| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | WELLINGTON MANAGEMENT GROUP LLP | 3,610,783 | 55,571,000 | 15.65% | ||
| 2 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,664,949 | 41,014,000 | 11.55% | ||
| 3 | STATE STREET CORP | 1,511,246 | 23,260,000 | 6.55% | ||
| 4 | GREAT POINT PARTNERS LLC | 1,226,785 | 18,880,000 | 5.32% | ||
| 5 | EVENTIDE ASSET MANAGEMENT, LLC | 1,164,900 | 17,928,000 | 5.05% | ||
| 6 | Versant Venture Management, LLC | 1,092,152 | 16,808,219 | 4.73% | ||
| 7 | BlackRock Fund Advisors | 933,674 | 14,369,000 | 4.05% | ||
| 8 | MILLENNIUM MANAGEMENT LLC | 750,191 | 11,545,000 | 3.25% | ||
| 9 | RTW INVESTMENTS, LP | 713,954 | 10,988,000 | 3.09% | ||
| 10 | VANGUARD GROUP INC | 647,685 | 9,968,000 | 2.81% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 642,076 | 9,882,000 | 2.78% | ||
| 12 | PRICE T ROWE ASSOCIATES INC /MD/ | 609,620 | 9,382,000 | 2.64% | ||
| 13 | ARMISTICE CAPITAL, LLC | 506,000 | 7,787,000 | 2.19% | ||
| 14 | Ghost Tree Capital, LLC | 500,000 | 7,695,000 | 2.17% | ||
| 15 | PUTNAM INVESTMENTS LLC | 491,495 | 7,564,000 | 2.13% | ||
| 16 | QVT Financial LP | 368,362 | 5,669,000 | 1.60% | ||
| 17 | BALYASNY ASSET MANAGEMENT L.P. | 336,167 | 5,174,000 | 1.46% | ||
| 18 | J. Goldman & Co LP | 313,527 | 4,825,000 | 1.36% | ||
| 19 | PERCEPTIVE ADVISORS LLC | 284,129 | 4,373,000 | 1.23% | ||
| 20 | NORTHERN TRUST CORP | 271,946 | 4,186,000 | 1.18% | ||
| 21 | DRIEHAUS CAPITAL MANAGEMENT LLC | 216,954 | 3,339,000 | 0.94% | ||
| 22 | CITADEL ADVISORS LLC | 208,745 | 3,212,000 | 0.90% | ||
| 23 | SPHERA FUNDS MANAGEMENT LTD. | 175,000 | 2,693,000 | 0.76% | ||
| 24 | MARSHALL WACE, LLP | 165,879 | 2,553,000 | 0.72% | ||
| 25 | TEACHERS ADVISORS, LLC | 154,237 | 2,374,000 | 0.67% | ||
| 26 | LORD, ABBETT & CO. LLC | 150,773 | 2,320,000 | 0.65% | ||
| 27 | EcoR1 Capital, LLC | 149,000 | 2,293,000 | 0.65% | ||
| 28 | TIAA CREF INVESTMENT MANAGEMENT LLC | 143,429 | 2,207,000 | 0.62% | ||
| 29 | GEODE CAPITAL MANAGEMENT, LLC | 137,326 | 2,113,000 | 0.60% | ||
| 30 | AQR CAPITAL MANAGEMENT LLC | 130,448 | 2,008,000 | 0.57% | ||
| 31 | Rock Springs Capital Management LP | 120,000 | 1,847,000 | 0.52% | ||
| 32 | Spark Investment Management LLC | 119,000 | 1,829,000 | 0.52% | ||
| 33 | WELLS FARGO & COMPANY/MN | 118,667 | 1,827,000 | 0.51% | ||
| 34 | AWM Investment Company, Inc. | 118,199 | 1,819,000 | 0.51% | ||
| 35 | Bank of New York Mellon Corp | 111,819 | 1,721,000 | 0.48% | ||
| 36 | GRATICULE ASIA MACRO ADVISORS LLC | 107,670 | 1,657,000 | 0.47% | ||
| 37 | Telemetry Investments, L.L.C. | 102,500 | 1,577,000 | 0.44% | ||
| 38 | Numeric Investors LLC | 100,500 | 1,547,000 | 0.44% | ||
| 39 | EverPoint Asset Management, LLC | 100,000 | 1,539,000 | 0.43% | ||
| 40 | Candriam S.C.A. | 97,300 | 1,498,000 | 0.42% | ||
| 41 | BLACKROCK ADVISORS LLC | 89,394 | 1,376,000 | 0.39% | ||
| 42 | DEUTSCHE BANK AG\ | 88,275 | 1,357,000 | 0.38% | ||
| 43 | Allianz Asset Management GmbH | 78,278 | 1,205,000 | 0.34% | ||
| 44 | BlackRock Investment Management, LLC | 75,843 | 1,167,000 | 0.33% | ||
| 45 | GSA CAPITAL PARTNERS LLP | 65,114 | 1,002,000 | 0.28% | ||
| 46 | Weiss Multi-Strategy Advisers LLC | 65,000 | 1,000,000 | 0.28% | ||
| 47 | D. E. Shaw & Co., Inc. | 56,390 | 868,000 | 0.24% | ||
| 48 | OPPENHEIMER & CO INC | 49,954 | 769,000 | 0.22% | ||
| 49 | MACQUARIE GROUP LTD | 48,000 | 739,000 | 0.21% | ||
| 50 | Nationwide Fund Advisors | 47,259 | 727,000 | 0.20% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
