| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 5,797,328 | 33,393,000 | 16.77% | ||
| 2 | Avoro Capital Advisors LLC | 3,180,913 | 18,322,000 | 9.20% | ||
| 3 | PERCEPTIVE ADVISORS LLC | 2,955,456 | 17,023,000 | 8.55% | ||
| 4 | RS INVESTMENT MANAGEMENT CO LLC | 2,346,370 | 13,515,000 | 6.79% | ||
| 5 | FRANKLIN RESOURCES INC | 2,106,100 | 12,131,000 | 6.09% | ||
| 6 | Broadfin Capital, LLC | 2,105,519 | 12,128,000 | 6.09% | ||
| 7 | BAKER BROS. ADVISORS LP | 1,817,429 | 10,468,000 | 5.26% | ||
| 8 | QVT Financial LP | 1,433,700 | 8,258,000 | 4.15% | ||
| 9 | VANGUARD GROUP INC | 1,430,956 | 8,242,000 | 4.14% | ||
| 10 | ACUTA CAPITAL PARTNERS, LLC | 1,314,959 | 7,574,000 | 3.80% | ||
| 11 | BlackRock Fund Advisors | 1,184,667 | 6,824,000 | 3.43% | ||
| 12 | BlackRock Institutional Trust Company, N.A. | 1,075,979 | 6,198,000 | 3.11% | ||
| 13 | ORBIMED ADVISORS LLC | 1,022,100 | 5,887,000 | 2.96% | ||
| 14 | Rhenman & Partners Asset Management AB | 683,108 | 3,935,000 | 1.98% | ||
| 15 | STATE STREET CORP | 582,225 | 3,355,000 | 1.68% | ||
| 16 | SABBY MANAGEMENT, LLC | 561,894 | 3,237,000 | 1.63% | ||
| 17 | Cormorant Asset Management, LP | 499,815 | 2,879,000 | 1.45% | ||
| 18 | NORTHERN TRUST CORP | 491,107 | 2,829,000 | 1.42% | ||
| 19 | CITIGROUP INC | 375,007 | 2,160,000 | 1.08% | ||
| 20 | UBS Group AG | 358,000 | 2,062,000 | 1.04% | ||
| 21 | Ghost Tree Capital, LLC | 300,000 | 1,728,000 | 0.87% | ||
| 22 | GEODE CAPITAL MANAGEMENT, LLC | 295,698 | 1,702,000 | 0.85% | ||
| 23 | WELLS FARGO & COMPANY/MN | 201,101 | 1,159,000 | 0.58% | ||
| 24 | P.A.W. CAPITAL CORP | 200,000 | 1,152,000 | 0.58% | ||
| 25 | Bank of New York Mellon Corp | 179,604 | 1,034,000 | 0.52% | ||
| 26 | BlackRock Investment Management, LLC | 155,273 | 894,000 | 0.45% | ||
| 27 | TIAA CREF INVESTMENT MANAGEMENT LLC | 154,517 | 890,000 | 0.45% | ||
| 28 | Nuveen Asset Management, LLC | 147,563 | 850,000 | 0.43% | ||
| 29 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 145,827 | 840,000 | 0.42% | ||
| 30 | Boston Partners | 97,672 | 563,000 | 0.28% | ||
| 31 | Knoll Capital Management, LLC | 97,100 | 559,000 | 0.28% | ||
| 32 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 81,941 | 472,000 | 0.24% | ||
| 33 | BLACKROCK ADVISORS LLC | 79,664 | 459,000 | 0.23% | ||
| 34 | LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 68,139 | 392,000 | 0.20% | ||
| 35 | TEACHERS ADVISORS, LLC | 65,822 | 379,000 | 0.19% | ||
| 36 | Trellus Management Company, LLC | 60,539 | 349,000 | 0.18% | ||
| 37 | FEDERATED HERMES, INC. | 60,000 | 346,000 | 0.17% | ||
| 38 | GROUP ONE TRADING LLC | 45,978 | 265,000 | 0.13% | ||
| 39 | CIBC Private Wealth Group LLC | 43,000 | 248,000 | 0.12% | ||
| 40 | MORGAN STANLEY | 41,333 | 238,000 | 0.12% | ||
| 41 | NEW YORK STATE COMMON RETIREMENT FUND | 41,200 | 237,000 | 0.12% | ||
| 42 | RHUMBLINE ADVISERS | 40,985 | 236,000 | 0.12% | ||
| 43 | Swiss National Bank | 37,800 | 218,000 | 0.11% | ||
| 44 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 35,200 | 203,000 | 0.10% | Put | |
| 45 | AQR CAPITAL MANAGEMENT LLC | 35,222 | 203,000 | 0.10% | ||
| 46 | Connor, Clark & Lunn Investment Management Ltd. | 34,700 | 200,000 | 0.10% | ||
| 47 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 34,234 | 197,000 | 0.10% | ||
| 48 | METROPOLITAN LIFE INSURANCE CO/NY | 31,855 | 183,000 | 0.09% | ||
| 49 | Visium Asset Management, LP | 30,900 | 178,000 | 0.09% | ||
| 50 | Parallax Volatility Advisers, L.P. | 30,000 | 173,000 | 0.09% | Call |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
