| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 5,797,328 | 53,161,000 | 16.27% | ||
| 2 | Avoro Capital Advisors LLC | 2,923,065 | 26,805,000 | 8.20% | ||
| 3 | Ayer Capital Management, LP | 2,823,333 | 25,890,000 | 7.92% | ||
| 4 | PERCEPTIVE ADVISORS LLC | 2,759,593 | 25,305,000 | 7.74% | ||
| 5 | FRANKLIN RESOURCES INC | 2,106,100 | 19,313,000 | 5.91% | ||
| 6 | BAKER BROS. ADVISORS LP | 1,817,429 | 16,666,000 | 5.10% | ||
| 7 | Broadfin Capital, LLC | 1,812,419 | 16,620,000 | 5.09% | ||
| 8 | RS INVESTMENT MANAGEMENT CO LLC | 1,675,710 | 15,366,000 | 4.70% | ||
| 9 | QVT Financial LP | 1,433,700 | 13,147,000 | 4.02% | ||
| 10 | VANGUARD GROUP INC | 1,269,233 | 11,639,000 | 3.56% | ||
| 11 | BlackRock Fund Advisors | 1,184,421 | 10,861,000 | 3.32% | ||
| 12 | BlackRock Institutional Trust Company, N.A. | 1,038,043 | 9,519,000 | 2.91% | ||
| 13 | ORBIMED ADVISORS LLC | 1,022,100 | 9,373,000 | 2.87% | ||
| 14 | ACUTA CAPITAL PARTNERS, LLC | 886,000 | 8,125,000 | 2.49% | ||
| 15 | Tourbillon Capital Partners, L.P. | 759,400 | 6,964,000 | 2.13% | ||
| 16 | Rhenman & Partners Asset Management AB | 556,000 | 5,099,000 | 1.56% | ||
| 17 | Cormorant Asset Management, LP | 499,815 | 4,583,000 | 1.40% | ||
| 18 | STATE STREET CORP | 471,489 | 4,326,000 | 1.32% | ||
| 19 | SABBY MANAGEMENT, LLC | 427,244 | 3,918,000 | 1.20% | ||
| 20 | Boston Partners | 393,801 | 3,611,000 | 1.10% | ||
| 21 | CITIGROUP INC | 375,585 | 3,444,000 | 1.05% | ||
| 22 | Ghost Tree Capital, LLC | 350,000 | 3,210,000 | 0.98% | ||
| 23 | UBS Group AG | 320,100 | 2,935,000 | 0.90% | ||
| 24 | GEODE CAPITAL MANAGEMENT, LLC | 266,880 | 2,447,000 | 0.75% | ||
| 25 | Numeric Investors LLC | 215,000 | 1,972,000 | 0.60% | ||
| 26 | Bank of New York Mellon Corp | 201,744 | 1,850,000 | 0.57% | ||
| 27 | BlackRock Investment Management, LLC | 158,645 | 1,455,000 | 0.45% | ||
| 28 | BLACKROCK ADVISORS LLC | 148,236 | 1,359,000 | 0.42% | ||
| 29 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 136,464 | 1,252,000 | 0.38% | ||
| 30 | TIAA CREF INVESTMENT MANAGEMENT LLC | 132,956 | 1,219,000 | 0.37% | ||
| 31 | NORTHERN TRUST CORP | 129,585 | 1,188,000 | 0.36% | ||
| 32 | Knoll Capital Management, LLC | 97,100 | 890,000 | 0.27% | ||
| 33 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 82,241 | 754,000 | 0.23% | ||
| 34 | P.A.W. CAPITAL CORP | 80,000 | 734,000 | 0.22% | ||
| 35 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 71,600 | 657,000 | 0.20% | Put | |
| 36 | PDT Partners, LLC | 68,814 | 631,000 | 0.19% | ||
| 37 | TEACHERS ADVISORS, LLC | 65,822 | 604,000 | 0.18% | ||
| 38 | CITADEL ADVISORS LLC | 63,781 | 585,000 | 0.18% | ||
| 39 | FEDERATED HERMES, INC. | 60,000 | 550,000 | 0.17% | ||
| 40 | Geduld E E | 60,000 | 550,000 | 0.17% | ||
| 41 | WALL STREET ASSOCIATES | 59,847 | 549,000 | 0.17% | ||
| 42 | PEAK6 Group LLC | 47,100 | 432,000 | 0.13% | Call | |
| 43 | CIBC Private Wealth Group LLC | 43,000 | 394,000 | 0.12% | ||
| 44 | LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 42,100 | 386,000 | 0.12% | ||
| 45 | METROPOLITAN LIFE INSURANCE CO/NY | 38,983 | 357,000 | 0.11% | ||
| 46 | Trellus Management Company, LLC | 38,500 | 353,000 | 0.11% | ||
| 47 | RHUMBLINE ADVISERS | 37,470 | 344,000 | 0.11% | ||
| 48 | GROUP ONE TRADING LLC | 33,506 | 307,000 | 0.09% | ||
| 49 | Visium Asset Management, LP | 32,000 | 293,000 | 0.09% | ||
| 50 | Swiss National Bank | 31,700 | 291,000 | 0.09% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
