| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 6,180,700 | 79,484,000 | 16.78% | ||
| 2 | PRIMECAP MANAGEMENT CO/CA/ | 6,039,205 | 77,664,000 | 16.40% | ||
| 3 | NEA Management Company, LLC | 5,149,740 | 66,226,000 | 13.98% | ||
| 4 | Palo Alto Investors LP | 2,115,638 | 27,207,000 | 5.74% | ||
| 5 | MPM ASSET MANAGEMENT LLC | 1,729,674 | 22,244,000 | 4.70% | ||
| 6 | VANGUARD GROUP INC | 1,695,393 | 21,803,000 | 4.60% | ||
| 7 | STATE STREET CORP | 1,628,803 | 20,944,000 | 4.42% | ||
| 8 | EcoR1 Capital, LLC | 1,492,700 | 19,196,000 | 4.05% | ||
| 9 | BlackRock Fund Advisors | 1,278,065 | 16,436,000 | 3.47% | ||
| 10 | Foresite Capital Management II, LLC | 1,009,795 | 12,986,000 | 2.74% | ||
| 11 | QVT Financial LP | 653,828 | 8,408,000 | 1.78% | ||
| 12 | BALYASNY ASSET MANAGEMENT L.P. | 652,472 | 8,391,000 | 1.77% | ||
| 13 | BlackRock Institutional Trust Company, N.A. | 572,591 | 7,364,000 | 1.55% | ||
| 14 | NORGES BANK | 432,631 | 5,564,000 | 1.17% | ||
| 15 | NORTHERN TRUST CORP | 323,800 | 4,164,000 | 0.88% | ||
| 16 | Rock Springs Capital Management LP | 310,000 | 3,987,000 | 0.84% | ||
| 17 | MORGAN STANLEY | 309,790 | 3,984,000 | 0.84% | ||
| 18 | Cormorant Asset Management, LP | 266,250 | 3,424,000 | 0.72% | ||
| 19 | Tekla Capital Management LLC | 256,700 | 3,301,000 | 0.70% | ||
| 20 | JENNISON ASSOCIATES LLC | 253,668 | 3,262,000 | 0.69% | ||
| 21 | Spark Investment Management LLC | 233,600 | 3,001,000 | 0.63% | ||
| 22 | BAKER BROS. ADVISORS LP | 232,481 | 2,990,000 | 0.63% | ||
| 23 | RA CAPITAL MANAGEMENT, L.P. | 227,092 | 2,920,000 | 0.62% | ||
| 24 | GEODE CAPITAL MANAGEMENT, LLC | 162,452 | 2,089,000 | 0.44% | ||
| 25 | Candriam S.C.A. | 156,000 | 2,006,000 | 0.42% | ||
| 26 | Foresite Capital Management II, LLC | 150,000 | 1,929,000 | 0.41% | Put | |
| 27 | SPHERA FUNDS MANAGEMENT LTD. | 150,000 | 1,929,000 | 0.41% | ||
| 28 | Ghost Tree Capital, LLC | 150,000 | 1,929,000 | 0.41% | ||
| 29 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 147,000 | 1,890,000 | 0.40% | Call | |
| 30 | ACUTA CAPITAL PARTNERS, LLC | 140,000 | 1,800,000 | 0.38% | ||
| 31 | MARSHALL WACE, LLP | 133,714 | 1,720,000 | 0.36% | ||
| 32 | Bank of New York Mellon Corp | 122,913 | 1,581,000 | 0.33% | ||
| 33 | LORD, ABBETT & CO. LLC | 120,363 | 1,548,000 | 0.33% | ||
| 34 | WELLINGTON MANAGEMENT GROUP LLP | 117,843 | 1,515,000 | 0.32% | ||
| 35 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 111,500 | 1,434,000 | 0.30% | Put | |
| 36 | Iguana Healthcare Management, LLC | 110,000 | 1,415,000 | 0.30% | ||
| 37 | Alyeska Investment Group, L.P. | 108,772 | 1,399,000 | 0.30% | ||
| 38 | PEAK6 Group LLC | 100,000 | 1,286,000 | 0.27% | Call | |
| 39 | BlackRock Investment Management, LLC | 96,314 | 1,239,000 | 0.26% | ||
| 40 | TIAA CREF INVESTMENT MANAGEMENT LLC | 96,004 | 1,235,000 | 0.26% | ||
| 41 | QS Investors, LLC | 94,526 | 1,216,000 | 0.26% | ||
| 42 | PEAK6 Group LLC | 90,000 | 1,157,000 | 0.24% | Put | |
| 43 | PRINCIPAL FINANCIAL GROUP INC | 83,056 | 1,069,000 | 0.23% | ||
| 44 | GOLDMAN SACHS GROUP INC | 81,910 | 1,053,000 | 0.22% | ||
| 45 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 77,668 | 999,000 | 0.21% | ||
| 46 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 66,923 | 861,000 | 0.18% | ||
| 47 | TURNER INVESTMENTS LLC | 62,790 | 807,000 | 0.17% | ||
| 48 | NEW YORK STATE COMMON RETIREMENT FUND | 59,059 | 759,000 | 0.16% | ||
| 49 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 52,849 | 680,000 | 0.14% | ||
| 50 | STONERIDGE INVESTMENT PARTNERS LLC | 52,625 | 677,000 | 0.14% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
