| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 13,553,275 | 85,657,000 | 19.77% | ||
| 2 | PRIMECAP MANAGEMENT CO/CA/ | 7,500,000 | 47,400,000 | 10.94% | ||
| 3 | ORBIMED ADVISORS LLC | 6,504,400 | 41,108,000 | 9.49% | ||
| 4 | WELLS FARGO & COMPANY/MN | 4,901,666 | 30,979,000 | 7.15% | ||
| 5 | BlackRock Fund Advisors | 3,706,791 | 23,427,000 | 5.41% | ||
| 6 | VANGUARD GROUP INC | 3,441,262 | 21,749,000 | 5.02% | ||
| 7 | Elk Creek Partners, LLC | 3,019,460 | 19,083,000 | 4.41% | ||
| 8 | BlackRock Institutional Trust Company, N.A. | 2,543,890 | 16,077,000 | 3.71% | ||
| 9 | DEUTSCHE BANK AG\ | 1,844,580 | 11,656,000 | 2.69% | ||
| 10 | ALLIANCEBERNSTEIN L.P. | 2,488,422 | 11,297,000 | 2.61% | ||
| 11 | STATE STREET CORP | 1,419,425 | 8,971,000 | 2.07% | ||
| 12 | Cortina Asset Management, LLC | 1,361,022 | 8,602,000 | 1.99% | ||
| 13 | ROYCE & ASSOCIATES LP | 1,199,100 | 7,578,000 | 1.75% | ||
| 14 | NORTHERN TRUST CORP | 1,174,471 | 7,423,000 | 1.71% | ||
| 15 | STEPHENS INC /AR/ | 1,112,665 | 7,032,000 | 1.62% | ||
| 16 | Rail-Splitter Capital Management, LLC | 832,722 | 5,263,000 | 1.21% | ||
| 17 | BANK OF AMERICA CORP /DE/ | 651,459 | 4,117,000 | 0.95% | ||
| 18 | GEODE CAPITAL MANAGEMENT, LLC | 626,740 | 3,960,000 | 0.91% | ||
| 19 | NORGES BANK | 518,135 | 3,275,000 | 0.76% | ||
| 20 | Bank of New York Mellon Corp | 494,571 | 3,125,000 | 0.72% | ||
| 21 | Jefferies Group LLC | 465,000 | 2,939,000 | 0.68% | Call | |
| 22 | TIAA CREF INVESTMENT MANAGEMENT LLC | 440,874 | 2,786,000 | 0.64% | ||
| 23 | Jefferies Group LLC | 440,300 | 2,783,000 | 0.64% | Put | |
| 24 | Spot Trading L.L.C | 432,300 | 2,732,000 | 0.63% | Call | |
| 25 | Lesa Sroufe & Co | 425,710 | 2,690,000 | 0.62% | ||
| 26 | DRIEHAUS CAPITAL MANAGEMENT LLC | 384,509 | 2,430,000 | 0.56% | ||
| 27 | ROYAL BANK OF CANADA | 350,000 | 2,212,000 | 0.51% | Call | |
| 28 | FIRST MIDWEST BANK TRUST DIVISION | 347,017 | 2,193,000 | 0.51% | ||
| 29 | BlackRock Investment Management, LLC | 341,880 | 2,161,000 | 0.50% | ||
| 30 | BAIRD FINANCIAL GROUP, INC. | 311,816 | 1,971,000 | 0.46% | ||
| 31 | SALZHAUER MICHAEL | 310,944 | 1,966,000 | 0.45% | ||
| 32 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 296,935 | 1,877,000 | 0.43% | ||
| 33 | Walleye Trading LLC | 264,600 | 1,672,000 | 0.39% | Call | |
| 34 | FORMULA GROWTH LTD | 258,272 | 1,632,000 | 0.38% | ||
| 35 | AMERIPRISE FINANCIAL INC | 245,030 | 1,550,000 | 0.36% | ||
| 36 | Spot Trading L.L.C | 230,000 | 1,454,000 | 0.34% | Put | |
| 37 | ROYAL BANK OF CANADA | 210,000 | 1,327,000 | 0.31% | Put | |
| 38 | TEACHERS ADVISORS, LLC | 196,681 | 1,243,000 | 0.29% | ||
| 39 | Informed Momentum Co LLC | 180,287 | 1,139,000 | 0.26% | ||
| 40 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 176,709 | 1,117,000 | 0.26% | ||
| 41 | OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 165,237 | 1,044,000 | 0.24% | ||
| 42 | MORGAN STANLEY | 158,993 | 1,005,000 | 0.23% | ||
| 43 | RUSSELL FRANK CO/ | 146,975 | 949,000 | 0.22% | ||
| 44 | WASATCH ADVISORS LP | 150,000 | 948,000 | 0.22% | ||
| 45 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 144,200 | 911,000 | 0.21% | ||
| 46 | Integre Asset Management, LLC | 141,827 | 896,000 | 0.21% | ||
| 47 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 137,100 | 867,000 | 0.20% | ||
| 48 | PARADIGM ASSET MANAGEMENT CO LLC | 128,800 | 814,016 | 0.19% | ||
| 49 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 119,500 | 755,000 | 0.17% | Put | |
| 50 | Swiss National Bank | 119,200 | 753,000 | 0.17% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
