| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | WELLINGTON MANAGEMENT GROUP LLP | 2,961,071 | 73,553,000 | 14.57% | ||
| 2 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,963,492 | 48,773,000 | 9.66% | ||
| 3 | STATE STREET CORP | 1,440,588 | 35,783,000 | 7.09% | ||
| 4 | Versant Venture Management, LLC | 1,092,152 | 27,129,055 | 5.37% | ||
| 5 | EVENTIDE ASSET MANAGEMENT, LLC | 957,900 | 23,794,000 | 4.71% | ||
| 6 | BlackRock Fund Advisors | 897,485 | 22,294,000 | 4.42% | ||
| 7 | GREAT POINT PARTNERS LLC | 678,595 | 16,856,000 | 3.34% | ||
| 8 | PRICE T ROWE ASSOCIATES INC /MD/ | 620,810 | 15,421,000 | 3.05% | ||
| 9 | VANGUARD GROUP INC | 573,805 | 14,253,000 | 2.82% | ||
| 10 | RTW INVESTMENTS, LP | 560,437 | 13,921,000 | 2.76% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 508,622 | 12,634,000 | 2.50% | ||
| 12 | Point72 Asset Management, L.P. | 479,411 | 11,909,000 | 2.36% | ||
| 13 | MILLENNIUM MANAGEMENT LLC | 473,569 | 11,763,000 | 2.33% | ||
| 14 | PUTNAM INVESTMENTS LLC | 446,300 | 11,086,000 | 2.20% | ||
| 15 | Ghost Tree Capital, LLC | 425,000 | 10,557,000 | 2.09% | ||
| 16 | QVT Financial LP | 406,457 | 10,096,000 | 2.00% | ||
| 17 | BANK OF MONTREAL /CAN/ | 341,210 | 8,476,000 | 1.68% | ||
| 18 | LORD, ABBETT & CO. LLC | 275,866 | 6,852,000 | 1.36% | ||
| 19 | DRIEHAUS CAPITAL MANAGEMENT LLC | 241,846 | 6,007,000 | 1.19% | ||
| 20 | BVF INC/IL | 240,597 | 5,976,000 | 1.18% | ||
| 21 | EverPoint Asset Management, LLC | 240,000 | 5,962,000 | 1.18% | ||
| 22 | Aureus Asset Management, LLC | 239,190 | 5,941,000 | 1.18% | ||
| 23 | BNP PARIBAS FINANCIAL MARKETS | 235,999 | 5,862,215 | 1.16% | ||
| 24 | NORTHERN TRUST CORP | 234,928 | 5,836,000 | 1.16% | ||
| 25 | PERCEPTIVE ADVISORS LLC | 224,129 | 5,567,000 | 1.10% | ||
| 26 | D. E. Shaw & Co., Inc. | 202,759 | 5,036,000 | 1.00% | ||
| 27 | Numeric Investors LLC | 172,368 | 4,282,000 | 0.85% | ||
| 28 | AQR CAPITAL MANAGEMENT LLC | 167,378 | 4,158,000 | 0.82% | ||
| 29 | RENAISSANCE TECHNOLOGIES LLC | 164,600 | 4,089,000 | 0.81% | ||
| 30 | TEACHERS ADVISORS, LLC | 154,237 | 3,831,000 | 0.76% | ||
| 31 | WELLS FARGO & COMPANY/MN | 149,850 | 3,722,000 | 0.74% | ||
| 32 | TIAA CREF INVESTMENT MANAGEMENT LLC | 145,343 | 3,610,000 | 0.72% | ||
| 33 | Spark Investment Management LLC | 135,000 | 3,348,000 | 0.66% | ||
| 34 | GEODE CAPITAL MANAGEMENT, LLC | 129,487 | 3,216,000 | 0.64% | ||
| 35 | SPHERA FUNDS MANAGEMENT LTD. | 125,000 | 3,105,000 | 0.62% | ||
| 36 | Bank of New York Mellon Corp | 124,968 | 3,103,000 | 0.61% | ||
| 37 | Rock Springs Capital Management LP | 120,000 | 2,981,000 | 0.59% | ||
| 38 | AWM Investment Company, Inc. | 118,199 | 2,936,000 | 0.58% | ||
| 39 | J. Goldman & Co LP | 106,537 | 2,646,000 | 0.52% | ||
| 40 | BLACKROCK ADVISORS LLC | 90,732 | 2,254,000 | 0.45% | ||
| 41 | DEUTSCHE BANK AG\ | 87,399 | 2,169,000 | 0.43% | ||
| 42 | Allianz Asset Management GmbH | 76,810 | 1,908,000 | 0.38% | ||
| 43 | BlackRock Investment Management, LLC | 76,126 | 1,891,000 | 0.37% | ||
| 44 | CREDIT SUISSE AG/ | 58,597 | 1,456,000 | 0.29% | ||
| 45 | PRUDENTIAL FINANCIAL INC | 51,900 | 1,289,000 | 0.26% | ||
| 46 | Weiss Multi-Strategy Advisers LLC | 50,000 | 1,242,000 | 0.25% | ||
| 47 | Nationwide Fund Advisors | 48,019 | 1,193,000 | 0.24% | ||
| 48 | GOLDMAN SACHS GROUP INC | 43,699 | 1,085,000 | 0.21% | ||
| 49 | OPPENHEIMER & CO INC | 43,503 | 1,080,000 | 0.21% | ||
| 50 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 42,620 | 1,059,000 | 0.21% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
