| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 6,990,459 | 119,886,000 | 14.56% | ||
| 2 | PRIMECAP MANAGEMENT CO/CA/ | 6,541,327 | 112,184,000 | 13.63% | ||
| 3 | NEA Management Company, LLC | 6,260,851 | 107,374,000 | 13.04% | ||
| 4 | Palo Alto Investors LP | 4,791,051 | 82,167,000 | 9.98% | ||
| 5 | VANGUARD GROUP INC | 3,218,862 | 55,202,000 | 6.70% | ||
| 6 | BlackRock Finance, Inc. | 3,218,631 | 55,198,000 | 6.70% | ||
| 7 | JENNISON ASSOCIATES LLC | 1,933,804 | 33,165,000 | 4.03% | ||
| 8 | Foresite Capital Management II, LLC | 1,543,118 | 26,464,000 | 3.21% | ||
| 9 | DEERFIELD MANAGEMENT COMPANY, L.P. | 1,413,596 | 24,243,000 | 2.94% | ||
| 10 | FRANKLIN RESOURCES INC | 1,163,000 | 19,945,000 | 2.42% | ||
| 11 | STATE STREET CORP | 1,105,723 | 18,960,000 | 2.30% | ||
| 12 | FORESITE CAPITAL MANAGEMENT III, LLC | 681,922 | 11,695,000 | 1.42% | ||
| 13 | NORGES BANK | 618,591 | 10,609,000 | 1.29% | ||
| 14 | CQS Cayman LP | 614,300 | 10,535,000 | 1.28% | ||
| 15 | Ghost Tree Capital, LLC | 600,000 | 10,290,000 | 1.25% | ||
| 16 | Rock Springs Capital Management LP | 570,000 | 9,776,000 | 1.19% | ||
| 17 | ORACLE INVESTMENT MANAGEMENT INC | 516,940 | 8,866,000 | 1.08% | ||
| 18 | NORTHERN TRUST CORP | 504,670 | 8,655,000 | 1.05% | ||
| 19 | VOYA INVESTMENT MANAGEMENT LLC | 485,671 | 8,330,000 | 1.01% | ||
| 20 | CASDIN CAPITAL, LLC | 485,000 | 8,318,000 | 1.01% | ||
| 21 | Tekla Capital Management LLC | 362,000 | 6,208,000 | 0.75% | ||
| 22 | QVT Financial LP | 355,445 | 6,096,000 | 0.74% | ||
| 23 | GEODE CAPITAL MANAGEMENT, LLC | 337,747 | 5,792,000 | 0.70% | ||
| 24 | EVENTIDE ASSET MANAGEMENT, LLC | 275,000 | 4,716,000 | 0.57% | ||
| 25 | BAKER BROS. ADVISORS LP | 232,481 | 3,987,000 | 0.48% | ||
| 26 | MILLENNIUM MANAGEMENT LLC | 223,623 | 3,835,000 | 0.47% | ||
| 27 | Bank of New York Mellon Corp | 196,837 | 3,377,000 | 0.41% | ||
| 28 | Candriam S.C.A. | 192,000 | 3,293,000 | 0.40% | ||
| 29 | JPMORGAN CHASE & CO | 187,750 | 3,220,000 | 0.39% | ||
| 30 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 161,646 | 2,773,000 | 0.34% | ||
| 31 | Cormorant Asset Management, LP | 140,000 | 2,401,000 | 0.29% | ||
| 32 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 132,600 | 2,274,000 | 0.28% | ||
| 33 | RENAISSANCE TECHNOLOGIES LLC | 115,188 | 1,975,000 | 0.24% | ||
| 34 | TIAA CREF INVESTMENT MANAGEMENT LLC | 107,952 | 1,851,000 | 0.22% | ||
| 35 | QS Investors, LLC | 94,526 | 1,621,000 | 0.20% | ||
| 36 | PRINCIPAL FINANCIAL GROUP INC | 94,173 | 1,615,000 | 0.20% | ||
| 37 | MORGAN STANLEY | 82,513 | 1,415,000 | 0.17% | ||
| 38 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 79,241 | 1,359,000 | 0.17% | ||
| 39 | Iguana Healthcare Management, LLC | 75,000 | 1,286,000 | 0.16% | ||
| 40 | TEACHERS ADVISORS, LLC | 69,922 | 1,199,000 | 0.15% | ||
| 41 | Swiss National Bank | 66,700 | 1,144,000 | 0.14% | ||
| 42 | DIMENSIONAL FUND ADVISORS LP | 65,194 | 1,118,000 | 0.14% | ||
| 43 | DEUTSCHE BANK AG\ | 53,310 | 914,000 | 0.11% | ||
| 44 | D. E. Shaw & Co., Inc. | 50,577 | 867,000 | 0.11% | ||
| 45 | ALPS ADVISORS INC | 49,906 | 856,000 | 0.10% | ||
| 46 | CREDIT SUISSE AG/ | 49,449 | 848,000 | 0.10% | ||
| 47 | GOLDMAN SACHS GROUP INC | 48,931 | 839,000 | 0.10% | ||
| 48 | RHUMBLINE ADVISERS | 48,883 | 838,000 | 0.10% | ||
| 49 | ESSEX INVESTMENT MANAGEMENT CO LLC | 47,343 | 812,000 | 0.10% | ||
| 50 | RUSSELL INVESTMENTS GROUP, LTD. | 45,343 | 778,000 | 0.09% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
