| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Meditor Group Ltd | 19,070,213 | 27,461,000 | 14.23% | ||
| 2 | PRICE T ROWE ASSOCIATES INC /MD/ | 18,560,450 | 26,727,000 | 13.85% | ||
| 3 | FMR LLC | 16,535,441 | 23,811,000 | 12.34% | ||
| 4 | STATE STREET CORP | 15,244,566 | 21,952,000 | 11.38% | ||
| 5 | VANGUARD GROUP INC | 11,038,706 | 15,895,000 | 8.24% | ||
| 6 | BlackRock Fund Advisors | 7,247,853 | 10,437,000 | 5.41% | ||
| 7 | BlackRock Institutional Trust Company, N.A. | 6,304,317 | 9,078,000 | 4.71% | ||
| 8 | BVF INC/IL | 4,195,352 | 6,041,000 | 3.13% | ||
| 9 | GOLDMAN SACHS GROUP INC | 3,854,161 | 5,550,000 | 2.88% | ||
| 10 | BALYASNY ASSET MANAGEMENT L.P. | 2,406,399 | 3,465,000 | 1.80% | ||
| 11 | GREAT POINT PARTNERS LLC | 2,233,711 | 3,217,000 | 1.67% | ||
| 12 | NEA Management Company, LLC | 2,207,000 | 3,178,000 | 1.65% | ||
| 13 | NORTHERN TRUST CORP | 2,128,584 | 3,065,000 | 1.59% | ||
| 14 | MORGAN STANLEY | 1,420,933 | 2,046,000 | 1.06% | ||
| 15 | MILLENNIUM MANAGEMENT LLC | 1,401,248 | 2,018,000 | 1.05% | ||
| 16 | WELLINGTON MANAGEMENT GROUP LLP | 1,246,283 | 1,795,000 | 0.93% | ||
| 17 | Bank of New York Mellon Corp | 1,032,759 | 1,487,000 | 0.77% | ||
| 18 | DEERFIELD MANAGEMENT COMPANY, L.P. | 1,000,000 | 1,440,000 | 0.75% | Call | |
| 19 | GEODE CAPITAL MANAGEMENT, LLC | 982,697 | 1,415,000 | 0.73% | ||
| 20 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 966,600 | 1,392,000 | 0.72% | Call | |
| 21 | NORGES BANK | 941,110 | 1,355,000 | 0.70% | ||
| 22 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 929,600 | 1,339,000 | 0.69% | Put | |
| 23 | TIAA CREF INVESTMENT MANAGEMENT LLC | 744,509 | 1,072,000 | 0.56% | ||
| 24 | WOLVERINE ASSET MANAGEMENT LLC | 9,123 | 872,000 | 0.45% | Put | |
| 25 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 605,637 | 872,000 | 0.45% | ||
| 26 | GOLDMAN SACHS GROUP INC | 576,600 | 830,000 | 0.43% | Call | |
| 27 | BlackRock Investment Management, LLC | 538,659 | 776,000 | 0.40% | ||
| 28 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 503,513 | 726,000 | 0.38% | ||
| 29 | CREDIT SUISSE AG/ | 442,377 | 638,000 | 0.33% | ||
| 30 | A.R.T. Advisors, LLC | 389,697 | 561,000 | 0.29% | ||
| 31 | D. E. Shaw & Co., Inc. | 375,163 | 540,000 | 0.28% | ||
| 32 | ALLIANCEBERNSTEIN L.P. | 374,298 | 539,000 | 0.28% | ||
| 33 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 361,010 | 520,000 | 0.27% | ||
| 34 | AXA S.A. | 345,111 | 497,000 | 0.26% | ||
| 35 | TD ASSET MANAGEMENT INC | 343,500 | 495,000 | 0.26% | ||
| 36 | TEACHERS ADVISORS, LLC | 301,454 | 434,000 | 0.22% | ||
| 37 | Adamant Biomedical Investments AG | 300,000 | 432,000 | 0.22% | ||
| 38 | MILLENNIUM MANAGEMENT LLC | 300,000 | 432,000 | 0.22% | Put | |
| 39 | LAZARD ASSET MANAGEMENT LLC | 291,694 | 420,000 | 0.22% | ||
| 40 | BlackRock Group LTD | 290,873 | 418,000 | 0.22% | ||
| 41 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 194,500 | 346,000 | 0.18% | ||
| 42 | Swiss National Bank | 210,300 | 303,000 | 0.16% | ||
| 43 | Teton Advisors, Inc. | 200,000 | 288,000 | 0.15% | ||
| 44 | BARCLAYS PLC | 262,100 | 262,000 | 0.14% | Call | |
| 45 | RENAISSANCE TECHNOLOGIES LLC | 178,033 | 256,000 | 0.13% | ||
| 46 | ProShare Advisors LLC | 171,093 | 246,000 | 0.13% | ||
| 47 | STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 154,318 | 222,000 | 0.12% | ||
| 48 | METROPOLITAN LIFE INSURANCE CO/NY | 153,763 | 221,000 | 0.11% | ||
| 49 | Nationwide Fund Advisors | 151,890 | 219,000 | 0.11% | ||
| 50 | NATIXIS | 137,600 | 198,000 | 0.10% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
