| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Meditor Group Ltd | 19,070,213 | 49,010,000 | 15.01% | ||
| 2 | PRICE T ROWE ASSOCIATES INC /MD/ | 17,709,640 | 45,514,000 | 13.94% | ||
| 3 | FMR LLC | 16,233,341 | 41,720,000 | 12.78% | ||
| 4 | VANGUARD GROUP INC | 11,813,513 | 30,361,000 | 9.30% | ||
| 5 | STATE STREET CORP | 11,482,521 | 29,513,000 | 9.04% | ||
| 6 | BlackRock Fund Advisors | 7,473,705 | 19,207,000 | 5.88% | ||
| 7 | BlackRock Institutional Trust Company, N.A. | 6,283,899 | 16,150,000 | 4.95% | ||
| 8 | BVF INC/IL | 4,988,357 | 12,820,000 | 3.93% | ||
| 9 | DEERFIELD MANAGEMENT COMPANY, L.P. | 4,000,000 | 10,280,000 | 3.15% | Put | |
| 10 | GOLDMAN SACHS GROUP INC | 3,494,858 | 8,982,000 | 2.75% | ||
| 11 | NEA Management Company, LLC | 2,207,000 | 5,672,000 | 1.74% | ||
| 12 | NORTHERN TRUST CORP | 2,135,808 | 5,489,000 | 1.68% | ||
| 13 | MILLENNIUM MANAGEMENT LLC | 1,089,392 | 2,800,000 | 0.86% | ||
| 14 | GEODE CAPITAL MANAGEMENT, LLC | 1,089,366 | 2,798,000 | 0.86% | ||
| 15 | Bank of New York Mellon Corp | 1,083,012 | 2,784,000 | 0.85% | ||
| 16 | WELLINGTON MANAGEMENT GROUP LLP | 1,012,323 | 2,602,000 | 0.80% | ||
| 17 | NORGES BANK | 821,439 | 2,111,000 | 0.65% | ||
| 18 | TIAA CREF INVESTMENT MANAGEMENT LLC | 728,913 | 1,873,000 | 0.57% | ||
| 19 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 617,725 | 1,588,000 | 0.49% | ||
| 20 | BALYASNY ASSET MANAGEMENT L.P. | 563,600 | 1,448,000 | 0.44% | Call | |
| 21 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 562,600 | 1,446,000 | 0.44% | Call | |
| 22 | BlackRock Investment Management, LLC | 536,366 | 1,378,000 | 0.42% | ||
| 23 | SPHERA FUNDS MANAGEMENT LTD. | 500,000 | 1,285,000 | 0.39% | ||
| 24 | BARCLAYS PLC | 611,049 | 1,223,000 | 0.37% | ||
| 25 | MORGAN STANLEY | 444,873 | 1,144,000 | 0.35% | ||
| 26 | GROUP ONE TRADING LLC | 440,583 | 1,132,000 | 0.35% | ||
| 27 | CREDIT SUISSE AG/ | 405,215 | 1,041,000 | 0.32% | ||
| 28 | TD ASSET MANAGEMENT INC | 399,800 | 1,027,000 | 0.31% | ||
| 29 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 385,000 | 989,000 | 0.30% | Put | |
| 30 | ALLIANCEBERNSTEIN L.P. | 374,298 | 962,000 | 0.29% | ||
| 31 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 360,947 | 928,000 | 0.28% | ||
| 32 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 355,410 | 913,000 | 0.28% | ||
| 33 | AXA S.A. | 347,617 | 893,000 | 0.27% | ||
| 34 | ACUTA CAPITAL PARTNERS, LLC | 329,000 | 846,000 | 0.26% | Call | |
| 35 | BALYASNY ASSET MANAGEMENT L.P. | 318,535 | 819,000 | 0.25% | ||
| 36 | TEACHERS ADVISORS, LLC | 306,574 | 788,000 | 0.24% | ||
| 37 | LAZARD ASSET MANAGEMENT LLC | 302,158 | 776,000 | 0.24% | ||
| 38 | BELLEVUE ASSET MANAGEMENT AG | 300,000 | 771,000 | 0.24% | ||
| 39 | MILLENNIUM MANAGEMENT LLC | 275,000 | 707,000 | 0.22% | Call | |
| 40 | BlackRock Group LTD | 262,546 | 675,000 | 0.21% | ||
| 41 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 260,600 | 670,000 | 0.21% | Call | |
| 42 | CITADEL ADVISORS LLC | 252,515 | 649,000 | 0.20% | ||
| 43 | A.R.T. Advisors, LLC | 242,680 | 623,000 | 0.19% | ||
| 44 | BARCLAYS PLC | 280,300 | 561,000 | 0.17% | Call | |
| 45 | Swiss National Bank | 210,300 | 540,000 | 0.17% | ||
| 46 | Teton Advisors, Inc. | 200,000 | 514,000 | 0.16% | ||
| 47 | ProShare Advisors LLC | 194,899 | 501,000 | 0.15% | ||
| 48 | DEUTSCHE BANK AG\ | 188,672 | 483,000 | 0.15% | ||
| 49 | OPPENHEIMER & CO INC | 182,570 | 469,000 | 0.14% | ||
| 50 | RHUMBLINE ADVISERS | 169,080 | 435,000 | 0.13% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
