| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 13,553,275 | 70,341,000 | 19.29% | ||
| 2 | ORBIMED ADVISORS LLC | 8,307,727 | 43,117,000 | 11.83% | ||
| 3 | PRIMECAP MANAGEMENT CO/CA/ | 7,400,000 | 38,406,000 | 10.53% | ||
| 4 | BlackRock Fund Advisors | 3,755,677 | 19,492,000 | 5.35% | ||
| 5 | VANGUARD GROUP INC | 3,164,974 | 16,426,000 | 4.51% | ||
| 6 | ROYCE & ASSOCIATES LP | 2,801,305 | 14,539,000 | 3.99% | ||
| 7 | Jefferies Group LLC | 2,729,900 | 14,168,000 | 3.89% | Put | |
| 8 | BlackRock Institutional Trust Company, N.A. | 2,460,303 | 12,769,000 | 3.50% | ||
| 9 | Elk Creek Partners, LLC | 2,145,108 | 11,133,000 | 3.05% | ||
| 10 | WELLS FARGO & COMPANY/MN | 2,019,208 | 10,480,000 | 2.87% | ||
| 11 | DEUTSCHE BANK AG\ | 1,925,435 | 9,991,000 | 2.74% | ||
| 12 | Redmile Group, LLC | 1,603,427 | 8,322,000 | 2.28% | ||
| 13 | Cortina Asset Management, LLC | 1,487,539 | 7,720,000 | 2.12% | ||
| 14 | STATE STREET CORP | 1,399,042 | 7,259,000 | 1.99% | ||
| 15 | NORTHERN TRUST CORP | 1,018,601 | 5,287,000 | 1.45% | ||
| 16 | STEPHENS INC /AR/ | 942,848 | 4,893,000 | 1.34% | ||
| 17 | Jefferies Group LLC | 905,310 | 4,699,000 | 1.29% | ||
| 18 | Tamarack Capital Management, LLC | 865,170 | 4,490,000 | 1.23% | ||
| 19 | Lesa Sroufe & Co | 614,666 | 3,190,000 | 0.87% | ||
| 20 | BANK OF AMERICA CORP /DE/ | 607,986 | 3,156,000 | 0.87% | ||
| 21 | GEODE CAPITAL MANAGEMENT, LLC | 583,453 | 3,028,000 | 0.83% | ||
| 22 | Bank of New York Mellon Corp | 535,805 | 2,782,000 | 0.76% | ||
| 23 | NORGES BANK | 518,135 | 2,689,000 | 0.74% | ||
| 24 | OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 477,300 | 2,477,000 | 0.68% | ||
| 25 | TIAA CREF INVESTMENT MANAGEMENT LLC | 469,334 | 2,436,000 | 0.67% | ||
| 26 | FIDUCIARY TRUST INTERNATIONAL LLC | 388,876 | 2,018,000 | 0.55% | ||
| 27 | ALLIANCEBERNSTEIN L.P. | 381,200 | 1,978,000 | 0.54% | ||
| 28 | BAIRD FINANCIAL GROUP, INC. | 368,656 | 1,913,000 | 0.52% | ||
| 29 | BlackRock Investment Management, LLC | 344,074 | 1,786,000 | 0.49% | ||
| 30 | Janney Montgomery Scott LLC | 314,177 | 1,630,579 | 0.45% | ||
| 31 | Tygh Capital Management, Inc. | 273,974 | 1,422,000 | 0.39% | ||
| 32 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 243,230 | 1,262,000 | 0.35% | ||
| 33 | SALZHAUER MICHAEL | 241,242 | 1,252,000 | 0.34% | ||
| 34 | CREDIT SUISSE AG/ | 237,307 | 1,231,000 | 0.34% | ||
| 35 | PEAK6 Group LLC | 235,400 | 1,222,000 | 0.34% | Put | |
| 36 | C Partners Holding GmbH | 235,000 | 1,220,000 | 0.33% | ||
| 37 | FIRST MIDWEST BANK TRUST DIVISION | 220,780 | 1,146,000 | 0.31% | ||
| 38 | Senvest Management, LLC | 216,274 | 1,122,000 | 0.31% | ||
| 39 | Alyeska Investment Group, L.P. | 203,191 | 1,055,000 | 0.29% | ||
| 40 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 191,000 | 991,000 | 0.27% | Put | |
| 41 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 174,183 | 904,000 | 0.25% | ||
| 42 | TEACHERS ADVISORS, LLC | 158,582 | 823,000 | 0.23% | ||
| 43 | WASATCH ADVISORS LP | 150,000 | 779,000 | 0.21% | ||
| 44 | MORGAN STANLEY | 150,177 | 779,000 | 0.21% | ||
| 45 | BAMCO INC /NY/ | 150,000 | 778,000 | 0.21% | ||
| 46 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 149,100 | 774,000 | 0.21% | ||
| 47 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 137,100 | 712,000 | 0.20% | ||
| 48 | Integre Asset Management, LLC | 133,269 | 692,000 | 0.19% | ||
| 49 | NEW YORK STATE COMMON RETIREMENT FUND | 124,254 | 645,000 | 0.18% | ||
| 50 | Cannell & Co. | 105,000 | 545,000 | 0.15% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
