENS INC /AR/ | 186,653 | 896,000 | 0.40% | ||
| 34 | CREDIT SUISSE AG/ | 174,495 | 837,000 | 0.37% | ||
| 35 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 149,100 | 691,000 | 0.30% | ||
| 36 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 126,200 | 606,000 | 0.27% | ||
| 37 | ProShare Advisors LLC | 124,509 | 598,000 | 0.26% | ||
| 38 | Janney Montgomery Scott LLC | 110,960 | 532,608 | 0.24% | ||
| 39 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 109,800 | 528,000 | 0.23% | ||
| 40 | MORGAN STANLEY | 108,117 | 519,000 | 0.23% | ||
| 41 | CITADEL ADVISORS LLC | 101,929 | 489,000 | 0.22% | ||
| 42 | TEACHERS ADVISORS, LLC | 100,594 | 483,000 | 0.21% | ||
| 43 | EVENTIDE ASSET MANAGEMENT, LLC | 97,800 | 469,000 | 0.21% | ||
| 44 | ALLIANCEBERNSTEIN L.P. | 92,100 | 442,000 | 0.20% | ||
| 45 | Steinberg Global Asset Management | 89,200 | 428,000 | 0.19% | ||
| 46 | Swiss National Bank | 79,000 | 379,000 | 0.17% | ||
| 47 | VOYA INVESTMENT MANAGEMENT LLC | 68,989 | 331,000 | 0.15% | ||
| 48 | UBS AG | 60,900 | 292,000 | 0.13% | ||
| 49 | METROPOLITAN LIFE INSURANCE CO/NY | 60,415 | 290,000 | 0.13% | ||
| 50 | Granite Investment Partners, LLC | 58,221 | 279,000 | 0.12% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
