| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 11,940,178 | 47,880,000 | 25.33% | ||
| 2 | ORBIMED ADVISORS LLC | 7,185,000 | 28,812,000 | 15.24% | ||
| 3 | ROYCE & ASSOCIATES LP | 3,765,505 | 15,100,000 | 7.99% | ||
| 4 | BlackRock Fund Advisors | 2,666,779 | 10,694,000 | 5.66% | ||
| 5 | BlackRock Institutional Trust Company, N.A. | 2,496,273 | 10,010,000 | 5.30% | ||
| 6 | VANGUARD GROUP INC | 2,361,467 | 9,469,000 | 5.01% | ||
| 7 | THB ASSET MANAGEMENT | 1,944,484 | 7,797,000 | 4.13% | ||
| 8 | DEUTSCHE BANK AG\ | 1,694,653 | 6,794,000 | 3.59% | ||
| 9 | Cortina Asset Management, LLC | 1,325,847 | 5,317,000 | 2.81% | ||
| 10 | WELLS FARGO & COMPANY/MN | 1,266,178 | 5,077,000 | 2.69% | ||
| 11 | STATE STREET CORP | 1,149,120 | 4,605,000 | 2.44% | ||
| 12 | NORTHERN TRUST CORP | 896,147 | 3,594,000 | 1.90% | ||
| 13 | Elk Creek Partners, LLC | 770,911 | 3,091,000 | 1.64% | ||
| 14 | BANK OF AMERICA CORP /DE/ | 738,318 | 2,960,000 | 1.57% | ||
| 15 | Jefferies Group LLC | 697,100 | 2,795,000 | 1.48% | Put | |
| 16 | Jefferies Group LLC | 509,683 | 2,044,000 | 1.08% | ||
| 17 | Bank of New York Mellon Corp | 389,750 | 1,563,000 | 0.83% | ||
| 18 | GEODE CAPITAL MANAGEMENT, LLC | 388,877 | 1,559,000 | 0.82% | ||
| 19 | FIDUCIARY TRUST INTERNATIONAL LLC | 388,876 | 1,559,000 | 0.82% | ||
| 20 | TIAA CREF INVESTMENT MANAGEMENT LLC | 289,497 | 1,161,000 | 0.61% | ||
| 21 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 274,491 | 1,101,000 | 0.58% | ||
| 22 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 248,300 | 996,000 | 0.53% | Put | |
| 23 | Janney Montgomery Scott LLC | 222,624 | 892,722 | 0.47% | ||
| 24 | BlackRock Investment Management, LLC | 212,282 | 851,000 | 0.45% | ||
| 25 | MORGAN STANLEY | 192,415 | 771,000 | 0.41% | ||
| 26 | STEPHENS INC /AR/ | 181,328 | 727,000 | 0.38% | ||
| 27 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 164,000 | 658,000 | 0.35% | ||
| 28 | GROUP ONE TRADING LLC | 150,608 | 604,000 | 0.32% | ||
| 29 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 149,100 | 598,000 | 0.32% | ||
| 30 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 133,860 | 537,000 | 0.28% | ||
| 31 | Integre Asset Management, LLC | 126,629 | 508,000 | 0.27% | ||
| 32 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 125,000 | 501,000 | 0.27% | ||
| 33 | TEACHERS ADVISORS, LLC | 118,210 | 474,000 | 0.25% | ||
| 34 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 109,800 | 441,000 | 0.23% | ||
| 35 | SALZHAUER MICHAEL | 104,837 | 441,000 | 0.23% | ||
| 36 | FIRST MIDWEST BANK TRUST DIVISION | 92,630 | 371,000 | 0.20% | ||
| 37 | ALLIANCEBERNSTEIN L.P. | 89,700 | 360,000 | 0.19% | ||
| 38 | Steinberg Global Asset Management | 89,200 | 358,000 | 0.19% | ||
| 39 | Swiss National Bank | 79,000 | 317,000 | 0.17% | ||
| 40 | UBS AG | 77,392 | 310,000 | 0.16% | ||
| 41 | VOYA INVESTMENT MANAGEMENT LLC | 68,989 | 277,000 | 0.15% | ||
| 42 | ProShare Advisors LLC | 66,960 | 269,000 | 0.14% | ||
| 43 | METROPOLITAN LIFE INSURANCE CO/NY | 61,211 | 245,000 | 0.13% | ||
| 44 | Robert W. Baird & Co. Inc | 60,870 | 244,000 | 0.13% | SH | |
| 45 | CREDIT SUISSE AG/ | 58,359 | 234,000 | 0.12% | ||
| 46 | RHUMBLINE ADVISERS | 56,486 | 227,000 | 0.12% | ||
| 47 | Nationwide Fund Advisors | 55,905 | 224,000 | 0.12% | ||
| 48 | CITADEL ADVISORS LLC | 52,786 | 212,000 | 0.11% | ||
| 49 | AMERICAN INTERNATIONAL GROUP, INC. | 51,699 | 207,313 | 0.11% | ||
| 50 | Private Wealth Partners, LLC | 50,000 | 200,000 | 0.11% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
