| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Meditor Group Ltd | 19,070,213 | 71,704,000 | 14.82% | ||
| 2 | PRICE T ROWE ASSOCIATES INC /MD/ | 16,560,640 | 62,268,000 | 12.87% | ||
| 3 | FMR LLC | 15,321,741 | 57,610,000 | 11.91% | ||
| 4 | VANGUARD GROUP INC | 13,437,322 | 50,525,000 | 10.44% | ||
| 5 | STATE STREET CORP | 10,388,996 | 39,061,000 | 8.07% | ||
| 6 | BlackRock Fund Advisors | 7,692,122 | 28,922,000 | 5.98% | ||
| 7 | BlackRock Institutional Trust Company, N.A. | 5,923,889 | 22,274,000 | 4.60% | ||
| 8 | DEERFIELD MANAGEMENT COMPANY, L.P. | 4,000,000 | 15,040,000 | 3.11% | Put | |
| 9 | GOLDMAN SACHS GROUP INC | 3,584,768 | 13,479,000 | 2.79% | ||
| 10 | BVF INC/IL | 2,766,152 | 10,401,000 | 2.15% | ||
| 11 | CITADEL ADVISORS LLC | 2,448,559 | 9,207,000 | 1.90% | ||
| 12 | NEA Management Company, LLC | 2,207,000 | 8,298,000 | 1.72% | ||
| 13 | NORTHERN TRUST CORP | 2,097,411 | 7,886,000 | 1.63% | ||
| 14 | LAZARD ASSET MANAGEMENT LLC | 1,516,399 | 5,701,000 | 1.18% | ||
| 15 | MILLENNIUM MANAGEMENT LLC | 1,481,400 | 5,570,000 | 1.15% | Put | |
| 16 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 1,160,600 | 4,364,000 | 0.90% | Put | |
| 17 | GEODE CAPITAL MANAGEMENT, LLC | 1,153,447 | 4,336,000 | 0.90% | ||
| 18 | Bank of New York Mellon Corp | 1,116,947 | 4,200,000 | 0.87% | ||
| 19 | WELLINGTON MANAGEMENT GROUP LLP | 939,263 | 3,532,000 | 0.73% | ||
| 20 | GREAT POINT PARTNERS LLC | 745,000 | 2,801,000 | 0.58% | Put | |
| 21 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 719,074 | 2,704,000 | 0.56% | ||
| 22 | BlackRock Investment Management, LLC | 697,676 | 2,623,000 | 0.54% | ||
| 23 | TIAA CREF INVESTMENT MANAGEMENT LLC | 684,547 | 2,574,000 | 0.53% | ||
| 24 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 636,307 | 2,393,000 | 0.49% | ||
| 25 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 507,400 | 1,908,000 | 0.39% | Call | |
| 26 | CITIGROUP INC | 502,300 | 1,889,000 | 0.39% | Call | |
| 27 | GOLDMAN SACHS GROUP INC | 500,000 | 1,880,000 | 0.39% | Call | |
| 28 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 471,400 | 1,772,000 | 0.37% | Put | |
| 29 | CREDIT SUISSE AG/ | 469,218 | 1,764,000 | 0.36% | ||
| 30 | GOLDMAN SACHS GROUP INC | 409,400 | 1,539,000 | 0.32% | Put | |
| 31 | ALLIANCEBERNSTEIN L.P. | 400,398 | 1,505,000 | 0.31% | ||
| 32 | SPHERA FUNDS MANAGEMENT LTD. | 400,000 | 1,504,000 | 0.31% | ||
| 33 | TD ASSET MANAGEMENT INC | 373,500 | 1,404,000 | 0.29% | ||
| 34 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 358,018 | 1,346,000 | 0.28% | ||
| 35 | BALYASNY ASSET MANAGEMENT L.P. | 352,516 | 1,325,000 | 0.27% | ||
| 36 | AXA S.A. | 352,296 | 1,325,000 | 0.27% | ||
| 37 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 332,100 | 1,249,000 | 0.26% | Call | |
| 38 | BlackRock Group LTD | 298,717 | 1,123,000 | 0.23% | ||
| 39 | TEACHERS ADVISORS, LLC | 296,246 | 1,114,000 | 0.23% | ||
| 40 | MILLENNIUM MANAGEMENT LLC | 275,000 | 1,034,000 | 0.21% | Call | |
| 41 | A.R.T. Advisors, LLC | 260,101 | 977,000 | 0.20% | ||
| 42 | OPPENHEIMER & CO INC | 241,691 | 909,000 | 0.19% | ||
| 43 | Swiss National Bank | 221,400 | 832,000 | 0.17% | ||
| 44 | NEW YORK STATE COMMON RETIREMENT FUND | 206,055 | 775,000 | 0.16% | ||
| 45 | Teton Advisors, Inc. | 200,000 | 752,000 | 0.16% | ||
| 46 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 194,500 | 731,000 | 0.15% | ||
| 47 | MORGAN STANLEY | 189,890 | 714,000 | 0.15% | ||
| 48 | ProShare Advisors LLC | 181,365 | 682,000 | 0.14% | ||
| 49 | BANK OF AMERICA CORP /DE/ | 178,225 | 670,000 | 0.14% | ||
| 50 | Graham Capital Management, L.P. | 170,000 | 639,000 | 0.13% | Call |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
