| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 11,702,727 | 73,025,000 | 22.86% | ||
| 2 | ORBIMED ADVISORS LLC | 7,035,000 | 43,898,000 | 13.74% | ||
| 3 | ROYCE & ASSOCIATES LP | 3,455,505 | 21,562,000 | 6.75% | ||
| 4 | BlackRock Fund Advisors | 3,103,817 | 19,368,000 | 6.06% | ||
| 5 | VANGUARD GROUP INC | 2,488,434 | 15,528,000 | 4.86% | ||
| 6 | BlackRock Institutional Trust Company, N.A. | 2,378,761 | 14,843,000 | 4.65% | ||
| 7 | THB ASSET MANAGEMENT | 1,896,384 | 11,833,000 | 3.70% | ||
| 8 | DEUTSCHE BANK AG\ | 1,573,238 | 9,815,000 | 3.07% | ||
| 9 | WELLS FARGO & COMPANY/MN | 1,260,256 | 7,864,000 | 2.46% | ||
| 10 | Cortina Asset Management, LLC | 1,187,114 | 7,408,000 | 2.32% | ||
| 11 | STATE STREET CORP | 1,163,002 | 7,258,000 | 2.27% | ||
| 12 | Elk Creek Partners, LLC | 1,145,521 | 7,148,000 | 2.24% | ||
| 13 | ORACLE INVESTMENT MANAGEMENT INC | 1,018,505 | 6,355,000 | 1.99% | ||
| 14 | NORTHERN TRUST CORP | 898,203 | 5,604,000 | 1.75% | ||
| 15 | BANK OF AMERICA CORP /DE/ | 731,444 | 4,564,000 | 1.43% | ||
| 16 | Bank of New York Mellon Corp | 546,910 | 3,414,000 | 1.07% | ||
| 17 | GEODE CAPITAL MANAGEMENT, LLC | 450,063 | 2,808,000 | 0.88% | ||
| 18 | Informed Momentum Co LLC | 443,243 | 2,766,000 | 0.87% | ||
| 19 | Jefferies Group LLC | 411,000 | 2,565,000 | 0.80% | Put | |
| 20 | FIDUCIARY TRUST INTERNATIONAL LLC | 388,876 | 2,427,000 | 0.76% | ||
| 21 | DELTA LLOYD NV | 380,000 | 2,371,000 | 0.74% | ||
| 22 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 344,009 | 2,147,000 | 0.67% | ||
| 23 | ARROWGRASS CAPITAL PARTNERS (US) LP | 325,000 | 2,028,000 | 0.63% | ||
| 24 | ACUTA CAPITAL PARTNERS, LLC | 308,282 | 1,924,000 | 0.60% | ||
| 25 | MORGAN STANLEY | 304,818 | 1,902,000 | 0.60% | ||
| 26 | TIAA CREF INVESTMENT MANAGEMENT LLC | 279,142 | 1,742,000 | 0.55% | ||
| 27 | Allianz Asset Management GmbH | 276,828 | 1,727,000 | 0.54% | ||
| 28 | BlackRock Investment Management, LLC | 222,208 | 1,387,000 | 0.43% | ||
| 29 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 205,500 | 1,282,000 | 0.40% | Put | |
| 30 | CITADEL ADVISORS LLC | 200,671 | 1,252,000 | 0.39% | ||
| 31 | FIRST MIDWEST BANK TRUST DIVISION | 200,356 | 1,250,000 | 0.39% | ||
| 32 | ACUTA CAPITAL PARTNERS, LLC | 200,000 | 1,248,000 | 0.39% | Call | |
| 33 | AMERIPRISE FINANCIAL INC | 198,987 | 1,242,000 | 0.39% | ||
| 34 | STEPHENS INC /AR/ | 198,828 | 1,241,000 | 0.39% | ||
| 35 | PEAK6 Group LLC | 180,000 | 1,123,000 | 0.35% | Put | |
| 36 | Tygh Capital Management, Inc. | 158,988 | 992,000 | 0.31% | ||
| 37 | TURNER INVESTMENTS LLC | 158,370 | 988,000 | 0.31% | ||
| 38 | SALZHAUER MICHAEL | 154,837 | 966,000 | 0.30% | ||
| 39 | RUSSELL FRANK CO/ | 153,385 | 957,000 | 0.30% | ||
| 40 | CREDIT SUISSE AG/ | 152,010 | 949,000 | 0.30% | ||
| 41 | A.R.T. Advisors, LLC | 147,772 | 922,000 | 0.29% | ||
| 42 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 145,632 | 909,000 | 0.28% | ||
| 43 | Janney Montgomery Scott LLC | 135,169 | 843,455 | 0.26% | ||
| 44 | Robert W. Baird & Co. Inc | 128,925 | 805,000 | 0.25% | ||
| 45 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 149,100 | 799,000 | 0.25% | ||
| 46 | Integre Asset Management, LLC | 126,641 | 790,000 | 0.25% | ||
| 47 | D. E. Shaw & Co., Inc. | 123,620 | 771,000 | 0.24% | ||
| 48 | TEACHERS ADVISORS, LLC | 118,210 | 738,000 | 0.23% | ||
| 49 | GROUP ONE TRADING LLC | 114,420 | 714,000 | 0.22% | ||
| 50 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 109,800 | 686,000 | 0.21% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
