| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 33,814,661 | 189,700,000 | 21.01% | ||
| 2 | PRICE T ROWE ASSOCIATES INC /MD/ | 24,606,910 | 138,045,000 | 15.29% | ||
| 3 | Meditor Group Ltd | 22,070,213 | 123,814,000 | 13.71% | ||
| 4 | VANGUARD GROUP INC | 15,202,428 | 85,286,000 | 9.45% | ||
| 5 | BlackRock Fund Advisors | 9,081,066 | 50,945,000 | 5.64% | ||
| 6 | STATE STREET CORP | 7,785,299 | 43,676,000 | 4.84% | ||
| 7 | Invesco Ltd. | 6,537,520 | 36,675,000 | 4.06% | ||
| 8 | BlackRock Institutional Trust Company, N.A. | 4,891,744 | 27,443,000 | 3.04% | ||
| 9 | GOLDMAN SACHS GROUP INC | 2,986,442 | 16,754,000 | 1.86% | ||
| 10 | NORTHERN TRUST CORP | 2,513,333 | 14,099,000 | 1.56% | ||
| 11 | NEA Management Company, LLC | 2,207,000 | 12,381,000 | 1.37% | ||
| 12 | ACUTA CAPITAL PARTNERS, LLC | 1,880,004 | 10,547,000 | 1.17% | ||
| 13 | GREAT POINT PARTNERS LLC | 1,590,000 | 8,920,000 | 0.99% | ||
| 14 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 1,583,347 | 8,882,000 | 0.98% | ||
| 15 | GEODE CAPITAL MANAGEMENT, LLC | 1,376,465 | 7,721,000 | 0.86% | ||
| 16 | Bank of New York Mellon Corp | 1,146,282 | 6,431,000 | 0.71% | ||
| 17 | Candriam S.C.A. | 1,086,000 | 6,093,000 | 0.67% | ||
| 18 | WELLINGTON MANAGEMENT GROUP LLP | 929,403 | 5,214,000 | 0.58% | ||
| 19 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 820,000 | 4,600,000 | 0.51% | ||
| 20 | BlackRock Investment Management, LLC | 790,552 | 4,435,000 | 0.49% | ||
| 21 | TIAA CREF INVESTMENT MANAGEMENT LLC | 789,452 | 4,429,000 | 0.49% | ||
| 22 | DRIEHAUS CAPITAL MANAGEMENT LLC | 717,553 | 4,025,000 | 0.45% | ||
| 23 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 714,544 | 4,009,000 | 0.44% | ||
| 24 | TD ASSET MANAGEMENT INC | 644,200 | 3,614,000 | 0.40% | ||
| 25 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 565,100 | 3,170,000 | 0.35% | Call | |
| 26 | JPMORGAN CHASE & CO | 555,600 | 3,117,000 | 0.35% | ||
| 27 | MORGAN STANLEY | 555,375 | 3,115,000 | 0.35% | ||
| 28 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 534,721 | 3,000,000 | 0.33% | ||
| 29 | OPPENHEIMER & CO INC | 534,025 | 2,996,000 | 0.33% | ||
| 30 | BLAIR WILLIAM & CO/IL | 528,615 | 2,965,000 | 0.33% | ||
| 31 | SPHERA FUNDS MANAGEMENT LTD. | 500,000 | 2,805,000 | 0.31% | ||
| 32 | Tetragon Partners GP Ltd | 463,600 | 2,601,000 | 0.29% | ||
| 33 | LAZARD ASSET MANAGEMENT LLC | 418,802 | 2,349,000 | 0.26% | ||
| 34 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 411,118 | 2,306,000 | 0.26% | ||
| 35 | ALLIANCEBERNSTEIN L.P. | 410,478 | 2,303,000 | 0.26% | ||
| 36 | TWO SIGMA INVESTMENTS, LP | 398,492 | 2,236,000 | 0.25% | ||
| 37 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 369,100 | 2,071,000 | 0.23% | Put | |
| 38 | TEACHERS ADVISORS, LLC | 331,649 | 1,861,000 | 0.21% | ||
| 39 | AMERICAN CENTURY COMPANIES INC | 299,114 | 1,678,000 | 0.19% | ||
| 40 | Swiss National Bank | 281,200 | 1,578,000 | 0.17% | ||
| 41 | Informed Momentum Co LLC | 280,992 | 1,576,000 | 0.17% | ||
| 42 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 260,300 | 1,460,000 | 0.16% | ||
| 43 | BLACKROCK ADVISORS LLC | 250,519 | 1,405,000 | 0.16% | ||
| 44 | PDT Partners, LLC | 250,000 | 1,403,000 | 0.16% | ||
| 45 | BlackRock Group LTD | 239,225 | 1,342,000 | 0.15% | ||
| 46 | RUSSELL FRANK CO/ | 223,820 | 1,256,000 | 0.14% | ||
| 47 | NEW YORK STATE COMMON RETIREMENT FUND | 205,500 | 1,153,000 | 0.13% | ||
| 48 | CSS LLC/IL | 204,200 | 1,145,000 | 0.13% | Put | |
| 49 | TWO SIGMA ADVISERS, LP | 201,496 | 1,132,000 | 0.13% | ||
| 50 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 201,591 | 1,131,000 | 0.13% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
