| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 5,557,812 | 45,741,000 | 11.70% | ||
| 2 | Avoro Capital Advisors LLC | 4,257,347 | 35,038,000 | 8.96% | ||
| 3 | PERCEPTIVE ADVISORS LLC | 3,567,553 | 29,360,000 | 7.51% | ||
| 4 | ORBIMED ADVISORS LLC | 3,382,900 | 27,841,000 | 7.12% | ||
| 5 | ACUTA CAPITAL PARTNERS, LLC | 3,229,916 | 26,582,000 | 6.80% | ||
| 6 | Broadfin Capital, LLC | 2,638,259 | 21,713,000 | 5.55% | ||
| 7 | VICTORY CAPITAL MANAGEMENT INC | 2,337,015 | 19,234,000 | 4.92% | ||
| 8 | BlackRock Fund Advisors | 2,248,479 | 18,505,000 | 4.73% | ||
| 9 | FRANKLIN RESOURCES INC | 2,181,100 | 17,950,000 | 4.59% | ||
| 10 | VANGUARD GROUP INC | 2,145,359 | 17,656,000 | 4.52% | ||
| 11 | FRAZIER MANAGEMENT LLC | 2,087,281 | 17,178,000 | 4.39% | ||
| 12 | QVT Financial LP | 1,751,509 | 14,335,000 | 3.67% | ||
| 13 | BLACKROCK ADVISORS LLC | 1,281,870 | 10,550,000 | 2.70% | ||
| 14 | BlackRock Institutional Trust Company, N.A. | 1,227,024 | 10,098,000 | 2.58% | ||
| 15 | Ghost Tree Capital, LLC | 825,000 | 6,790,000 | 1.74% | ||
| 16 | STATE STREET CORP | 720,363 | 5,926,000 | 1.52% | ||
| 17 | BlackRock Group LTD | 688,872 | 5,669,000 | 1.45% | ||
| 18 | AXA S.A. | 683,505 | 5,625,000 | 1.44% | ||
| 19 | Rhenman & Partners Asset Management AB | 650,000 | 5,349,500 | 1.37% | ||
| 20 | NORTHERN TRUST CORP | 595,983 | 4,905,000 | 1.25% | ||
| 21 | Cormorant Asset Management, LP | 505,941 | 4,164,000 | 1.06% | ||
| 22 | PRICE T ROWE ASSOCIATES INC /MD/ | 480,700 | 3,956,000 | 1.01% | ||
| 23 | GEODE CAPITAL MANAGEMENT, LLC | 344,959 | 2,839,000 | 0.73% | ||
| 24 | OXFORD ASSET MANAGEMENT LLP | 327,433 | 2,695,000 | 0.69% | ||
| 25 | UBS Group AG | 293,008 | 2,412,000 | 0.62% | ||
| 26 | Opaleye Management Inc. | 280,000 | 2,304,000 | 0.59% | ||
| 27 | SABBY MANAGEMENT, LLC | 246,342 | 2,027,000 | 0.52% | ||
| 28 | Allianz Asset Management GmbH | 220,375 | 1,814,000 | 0.46% | ||
| 29 | BlackRock Investment Management, LLC | 217,061 | 1,786,000 | 0.46% | ||
| 30 | Bank of New York Mellon Corp | 191,255 | 1,574,000 | 0.40% | ||
| 31 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 185,667 | 1,529,000 | 0.39% | ||
| 32 | TIAA CREF INVESTMENT MANAGEMENT LLC | 153,980 | 1,267,000 | 0.32% | ||
| 33 | First Eagle Investment Management, LLC | 150,000 | 1,235,000 | 0.32% | ||
| 34 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 138,600 | 1,141,000 | 0.29% | Put | |
| 35 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 116,700 | 960,000 | 0.25% | Call | |
| 36 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 112,464 | 926,000 | 0.24% | ||
| 37 | Vident Investment Advisory, LLC | 87,396 | 719,000 | 0.18% | ||
| 38 | TEACHERS ADVISORS, LLC | 79,399 | 653,000 | 0.17% | ||
| 39 | Swiss National Bank | 74,600 | 614,000 | 0.16% | ||
| 40 | SECOR Capital Advisors, LP | 68,756 | 566,000 | 0.14% | ||
| 41 | GOLDMAN SACHS GROUP INC | 68,550 | 564,000 | 0.14% | ||
| 42 | NEW YORK STATE COMMON RETIREMENT FUND | 51,000 | 420,000 | 0.11% | ||
| 43 | RHUMBLINE ADVISERS | 49,216 | 405,000 | 0.10% | ||
| 44 | CITADEL ADVISORS LLC | 46,740 | 385,000 | 0.10% | ||
| 45 | CREDIT SUISSE AG/ | 44,330 | 366,000 | 0.09% | ||
| 46 | CIBC Private Wealth Group LLC | 43,000 | 354,000 | 0.09% | ||
| 47 | DEUTSCHE BANK AG\ | 42,694 | 350,000 | 0.09% | ||
| 48 | ProShare Advisors LLC | 42,155 | 347,000 | 0.09% | ||
| 49 | ALLIANCEBERNSTEIN L.P. | 39,600 | 326,000 | 0.08% | ||
| 50 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 38,849 | 320,000 | 0.08% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
