| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 5,747,328 | 69,600,000 | 22.20% | ||
| 2 | Ayer Capital Management, LP | 5,604,015 | 67,865,000 | 21.65% | ||
| 3 | PERCEPTIVE ADVISORS LLC | 2,714,549 | 32,873,000 | 10.49% | ||
| 4 | Avoro Capital Advisors LLC | 2,149,907 | 26,035,000 | 8.30% | ||
| 5 | BAKER BROS. ADVISORS LP | 1,325,000 | 16,046,000 | 5.12% | ||
| 6 | QVT Financial LP | 1,325,000 | 16,046,000 | 5.12% | ||
| 7 | FRANKLIN RESOURCES INC | 1,320,000 | 15,985,000 | 5.10% | ||
| 8 | Broadfin Capital, LLC | 1,062,419 | 12,866,000 | 4.10% | ||
| 9 | ORBIMED ADVISORS LLC | 1,000,000 | 12,110,000 | 3.86% | ||
| 10 | ACUTA CAPITAL PARTNERS, LLC | 669,196 | 8,104,000 | 2.59% | ||
| 11 | Cormorant Asset Management, LP | 424,815 | 5,145,000 | 1.64% | ||
| 12 | SABBY MANAGEMENT, LLC | 375,234 | 4,544,000 | 1.45% | ||
| 13 | VANGUARD GROUP INC | 273,756 | 3,315,000 | 1.06% | ||
| 14 | UBS Group AG | 203,500 | 2,464,000 | 0.79% | ||
| 15 | Ghost Tree Capital, LLC | 200,000 | 2,422,000 | 0.77% | ||
| 16 | Opaleye Management Inc. | 200,000 | 2,422,000 | 0.77% | ||
| 17 | Boston Partners | 190,969 | 2,313,000 | 0.74% | ||
| 18 | BlackRock Institutional Trust Company, N.A. | 142,307 | 1,723,000 | 0.55% | ||
| 19 | Knoll Capital Management, LLC | 100,000 | 1,211,000 | 0.39% | ||
| 20 | BLACKROCK ADVISORS LLC | 83,786 | 1,015,000 | 0.32% | ||
| 21 | WALL STREET ASSOCIATES | 76,547 | 927,000 | 0.30% | ||
| 22 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 68,545 | 830,000 | 0.26% | ||
| 23 | P.A.W. CAPITAL CORP | 65,000 | 787,000 | 0.25% | ||
| 24 | Cubist Systematic Strategies, LLC | 53,000 | 642,000 | 0.20% | ||
| 25 | CREDIT SUISSE AG/ | 52,938 | 641,000 | 0.20% | ||
| 26 | CIBC Private Wealth Group LLC | 43,000 | 521,000 | 0.17% | ||
| 27 | LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 39,600 | 480,000 | 0.15% | ||
| 28 | GOLDMAN SACHS GROUP INC | 35,131 | 425,000 | 0.14% | ||
| 29 | Geduld E E | 35,000 | 424,000 | 0.14% | ||
| 30 | Quantitative Systematic Strategies LLC | 34,423 | 416,000 | 0.13% | ||
| 31 | COWEN INC. | 33,650 | 408,000 | 0.13% | ||
| 32 | MONASHEE INVESTMENT MANAGEMENT LLC | 31,200 | 378,000 | 0.12% | ||
| 33 | MILLENNIUM MANAGEMENT LLC | 28,110 | 340,000 | 0.11% | ||
| 34 | A.R.T. Advisors, LLC | 25,549 | 309,000 | 0.10% | ||
| 35 | DEUTSCHE BANK AG\ | 23,000 | 278,000 | 0.09% | ||
| 36 | BlueCrest Capital Management Ltd | 22,855 | 277,000 | 0.09% | ||
| 37 | TUDOR INVESTMENT CORP ET AL | 18,225 | 221,000 | 0.07% | ||
| 38 | BRANDES INVESTMENT PARTNERS, LP | 17,600 | 213,000 | 0.07% | ||
| 39 | BlackRock Group LTD | 16,835 | 204,000 | 0.07% | ||
| 40 | MORGAN STANLEY | 13,509 | 164,000 | 0.05% | ||
| 41 | TFS CAPITAL LLC | 12,548 | 152,000 | 0.05% | ||
| 42 | Edge Wealth Management LLC | 9,000 | 108,000 | 0.03% | ||
| 43 | US BANCORP \DE\ | 7,920 | 96,000 | 0.03% | ||
| 44 | Tower Research Capital LLC (TRC) | 3,765 | 45,000 | 0.01% | ||
| 45 | BlackRock Japan Co. Ltd | 3,382 | 41,000 | 0.01% | ||
| 46 | Stevens First Principles Investment Advisors | 2,000 | 24,000 | 0.01% | ||
| 47 | LADENBURG THALMANN FINANCIAL SERVICES INC. | 1,500 | 18,000 | 0.01% | ||
| 48 | PRELUDE CAPITAL MANAGEMENT, LLC | 1,200 | 15,000 | 0.00% | ||
| 49 | ROYAL BANK OF CANADA | 200 | 2,000 | 0.00% | ||
| 50 | Winch Advisory Services, LLC | 172 | 2,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
