| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 34,228,669 | 136,914,000 | 19.00% | ||
| 2 | PRICE T ROWE ASSOCIATES INC /MD/ | 24,964,590 | 99,858,000 | 13.86% | ||
| 3 | Meditor Group Ltd | 22,070,213 | 88,280,000 | 12.25% | ||
| 4 | VANGUARD GROUP INC | 16,082,070 | 64,328,000 | 8.93% | ||
| 5 | BlackRock Fund Advisors | 9,629,564 | 38,518,000 | 5.34% | ||
| 6 | STATE STREET CORP | 8,425,055 | 33,702,000 | 4.68% | ||
| 7 | Invesco Ltd. | 7,145,421 | 28,582,000 | 3.97% | ||
| 8 | BlackRock Institutional Trust Company, N.A. | 5,329,318 | 21,317,000 | 2.96% | ||
| 9 | GOLDMAN SACHS GROUP INC | 3,958,758 | 15,835,000 | 2.20% | ||
| 10 | GREAT POINT PARTNERS LLC | 3,896,113 | 15,584,000 | 2.16% | ||
| 11 | LAZARD ASSET MANAGEMENT LLC | 2,665,849 | 10,663,000 | 1.48% | ||
| 12 | NORTHERN TRUST CORP | 2,605,090 | 10,421,000 | 1.45% | ||
| 13 | BAKER BROS. ADVISORS LP | 2,580,000 | 10,320,000 | 1.43% | ||
| 14 | CITIGROUP INC | 2,362,335 | 9,449,000 | 1.31% | ||
| 15 | NEA Management Company, LLC | 2,207,000 | 8,828,000 | 1.22% | ||
| 16 | CITADEL ADVISORS LLC | 1,723,528 | 6,894,000 | 0.96% | ||
| 17 | GEODE CAPITAL MANAGEMENT, LLC | 1,529,148 | 6,116,000 | 0.85% | ||
| 18 | TWO SIGMA INVESTMENTS, LP | 1,504,434 | 6,018,000 | 0.84% | ||
| 19 | Tekla Capital Management LLC | 1,405,420 | 5,622,000 | 0.78% | ||
| 20 | Candriam S.C.A. | 1,410,000 | 5,610,000 | 0.78% | ||
| 21 | BANK OF AMERICA CORP /DE/ | 1,325,220 | 5,301,000 | 0.74% | ||
| 22 | DEUTSCHE BANK AG\ | 1,236,498 | 4,944,000 | 0.69% | ||
| 23 | CREDIT SUISSE AG/ | 1,149,663 | 4,598,000 | 0.64% | ||
| 24 | Bank of New York Mellon Corp | 1,101,304 | 4,405,000 | 0.61% | ||
| 25 | RENAISSANCE TECHNOLOGIES LLC | 1,008,919 | 4,036,000 | 0.56% | ||
| 26 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 939,800 | 3,759,000 | 0.52% | Call | |
| 27 | BlackRock Investment Management, LLC | 820,346 | 3,281,000 | 0.46% | ||
| 28 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 780,493 | 3,122,000 | 0.43% | ||
| 29 | TIAA CREF INVESTMENT MANAGEMENT LLC | 756,719 | 3,027,000 | 0.42% | ||
| 30 | TWO SIGMA ADVISERS, LP | 708,390 | 2,834,000 | 0.39% | ||
| 31 | Jupiter Investment Management Ltd | 707,089 | 2,828,000 | 0.39% | ||
| 32 | Rhenman & Partners Asset Management AB | 650,000 | 2,600,000 | 0.36% | ||
| 33 | TD ASSET MANAGEMENT INC | 646,500 | 2,586,000 | 0.36% | ||
| 34 | WELLINGTON MANAGEMENT GROUP LLP | 493,759 | 1,975,000 | 0.27% | ||
| 35 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 477,497 | 1,910,000 | 0.27% | ||
| 36 | BLAIR WILLIAM & CO/IL | 460,415 | 1,841,000 | 0.26% | ||
| 37 | ALLIANCEBERNSTEIN L.P. | 410,478 | 1,642,000 | 0.23% | ||
| 38 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 400,000 | 1,600,000 | 0.22% | Call | |
| 39 | TEACHERS ADVISORS, LLC | 369,498 | 1,478,000 | 0.21% | ||
| 40 | Swiss National Bank | 361,700 | 1,395,000 | 0.19% | ||
| 41 | AMERICAN CENTURY COMPANIES INC | 329,916 | 1,320,000 | 0.18% | ||
| 42 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 329,130 | 1,317,000 | 0.18% | ||
| 43 | MORGAN STANLEY | 327,441 | 1,309,000 | 0.18% | ||
| 44 | ACUTA CAPITAL PARTNERS, LLC | 320,897 | 1,284,000 | 0.18% | ||
| 45 | CSS LLC/IL | 267,800 | 1,071,000 | 0.15% | Put | |
| 46 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 253,100 | 1,012,000 | 0.14% | ||
| 47 | MILLENNIUM MANAGEMENT LLC | 248,723 | 995,000 | 0.14% | ||
| 48 | BlackRock Group LTD | 242,999 | 972,000 | 0.13% | ||
| 49 | PDT Partners, LLC | 226,345 | 905,000 | 0.13% | ||
| 50 | BLACKROCK ADVISORS LLC | 211,962 | 848,000 | 0.12% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
