| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 5,645,114 | 45,725,000 | 12.68% | ||
| 2 | Avoro Capital Advisors LLC | 4,338,557 | 35,142,000 | 9.75% | ||
| 3 | PERCEPTIVE ADVISORS LLC | 3,611,976 | 29,257,000 | 8.12% | ||
| 4 | ORBIMED ADVISORS LLC | 3,382,900 | 27,401,000 | 7.60% | ||
| 5 | FRANKLIN RESOURCES INC | 3,388,500 | 26,467,000 | 7.34% | ||
| 6 | ACUTA CAPITAL PARTNERS, LLC | 3,232,416 | 26,183,000 | 7.26% | ||
| 7 | Broadfin Capital, LLC | 3,170,759 | 25,683,000 | 7.12% | ||
| 8 | RS INVESTMENT MANAGEMENT CO LLC | 2,214,585 | 17,938,000 | 4.98% | ||
| 9 | BlackRock Fund Advisors | 1,807,203 | 14,638,000 | 4.06% | ||
| 10 | VANGUARD GROUP INC | 1,621,810 | 13,136,000 | 3.64% | ||
| 11 | QVT Financial LP | 1,598,309 | 12,946,000 | 3.59% | ||
| 12 | BlackRock Institutional Trust Company, N.A. | 1,141,201 | 9,244,000 | 2.56% | ||
| 13 | FRAZIER MANAGEMENT LLC | 774,720 | 6,275,000 | 1.74% | ||
| 14 | AXA S.A. | 767,761 | 6,219,000 | 1.73% | ||
| 15 | Ghost Tree Capital, LLC | 700,000 | 5,670,000 | 1.57% | ||
| 16 | STATE STREET CORP | 692,784 | 5,611,000 | 1.56% | ||
| 17 | Rhenman & Partners Asset Management AB | 650,000 | 5,265,000 | 1.46% | ||
| 18 | NORTHERN TRUST CORP | 520,759 | 4,218,000 | 1.17% | ||
| 19 | Cormorant Asset Management, LP | 505,941 | 4,098,000 | 1.14% | ||
| 20 | OXFORD ASSET MANAGEMENT LLP | 409,059 | 3,313,000 | 0.92% | ||
| 21 | SABBY MANAGEMENT, LLC | 367,242 | 2,975,000 | 0.83% | ||
| 22 | GEODE CAPITAL MANAGEMENT, LLC | 323,355 | 2,619,000 | 0.73% | ||
| 23 | GOLDMAN SACHS GROUP INC | 279,351 | 2,263,000 | 0.63% | ||
| 24 | UBS Group AG | 278,706 | 2,257,000 | 0.63% | ||
| 25 | Opaleye Management Inc. | 260,000 | 2,106,000 | 0.58% | ||
| 26 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 206,600 | 1,673,000 | 0.46% | Put | |
| 27 | Bank of New York Mellon Corp | 183,631 | 1,488,000 | 0.41% | ||
| 28 | BlackRock Investment Management, LLC | 176,831 | 1,432,000 | 0.40% | ||
| 29 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 159,377 | 1,291,000 | 0.36% | ||
| 30 | MILLENNIUM MANAGEMENT LLC | 154,631 | 1,253,000 | 0.35% | ||
| 31 | First Eagle Investment Management, LLC | 150,000 | 1,215,000 | 0.34% | ||
| 32 | TIAA CREF INVESTMENT MANAGEMENT LLC | 146,954 | 1,190,000 | 0.33% | ||
| 33 | LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 130,196 | 1,055,000 | 0.29% | ||
| 34 | GOLDMAN SACHS GROUP INC | 102,500 | 830,000 | 0.23% | Put | |
| 35 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 95,464 | 773,000 | 0.21% | ||
| 36 | Vident Investment Advisory, LLC | 85,707 | 694,000 | 0.19% | ||
| 37 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 82,200 | 666,000 | 0.18% | Call | |
| 38 | BARCLAYS PLC | 76,927 | 623,000 | 0.17% | ||
| 39 | Swiss National Bank | 74,600 | 604,000 | 0.17% | ||
| 40 | SIMPLEX TRADING, LLC | 72,340 | 585,000 | 0.16% | ||
| 41 | TEACHERS ADVISORS, LLC | 69,463 | 563,000 | 0.16% | ||
| 42 | BLACKROCK ADVISORS LLC | 64,355 | 521,000 | 0.14% | ||
| 43 | MORGAN STANLEY | 56,981 | 462,000 | 0.13% | ||
| 44 | RHUMBLINE ADVISERS | 52,276 | 423,000 | 0.12% | ||
| 45 | CREDIT SUISSE AG/ | 47,020 | 381,000 | 0.11% | ||
| 46 | CIBC Private Wealth Group LLC | 43,000 | 348,000 | 0.10% | ||
| 47 | ProShare Advisors LLC | 41,721 | 338,000 | 0.09% | ||
| 48 | NEW YORK STATE COMMON RETIREMENT FUND | 41,200 | 334,000 | 0.09% | ||
| 49 | EMERALD ACQUISITION LTD. | 40,409 | 327,000 | 0.09% | ||
| 50 | ALLIANCEBERNSTEIN L.P. | 39,600 | 321,000 | 0.09% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
