| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 5,542,228 | 28,155,000 | 15.05% | ||
| 2 | Avoro Capital Advisors LLC | 3,125,198 | 15,876,000 | 8.49% | ||
| 3 | PERCEPTIVE ADVISORS LLC | 2,787,256 | 14,159,000 | 7.57% | ||
| 4 | RS INVESTMENT MANAGEMENT CO LLC | 2,694,498 | 13,688,000 | 7.32% | ||
| 5 | ACUTA CAPITAL PARTNERS, LLC | 2,500,000 | 12,700,000 | 6.79% | ||
| 6 | FRANKLIN RESOURCES INC | 2,178,000 | 11,064,000 | 5.91% | ||
| 7 | Broadfin Capital, LLC | 2,105,519 | 10,696,000 | 5.72% | ||
| 8 | BlackRock Fund Advisors | 1,784,659 | 9,066,000 | 4.85% | ||
| 9 | VANGUARD GROUP INC | 1,625,946 | 8,259,000 | 4.41% | ||
| 10 | QVT Financial LP | 1,598,309 | 8,119,000 | 4.34% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 1,126,786 | 5,724,000 | 3.06% | ||
| 12 | BAKER BROS. ADVISORS LP | 1,066,285 | 5,417,000 | 2.90% | ||
| 13 | ORBIMED ADVISORS LLC | 1,022,100 | 5,192,000 | 2.78% | ||
| 14 | AXA S.A. | 795,132 | 4,039,000 | 2.16% | ||
| 15 | STATE STREET CORP | 670,103 | 3,405,000 | 1.82% | ||
| 16 | OXFORD ASSET MANAGEMENT LLP | 604,387 | 3,070,000 | 1.64% | ||
| 17 | Rhenman & Partners Asset Management AB | 600,000 | 3,048,000 | 1.63% | ||
| 18 | NORTHERN TRUST CORP | 522,759 | 2,655,000 | 1.42% | ||
| 19 | Cormorant Asset Management, LP | 499,815 | 2,539,000 | 1.36% | ||
| 20 | SABBY MANAGEMENT, LLC | 412,246 | 2,094,000 | 1.12% | ||
| 21 | GOLDMAN SACHS GROUP INC | 410,800 | 2,087,000 | 1.12% | Call | |
| 22 | GEODE CAPITAL MANAGEMENT, LLC | 319,759 | 1,624,000 | 0.87% | ||
| 23 | UBS Group AG | 276,715 | 1,406,000 | 0.75% | ||
| 24 | Ghost Tree Capital, LLC | 250,000 | 1,270,000 | 0.68% | ||
| 25 | Bank of New York Mellon Corp | 178,630 | 907,000 | 0.48% | ||
| 26 | BlackRock Investment Management, LLC | 159,856 | 812,000 | 0.43% | ||
| 27 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 155,699 | 791,000 | 0.42% | ||
| 28 | NEXTHERA CAPITAL LP | 152,266 | 774,000 | 0.41% | ||
| 29 | TIAA CREF INVESTMENT MANAGEMENT LLC | 147,023 | 747,000 | 0.40% | ||
| 30 | LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 137,583 | 699,000 | 0.37% | ||
| 31 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 95,395 | 485,000 | 0.26% | ||
| 32 | Swiss National Bank | 74,600 | 367,000 | 0.20% | ||
| 33 | BLACKROCK ADVISORS LLC | 70,782 | 360,000 | 0.19% | ||
| 34 | PEAK6 Group LLC | 67,300 | 342,000 | 0.18% | Call | |
| 35 | MORGAN STANLEY | 66,036 | 336,000 | 0.18% | ||
| 36 | TEACHERS ADVISORS, LLC | 65,822 | 334,000 | 0.18% | ||
| 37 | GOLDMAN SACHS GROUP INC | 51,064 | 259,000 | 0.14% | ||
| 38 | Trellus Management Company, LLC | 50,000 | 254,000 | 0.14% | ||
| 39 | RHUMBLINE ADVISERS | 45,000 | 229,000 | 0.12% | ||
| 40 | CITIGROUP INC | 43,677 | 221,000 | 0.12% | ||
| 41 | CIBC Private Wealth Group LLC | 43,000 | 218,000 | 0.12% | ||
| 42 | CREDIT SUISSE AG/ | 42,187 | 215,000 | 0.11% | ||
| 43 | NEW YORK STATE COMMON RETIREMENT FUND | 41,200 | 209,000 | 0.11% | ||
| 44 | ProShare Advisors LLC | 40,657 | 207,000 | 0.11% | ||
| 45 | MILLENNIUM MANAGEMENT LLC | 36,793 | 187,000 | 0.10% | ||
| 46 | METROPOLITAN LIFE INSURANCE CO/NY | 36,097 | 183,000 | 0.10% | ||
| 47 | ELLINGTON MANAGEMENT GROUP LLC | 34,600 | 176,000 | 0.09% | ||
| 48 | Vident Investment Advisory, LLC | 897,738 | 176,000 | 0.09% | ||
| 49 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 33,900 | 172,000 | 0.09% | Put | |
| 50 | VIRTUS ETF ADVISERS LLC | 32,352 | 164,000 | 0.09% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
