| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 29,204,242 | 99,002,000 | 19.09% | ||
| 2 | PRICE T ROWE ASSOCIATES INC /MD/ | 19,295,340 | 65,411,000 | 12.61% | ||
| 3 | Meditor Group Ltd | 19,070,213 | 64,648,000 | 12.47% | ||
| 4 | WELLINGTON MANAGEMENT GROUP LLP | 16,240,816 | 55,057,000 | 10.62% | ||
| 5 | VANGUARD GROUP INC | 10,946,386 | 37,108,000 | 7.16% | ||
| 6 | STATE STREET CORP | 7,217,244 | 24,468,000 | 4.72% | ||
| 7 | BlackRock Fund Advisors | 6,606,408 | 22,396,000 | 4.32% | ||
| 8 | BlackRock Institutional Trust Company, N.A. | 5,678,139 | 19,249,000 | 3.71% | ||
| 9 | GOLDMAN SACHS GROUP INC | 2,842,003 | 9,634,000 | 1.86% | ||
| 10 | DEUTSCHE BANK AG\ | 2,788,049 | 9,450,000 | 1.82% | ||
| 11 | NORTHERN TRUST CORP | 2,248,478 | 7,622,000 | 1.47% | ||
| 12 | NEA Management Company, LLC | 2,207,000 | 7,482,000 | 1.44% | ||
| 13 | RENAISSANCE TECHNOLOGIES LLC | 1,658,150 | 5,621,000 | 1.08% | ||
| 14 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,535,100 | 5,204,000 | 1.00% | Put | |
| 15 | BLACKROCK ADVISORS LLC | 1,386,016 | 4,699,000 | 0.91% | ||
| 16 | NORGES BANK | 1,378,002 | 4,672,000 | 0.90% | ||
| 17 | MILLENNIUM MANAGEMENT LLC | 1,023,300 | 3,469,000 | 0.67% | ||
| 18 | Bank of New York Mellon Corp | 1,020,858 | 3,460,000 | 0.67% | ||
| 19 | AXA S.A. | 1,009,141 | 3,421,000 | 0.66% | ||
| 20 | DEERFIELD MANAGEMENT COMPANY, L.P. | 1,000,000 | 3,390,000 | 0.65% | Call | |
| 21 | BVF INC/IL | 1,000,000 | 3,390,000 | 0.65% | ||
| 22 | GEODE CAPITAL MANAGEMENT, LLC | 933,675 | 3,165,000 | 0.61% | ||
| 23 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 923,397 | 3,131,000 | 0.60% | ||
| 24 | TIAA CREF INVESTMENT MANAGEMENT LLC | 732,740 | 2,484,000 | 0.48% | ||
| 25 | ALTRINSIC GLOBAL ADVISORS LLC | 710,000 | 2,407,000 | 0.46% | ||
| 26 | BlackRock Investment Management, LLC | 643,952 | 2,183,000 | 0.42% | ||
| 27 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 635,200 | 2,154,000 | 0.42% | Call | |
| 28 | GOLDMAN SACHS GROUP INC | 574,800 | 1,949,000 | 0.38% | Call | |
| 29 | TEACHERS ADVISORS, LLC | 550,917 | 1,868,000 | 0.36% | ||
| 30 | BlackRock Group LTD | 515,102 | 1,746,000 | 0.34% | ||
| 31 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 505,077 | 1,713,000 | 0.33% | ||
| 32 | MASON STREET ADVISORS, LLC | 426,515 | 1,446,000 | 0.28% | ||
| 33 | PERCEPTIVE ADVISORS LLC | 400,000 | 1,356,000 | 0.26% | Call | |
| 34 | ALLIANCEBERNSTEIN L.P. | 396,198 | 1,343,000 | 0.26% | ||
| 35 | GUGGENHEIM CAPITAL LLC | 373,386 | 1,266,000 | 0.24% | ||
| 36 | A.R.T. Advisors, LLC | 357,347 | 1,211,000 | 0.23% | ||
| 37 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 355,434 | 1,205,000 | 0.23% | ||
| 38 | TD ASSET MANAGEMENT INC | 333,300 | 1,130,000 | 0.22% | ||
| 39 | LAZARD ASSET MANAGEMENT LLC | 325,857 | 1,104,000 | 0.21% | ||
| 40 | Zurcher Kantonalbank (Zurich Cantonalbank) | 300,000 | 1,017,000 | 0.20% | ||
| 41 | Rhenman & Partners Asset Management AB | 300,000 | 1,017,000 | 0.20% | ||
| 42 | MORGAN STANLEY | 290,712 | 985,000 | 0.19% | ||
| 43 | Nationwide Fund Advisors | 273,016 | 926,000 | 0.18% | ||
| 44 | CREDIT SUISSE AG/ | 272,869 | 926,000 | 0.18% | ||
| 45 | MARSHALL WACE, LLP | 252,971 | 858,000 | 0.17% | ||
| 46 | WELLS FARGO & COMPANY/MN | 243,757 | 827,000 | 0.16% | ||
| 47 | CITADEL ADVISORS LLC | 241,659 | 820,000 | 0.16% | ||
| 48 | NOMURA HOLDINGS INC | 230,970 | 788,000 | 0.15% | ||
| 49 | Swiss National Bank | 214,400 | 727,000 | 0.14% | ||
| 50 | ProShare Advisors LLC | 213,079 | 722,000 | 0.14% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
