| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 13,553,275 | 61,532,000 | 19.13% | ||
| 2 | PRIMECAP MANAGEMENT CO/CA/ | 7,500,000 | 34,050,000 | 10.59% | ||
| 3 | ORBIMED ADVISORS LLC | 6,504,400 | 29,530,000 | 9.18% | ||
| 4 | BlackRock Fund Advisors | 3,895,880 | 17,687,000 | 5.50% | ||
| 5 | WELLS FARGO & COMPANY/MN | 3,894,236 | 17,680,000 | 5.50% | ||
| 6 | VANGUARD GROUP INC | 3,383,519 | 15,362,000 | 4.78% | ||
| 7 | Elk Creek Partners, LLC | 2,854,006 | 12,957,000 | 4.03% | ||
| 8 | BlackRock Institutional Trust Company, N.A. | 2,377,669 | 10,795,000 | 3.36% | ||
| 9 | ROYCE & ASSOCIATES LP | 2,245,405 | 10,194,000 | 3.17% | ||
| 10 | DEUTSCHE BANK AG\ | 1,953,849 | 8,869,000 | 2.76% | ||
| 11 | Redmile Group, LLC | 1,603,427 | 7,280,000 | 2.26% | ||
| 12 | Jefferies Group LLC | 1,535,100 | 6,969,000 | 2.17% | Put | |
| 13 | Cortina Asset Management, LLC | 1,467,553 | 6,663,000 | 2.07% | ||
| 14 | STATE STREET CORP | 1,360,258 | 6,173,000 | 1.92% | ||
| 15 | NORTHERN TRUST CORP | 1,086,234 | 4,932,000 | 1.53% | ||
| 16 | STEPHENS INC /AR/ | 999,427 | 4,537,000 | 1.41% | ||
| 17 | Tamarack Capital Management, LLC | 900,000 | 4,086,000 | 1.27% | ||
| 18 | Rail-Splitter Capital Management, LLC | 699,752 | 3,177,000 | 0.99% | ||
| 19 | Jefferies Group LLC | 685,000 | 3,110,000 | 0.97% | Call | |
| 20 | GEODE CAPITAL MANAGEMENT, LLC | 623,886 | 2,832,000 | 0.88% | ||
| 21 | BANK OF AMERICA CORP /DE/ | 621,313 | 2,821,000 | 0.88% | ||
| 22 | Lesa Sroufe & Co | 592,092 | 2,688,000 | 0.84% | ||
| 23 | NORGES BANK | 518,135 | 2,352,000 | 0.73% | ||
| 24 | Bank of New York Mellon Corp | 495,394 | 2,249,000 | 0.70% | ||
| 25 | TIAA CREF INVESTMENT MANAGEMENT LLC | 440,874 | 2,002,000 | 0.62% | ||
| 26 | DELTA LLOYD NV | 410,000 | 1,861,000 | 0.58% | ||
| 27 | ALLIANCEBERNSTEIN L.P. | 390,100 | 1,771,000 | 0.55% | ||
| 28 | PARADIGM ASSET MANAGEMENT CO LLC | 377,500 | 1,713,850 | 0.53% | ||
| 29 | Jefferies Group LLC | 366,667 | 1,665,000 | 0.52% | ||
| 30 | MORGAN STANLEY | 347,639 | 1,578,000 | 0.49% | ||
| 31 | BlackRock Investment Management, LLC | 341,572 | 1,551,000 | 0.48% | ||
| 32 | BAIRD FINANCIAL GROUP, INC. | 333,091 | 1,512,000 | 0.47% | ||
| 33 | OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 319,900 | 1,452,000 | 0.45% | ||
| 34 | Spot Trading L.L.C | 304,100 | 1,381,000 | 0.43% | Call | |
| 35 | FIRST MIDWEST BANK TRUST DIVISION | 298,840 | 1,357,000 | 0.42% | ||
| 36 | SALZHAUER MICHAEL | 286,880 | 1,303,000 | 0.41% | ||
| 37 | Tygh Capital Management, Inc. | 263,521 | 1,196,000 | 0.37% | ||
| 38 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 249,000 | 1,130,000 | 0.35% | Put | |
| 39 | AMERIPRISE FINANCIAL INC | 226,030 | 1,026,000 | 0.32% | ||
| 40 | Alyeska Investment Group, L.P. | 223,663 | 1,015,000 | 0.32% | ||
| 41 | BAMCO INC /NY/ | 175,000 | 794,000 | 0.25% | ||
| 42 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 173,583 | 788,000 | 0.24% | ||
| 43 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 159,013 | 722,000 | 0.22% | ||
| 44 | TEACHERS ADVISORS, LLC | 158,988 | 722,000 | 0.22% | ||
| 45 | WASATCH ADVISORS LP | 150,000 | 681,000 | 0.21% | ||
| 46 | FIDUCIARY TRUST INTERNATIONAL LLC | 146,252 | 664,000 | 0.21% | ||
| 47 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 144,200 | 655,000 | 0.20% | ||
| 48 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 137,100 | 623,000 | 0.19% | ||
| 49 | Integre Asset Management, LLC | 133,215 | 605,000 | 0.19% | ||
| 50 | Swiss National Bank | 119,200 | 541,000 | 0.17% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
