| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 5,715,828 | 44,126,000 | 15.97% | ||
| 2 | Avoro Capital Advisors LLC | 3,187,607 | 24,608,000 | 8.91% | ||
| 3 | PERCEPTIVE ADVISORS LLC | 3,000,161 | 23,161,000 | 8.38% | ||
| 4 | RS INVESTMENT MANAGEMENT CO LLC | 2,652,860 | 20,480,000 | 7.41% | ||
| 5 | FRANKLIN RESOURCES INC | 2,178,000 | 16,814,000 | 6.08% | ||
| 6 | Broadfin Capital, LLC | 2,105,519 | 16,255,000 | 5.88% | ||
| 7 | ACUTA CAPITAL PARTNERS, LLC | 1,915,000 | 14,784,000 | 5.35% | ||
| 8 | BAKER BROS. ADVISORS LP | 1,817,429 | 14,031,000 | 5.08% | ||
| 9 | BlackRock Fund Advisors | 1,790,331 | 13,821,000 | 5.00% | ||
| 10 | VANGUARD GROUP INC | 1,510,556 | 11,661,000 | 4.22% | ||
| 11 | QVT Financial LP | 1,433,700 | 11,068,000 | 4.01% | ||
| 12 | BlackRock Institutional Trust Company, N.A. | 1,130,505 | 8,727,000 | 3.16% | ||
| 13 | ORBIMED ADVISORS LLC | 1,022,100 | 7,891,000 | 2.86% | ||
| 14 | STATE STREET CORP | 668,897 | 5,163,000 | 1.87% | ||
| 15 | Rhenman & Partners Asset Management AB | 575,000 | 4,439,000 | 1.61% | ||
| 16 | NORTHERN TRUST CORP | 506,396 | 3,910,000 | 1.41% | ||
| 17 | Cormorant Asset Management, LP | 499,815 | 3,859,000 | 1.40% | ||
| 18 | GEODE CAPITAL MANAGEMENT, LLC | 304,121 | 2,347,000 | 0.85% | ||
| 19 | UBS Group AG | 301,319 | 2,326,000 | 0.84% | ||
| 20 | OXFORD ASSET MANAGEMENT LLP | 278,184 | 2,155,000 | 0.78% | ||
| 21 | SABBY MANAGEMENT, LLC | 270,000 | 2,084,000 | 0.75% | ||
| 22 | P.A.W. CAPITAL CORP | 200,000 | 1,544,000 | 0.56% | ||
| 23 | Bank of New York Mellon Corp | 191,935 | 1,482,000 | 0.54% | ||
| 24 | BlackRock Investment Management, LLC | 156,720 | 1,210,000 | 0.44% | ||
| 25 | NEXTHERA CAPITAL LP | 152,266 | 1,175,000 | 0.43% | ||
| 26 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 151,698 | 1,172,000 | 0.42% | ||
| 27 | TIAA CREF INVESTMENT MANAGEMENT LLC | 147,023 | 1,135,000 | 0.41% | ||
| 28 | Nuveen Asset Management, LLC | 141,357 | 1,091,000 | 0.39% | ||
| 29 | Spot Trading L.L.C | 120,000 | 926,000 | 0.34% | Call | |
| 30 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 116,800 | 902,000 | 0.33% | Call | |
| 31 | Parallax Volatility Advisers, L.P. | 105,000 | 811,000 | 0.29% | Call | |
| 32 | LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 92,131 | 711,000 | 0.26% | ||
| 33 | Vident Investment Advisory, LLC | 92,153 | 711,000 | 0.26% | ||
| 34 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 83,437 | 644,000 | 0.23% | ||
| 35 | BLACKROCK ADVISORS LLC | 70,782 | 546,000 | 0.20% | ||
| 36 | PEAK6 Group LLC | 70,100 | 541,000 | 0.20% | Call | |
| 37 | TEACHERS ADVISORS, LLC | 65,822 | 508,000 | 0.18% | ||
| 38 | MORGAN STANLEY | 62,581 | 483,000 | 0.17% | ||
| 39 | Swiss National Bank | 61,600 | 476,000 | 0.17% | ||
| 40 | Trellus Management Company, LLC | 60,539 | 467,000 | 0.17% | ||
| 41 | ProShare Advisors LLC | 45,022 | 348,000 | 0.13% | ||
| 42 | RHUMBLINE ADVISERS | 44,425 | 343,000 | 0.12% | ||
| 43 | CREDIT SUISSE AG/ | 43,378 | 335,000 | 0.12% | ||
| 44 | CIBC Private Wealth Group LLC | 43,000 | 332,000 | 0.12% | ||
| 45 | NEW YORK STATE COMMON RETIREMENT FUND | 41,200 | 318,000 | 0.12% | ||
| 46 | Jefferies Group LLC | 38,000 | 293,000 | 0.11% | Call | |
| 47 | METROPOLITAN LIFE INSURANCE CO/NY | 36,097 | 279,000 | 0.10% | ||
| 48 | CITADEL ADVISORS LLC | 34,311 | 265,000 | 0.10% | ||
| 49 | Connor, Clark & Lunn Investment Management Ltd. | 31,200 | 241,000 | 0.09% | ||
| 50 | MILLENNIUM MANAGEMENT LLC | 30,596 | 236,000 | 0.09% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
