| 1 |
WELLINGTON MANAGEMENT GROUP LLP |
1,904,671 |
29,618,000 |
16.72% |
|
|
| 2 |
BVF INC/IL |
1,253,000 |
19,484,000 |
11.00% |
|
|
| 3 |
ORBIMED ADVISORS LLC |
1,075,400 |
16,722,000 |
9.44% |
|
|
| 4 |
TPG Group Holdings (SBS) Advisors, Inc. |
1,053,692 |
16,385,000 |
9.25% |
|
|
| 5 |
EVENTIDE ASSET MANAGEMENT, LLC |
773,600 |
12,029,000 |
6.79% |
|
|
| 6 |
QVT Financial LP |
645,705 |
10,041,000 |
5.67% |
|
|
| 7 |
GOLDMAN SACHS GROUP INC |
506,789 |
7,881,000 |
4.45% |
|
|
| 8 |
PUTNAM INVESTMENTS LLC |
444,300 |
6,909,000 |
3.90% |
|
|
| 9 |
FRANKLIN RESOURCES INC |
438,700 |
6,822,000 |
3.85% |
|
|
| 10 |
BlackRock Fund Advisors |
423,422 |
6,584,000 |
3.72% |
|
|
| 11 |
MARXE AUSTIN W & GREENHOUSE DAVID M |
300,000 |
4,665,000 |
2.63% |
|
|
| 12 |
SENZAR ASSET MANAGEMENT, LLC |
262,000 |
4,074,000 |
2.30% |
|
|
| 13 |
BlackRock Institutional Trust Company, N.A. |
248,669 |
3,867,000 |
2.18% |
|
|
| 14 |
VANGUARD GROUP INC |
247,977 |
3,856,000 |
2.18% |
|
|
| 15 |
STATE STREET CORP |
172,366 |
2,680,000 |
1.51% |
|
|
| 16 |
WELLS FARGO & COMPANY/MN |
151,733 |
2,360,000 |
1.33% |
|
|
| 17 |
PERCEPTIVE ADVISORS LLC |
150,000 |
2,333,000 |
1.32% |
|
|
| 18 |
Rock Springs Capital Management LP |
125,000 |
1,944,000 |
1.10% |
|
|
| 19 |
MILLENNIUM MANAGEMENT LLC |
107,699 |
1,675,000 |
0.95% |
|
|
| 20 |
MASON STREET ADVISORS, LLC |
96,370 |
1,499,000 |
0.85% |
|
|
| 21 |
NORTHERN TRUST CORP |
88,276 |
1,373,000 |
0.77% |
|
|
| 22 |
ADAGE CAPITAL PARTNERS GP, L.L.C. |
87,403 |
1,359,000 |
0.77% |
|
|
| 23 |
Weiss Multi-Strategy Advisers LLC |
75,000 |
1,166,000 |
0.66% |
|
|
| 24 |
Bank of New York Mellon Corp |
69,640 |
1,083,000 |
0.61% |
|
|
| 25 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
64,655 |
1,005,000 |
0.57% |
|
|
| 26 |
GEODE CAPITAL MANAGEMENT, LLC |
53,270 |
828,000 |
0.47% |
|
|
| 27 |
BlackRock Investment Management, LLC |
49,174 |
765,000 |
0.43% |
|
|
| 28 |
Granite Point Capital Management, L.P. |
40,000 |
622,000 |
0.35% |
|
|
| 29 |
TOCQUEVILLE ASSET MANAGEMENT L.P. |
38,025 |
591,000 |
0.33% |
|
|
| 30 |
Allianz Asset Management GmbH |
35,400 |
550,000 |
0.31% |
|
|
| 31 |
Nationwide Fund Advisors |
33,896 |
527,000 |
0.30% |
|
|
| 32 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
31,500 |
490,000 |
0.28% |
|
|
| 33 |
TFS CAPITAL LLC |
27,005 |
420,000 |
0.24% |
|
|
| 34 |
TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY |
26,800 |
417,000 |
0.24% |
|
|
| 35 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
25,700 |
400,000 |
0.23% |
|
|
| 36 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
25,300 |
394,000 |
0.22% |
|
|
| 37 |
TEACHERS ADVISORS, LLC |
23,987 |
373,000 |
0.21% |
|
|
| 38 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
24,000 |
373,000 |
0.21% |
|
|
| 39 |
Numeric Investors LLC |
23,900 |
372,000 |
0.21% |
|
|
| 40 |
BAKER BROS. ADVISORS LP |
19,823 |
308,000 |
0.17% |
|
|
| 41 |
MORGAN STANLEY |
17,987 |
280,000 |
0.16% |
|
|
| 42 |
METROPOLITAN LIFE INSURANCE CO/NY |
14,105 |
219,000 |
0.12% |
|
|
| 43 |
RHUMBLINE ADVISERS |
12,820 |
199,000 |
0.11% |
|
|
| 44 |
VOYA INVESTMENT MANAGEMENT LLC |
12,705 |
198,000 |
0.11% |
|
|
| 45 |
Airain ltd |
11,588 |
180,000 |
0.10% |
|
|
| 46 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
11,284 |
176,000 |
0.10% |
|
|
| 47 |
STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM |
11,293 |
176,000 |
0.10% |
|
|
| 48 |
AMERICAN INTERNATIONAL GROUP, INC. |
11,277 |
175,357 |
0.10% |
|
|
| 49 |
PNC FINANCIAL SERVICES GROUP, INC. |
11,120 |
174,000 |
0.10% |
|
|
| 50 |
CITIGROUP INC |
9,794 |
152,000 |
0.09% |
|
|
