| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 34,082,482 | 192,225,000 | 19.27% | ||
| 2 | PRICE T ROWE ASSOCIATES INC /MD/ | 25,038,170 | 141,215,000 | 14.16% | ||
| 3 | Meditor Group Ltd | 22,070,213 | 124,476,000 | 12.48% | ||
| 4 | VANGUARD GROUP INC | 15,619,701 | 88,094,000 | 8.83% | ||
| 5 | BlackRock Fund Advisors | 9,445,533 | 53,273,000 | 5.34% | ||
| 6 | STATE STREET CORP | 8,930,765 | 50,372,000 | 5.05% | ||
| 7 | Invesco Ltd. | 8,838,523 | 49,849,000 | 5.00% | ||
| 8 | CITADEL ADVISORS LLC | 7,097,626 | 40,031,000 | 4.01% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 5,201,976 | 29,339,000 | 2.94% | ||
| 10 | GOLDMAN SACHS GROUP INC | 2,904,695 | 16,383,000 | 1.64% | ||
| 11 | NORTHERN TRUST CORP | 2,575,339 | 14,525,000 | 1.46% | ||
| 12 | NEA Management Company, LLC | 2,207,000 | 12,447,000 | 1.25% | ||
| 13 | GREAT POINT PARTNERS LLC | 2,032,494 | 11,463,000 | 1.15% | ||
| 14 | DEUTSCHE BANK AG\ | 1,916,486 | 10,808,000 | 1.08% | ||
| 15 | GEODE CAPITAL MANAGEMENT, LLC | 1,381,239 | 7,790,000 | 0.78% | ||
| 16 | ARMISTICE CAPITAL, LLC | 1,270,000 | 7,163,000 | 0.72% | ||
| 17 | ACUTA CAPITAL PARTNERS, LLC | 1,207,726 | 6,812,000 | 0.68% | ||
| 18 | LAZARD ASSET MANAGEMENT LLC | 1,173,742 | 6,619,000 | 0.66% | ||
| 19 | Bank of New York Mellon Corp | 1,093,204 | 6,167,000 | 0.62% | ||
| 20 | Tekla Capital Management LLC | 1,023,877 | 5,775,000 | 0.58% | ||
| 21 | WELLINGTON MANAGEMENT GROUP LLP | 976,687 | 5,509,000 | 0.55% | ||
| 22 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 970,500 | 5,474,000 | 0.55% | Call | |
| 23 | Candriam S.C.A. | 900,000 | 5,076,000 | 0.51% | ||
| 24 | BlackRock Investment Management, LLC | 794,714 | 4,482,000 | 0.45% | ||
| 25 | TIAA CREF INVESTMENT MANAGEMENT LLC | 768,568 | 4,335,000 | 0.43% | ||
| 26 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 763,590 | 4,307,000 | 0.43% | ||
| 27 | TWO SIGMA INVESTMENTS, LP | 697,693 | 3,935,000 | 0.39% | ||
| 28 | TD ASSET MANAGEMENT INC | 662,500 | 3,737,000 | 0.37% | ||
| 29 | UBS Group AG | 594,706 | 3,354,000 | 0.34% | ||
| 30 | RENAISSANCE TECHNOLOGIES LLC | 551,350 | 3,110,000 | 0.31% | ||
| 31 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 539,130 | 3,041,000 | 0.30% | ||
| 32 | PDT Partners, LLC | 475,200 | 2,680,000 | 0.27% | ||
| 33 | Rhenman & Partners Asset Management AB | 460,000 | 2,594,000 | 0.26% | ||
| 34 | CSS LLC/IL | 455,300 | 2,566,000 | 0.26% | Put | |
| 35 | SPHERA FUNDS MANAGEMENT LTD. | 450,000 | 2,538,000 | 0.25% | ||
| 36 | JANE STREET GROUP, LLC | 444,853 | 2,509,000 | 0.25% | ||
| 37 | BLAIR WILLIAM & CO/IL | 426,815 | 2,407,000 | 0.24% | ||
| 38 | DRIEHAUS CAPITAL MANAGEMENT LLC | 420,655 | 2,372,000 | 0.24% | ||
| 39 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 417,800 | 2,356,000 | 0.24% | ||
| 40 | ALLIANCEBERNSTEIN L.P. | 410,478 | 2,303,000 | 0.23% | ||
| 41 | TEACHERS ADVISORS, LLC | 369,498 | 2,084,000 | 0.21% | ||
| 42 | MORGAN STANLEY | 335,786 | 1,893,000 | 0.19% | ||
| 43 | AMERICAN CENTURY COMPANIES INC | 317,438 | 1,790,000 | 0.18% | ||
| 44 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 300,300 | 1,694,000 | 0.17% | ||
| 45 | Swiss National Bank | 281,200 | 1,586,000 | 0.16% | ||
| 46 | AQR CAPITAL MANAGEMENT LLC | 273,091 | 1,541,000 | 0.15% | ||
| 47 | TWO SIGMA ADVISERS, LP | 262,190 | 1,479,000 | 0.15% | ||
| 48 | Informed Momentum Co LLC | 242,313 | 1,367,000 | 0.14% | ||
| 49 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 240,300 | 1,355,000 | 0.14% | Put | |
| 50 | BlackRock Group LTD | 216,136 | 1,219,000 | 0.12% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
