| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Meditor Group Ltd | 19,070,213 | 31,466,000 | 15.33% | ||
| 2 | PRICE T ROWE ASSOCIATES INC /MD/ | 18,741,050 | 28,674,000 | 13.97% | ||
| 3 | FMR LLC | 17,135,441 | 26,217,000 | 12.77% | ||
| 4 | STATE STREET CORP | 11,494,043 | 17,582,000 | 8.56% | ||
| 5 | VANGUARD GROUP INC | 10,711,792 | 16,389,000 | 7.98% | ||
| 6 | BlackRock Fund Advisors | 6,567,461 | 10,048,000 | 4.89% | ||
| 7 | WELLINGTON MANAGEMENT GROUP LLP | 6,387,863 | 9,773,000 | 4.76% | ||
| 8 | BlackRock Institutional Trust Company, N.A. | 6,317,469 | 9,666,000 | 4.71% | ||
| 9 | GREAT POINT PARTNERS LLC | 5,100,000 | 7,803,000 | 3.80% | ||
| 10 | GOLDMAN SACHS GROUP INC | 2,992,413 | 4,578,000 | 2.23% | ||
| 11 | NEA Management Company, LLC | 2,207,000 | 3,377,000 | 1.64% | ||
| 12 | NORTHERN TRUST CORP | 2,204,627 | 3,373,000 | 1.64% | ||
| 13 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,450,400 | 2,219,000 | 1.08% | Put | |
| 14 | NORGES BANK | 1,378,002 | 2,108,000 | 1.03% | ||
| 15 | Bank of New York Mellon Corp | 1,032,114 | 1,579,000 | 0.77% | ||
| 16 | BLACKROCK ADVISORS LLC | 1,018,472 | 1,558,000 | 0.76% | ||
| 17 | DEERFIELD MANAGEMENT COMPANY, L.P. | 1,000,000 | 1,530,000 | 0.75% | Call | |
| 18 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 976,800 | 1,495,000 | 0.73% | Call | |
| 19 | GEODE CAPITAL MANAGEMENT, LLC | 966,691 | 1,479,000 | 0.72% | ||
| 20 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 917,742 | 1,404,000 | 0.68% | ||
| 21 | MILLENNIUM MANAGEMENT LLC | 808,540 | 1,237,000 | 0.60% | ||
| 22 | TIAA CREF INVESTMENT MANAGEMENT LLC | 717,220 | 1,097,000 | 0.53% | ||
| 23 | BlackRock Investment Management, LLC | 668,659 | 1,023,000 | 0.50% | ||
| 24 | WOLVERINE ASSET MANAGEMENT LLC | 9,913 | 894,000 | 0.44% | Put | |
| 25 | BlackRock Group LTD | 579,716 | 887,000 | 0.43% | ||
| 26 | GOLDMAN SACHS GROUP INC | 576,600 | 882,000 | 0.43% | Call | |
| 27 | MILLENNIUM MANAGEMENT LLC | 500,000 | 765,000 | 0.37% | Put | |
| 28 | Rhenman & Partners Asset Management AB | 500,000 | 765,000 | 0.37% | ||
| 29 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 491,435 | 752,000 | 0.37% | ||
| 30 | MASON STREET ADVISORS, LLC | 426,515 | 653,000 | 0.32% | ||
| 31 | GUGGENHEIM CAPITAL LLC | 413,407 | 633,000 | 0.31% | ||
| 32 | ALLIANCEBERNSTEIN L.P. | 396,198 | 606,000 | 0.30% | ||
| 33 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 359,474 | 550,000 | 0.27% | ||
| 34 | ALTRINSIC GLOBAL ADVISORS LLC | 349,900 | 535,000 | 0.26% | ||
| 35 | AXA S.A. | 343,514 | 526,000 | 0.26% | ||
| 36 | TD ASSET MANAGEMENT INC | 334,100 | 511,000 | 0.25% | ||
| 37 | Adamant Biomedical Investments AG | 300,000 | 459,000 | 0.22% | ||
| 38 | LAZARD ASSET MANAGEMENT LLC | 291,694 | 446,000 | 0.22% | ||
| 39 | SABBY MANAGEMENT, LLC | 281,322 | 430,000 | 0.21% | ||
| 40 | TEACHERS ADVISORS, LLC | 274,963 | 421,000 | 0.21% | ||
| 41 | D. E. Shaw & Co., Inc. | 252,198 | 386,000 | 0.19% | ||
| 42 | ROYAL BANK OF CANADA | 252,687 | 386,000 | 0.19% | ||
| 43 | Nationwide Fund Advisors | 248,231 | 380,000 | 0.19% | ||
| 44 | CREDIT SUISSE AG/ | 216,263 | 331,000 | 0.16% | ||
| 45 | Swiss National Bank | 210,300 | 322,000 | 0.16% | ||
| 46 | Teton Advisors, Inc. | 200,000 | 306,000 | 0.15% | ||
| 47 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 194,500 | 298,000 | 0.15% | ||
| 48 | BNP PARIBAS FINANCIAL MARKETS | 1,500 | 292,500 | 0.14% | Put | |
| 49 | ProShare Advisors LLC | 177,876 | 272,000 | 0.13% | ||
| 50 | MORGAN STANLEY | 172,163 | 263,000 | 0.13% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
