| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FRANKLIN RESOURCES INC | 5,213,328 | 36,233,000 | 10.39% | ||
| 2 | Avoro Capital Advisors LLC | 4,520,643 | 31,418,000 | 9.00% | ||
| 3 | FMR LLC | 4,474,312 | 31,096,000 | 8.91% | ||
| 4 | ACUTA CAPITAL PARTNERS, LLC | 3,809,944 | 26,479,000 | 7.59% | ||
| 5 | PERCEPTIVE ADVISORS LLC | 3,567,553 | 24,794,000 | 7.11% | ||
| 6 | ORBIMED ADVISORS LLC | 3,382,900 | 23,511,000 | 6.74% | ||
| 7 | BlackRock Fund Advisors | 2,666,777 | 18,534,000 | 5.31% | ||
| 8 | Broadfin Capital, LLC | 2,638,259 | 18,336,000 | 5.26% | ||
| 9 | VICTORY CAPITAL MANAGEMENT INC | 2,340,845 | 16,269,000 | 4.66% | ||
| 10 | VANGUARD GROUP INC | 2,219,160 | 15,423,000 | 4.42% | ||
| 11 | FRAZIER MANAGEMENT LLC | 2,188,331 | 15,209,000 | 4.36% | ||
| 12 | QVT Financial LP | 1,498,809 | 10,349,000 | 2.97% | ||
| 13 | BlackRock Institutional Trust Company, N.A. | 1,268,264 | 8,814,000 | 2.53% | ||
| 14 | BLACKROCK ADVISORS LLC | 1,254,165 | 8,717,000 | 2.50% | ||
| 15 | Ghost Tree Capital, LLC | 975,000 | 6,776,000 | 1.94% | ||
| 16 | STATE STREET CORP | 863,583 | 6,004,000 | 1.72% | ||
| 17 | AXA S.A. | 696,518 | 4,841,000 | 1.39% | ||
| 18 | BlackRock Group LTD | 690,300 | 4,798,000 | 1.38% | ||
| 19 | NORTHERN TRUST CORP | 661,444 | 4,597,000 | 1.32% | ||
| 20 | Rhenman & Partners Asset Management AB | 650,000 | 4,518,000 | 1.29% | ||
| 21 | GEODE CAPITAL MANAGEMENT, LLC | 358,466 | 2,491,000 | 0.71% | ||
| 22 | Opaleye Management Inc. | 300,000 | 2,085,000 | 0.60% | ||
| 23 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 261,300 | 1,816,000 | 0.52% | Put | |
| 24 | SABBY MANAGEMENT, LLC | 226,081 | 1,571,000 | 0.45% | ||
| 25 | Bank of New York Mellon Corp | 223,223 | 1,551,000 | 0.44% | ||
| 26 | BlackRock Investment Management, LLC | 219,108 | 1,523,000 | 0.44% | ||
| 27 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 196,150 | 1,364,000 | 0.39% | ||
| 28 | Allianz Asset Management GmbH | 192,668 | 1,339,000 | 0.38% | ||
| 29 | MORGAN STANLEY | 176,613 | 1,228,000 | 0.35% | ||
| 30 | UBS Group AG | 162,770 | 1,131,000 | 0.32% | ||
| 31 | ACUTA CAPITAL PARTNERS, LLC | 150,000 | 1,043,000 | 0.30% | Call | |
| 32 | First Eagle Investment Management, LLC | 150,000 | 1,043,000 | 0.30% | ||
| 33 | TIAA CREF INVESTMENT MANAGEMENT LLC | 149,885 | 1,042,000 | 0.30% | ||
| 34 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 126,015 | 876,000 | 0.25% | ||
| 35 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 116,164 | 807,000 | 0.23% | ||
| 36 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 107,000 | 744,000 | 0.21% | Call | |
| 37 | Vident Investment Advisory, LLC | 104,616 | 727,000 | 0.21% | ||
| 38 | OXFORD ASSET MANAGEMENT LLP | 100,182 | 696,000 | 0.20% | ||
| 39 | MILLENNIUM MANAGEMENT LLC | 94,828 | 659,000 | 0.19% | ||
| 40 | TEACHERS ADVISORS, LLC | 83,424 | 580,000 | 0.17% | ||
| 41 | Swiss National Bank | 74,600 | 518,000 | 0.15% | ||
| 42 | GOLDMAN SACHS GROUP INC | 56,406 | 392,000 | 0.11% | ||
| 43 | RHUMBLINE ADVISERS | 56,249 | 391,000 | 0.11% | ||
| 44 | NEW YORK STATE COMMON RETIREMENT FUND | 51,000 | 354,000 | 0.10% | ||
| 45 | ProShare Advisors LLC | 50,083 | 348,000 | 0.10% | ||
| 46 | CIBC Private Wealth Group LLC | 43,000 | 299,000 | 0.09% | ||
| 47 | DEUTSCHE BANK AG\ | 42,914 | 297,000 | 0.09% | ||
| 48 | CITIGROUP INC | 41,933 | 291,000 | 0.08% | ||
| 49 | CITADEL ADVISORS LLC | 40,756 | 283,000 | 0.08% | ||
| 50 | ALLIANCEBERNSTEIN L.P. | 39,600 | 275,000 | 0.08% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
