| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | WELLINGTON MANAGEMENT GROUP LLP | 2,939,612 | 119,437,000 | 12.50% | ||
| 2 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,600,000 | 105,638,000 | 11.06% | ||
| 3 | FMR LLC | 2,269,400 | 92,206,000 | 9.65% | ||
| 4 | EVENTIDE ASSET MANAGEMENT, LLC | 1,155,200 | 46,936,000 | 4.91% | ||
| 5 | Versant Venture Management, LLC | 1,092,152 | 44,374,135 | 4.64% | ||
| 6 | VANGUARD GROUP INC | 1,025,965 | 41,684,000 | 4.36% | ||
| 7 | BlackRock Fund Advisors | 944,434 | 38,372,000 | 4.02% | ||
| 8 | STATE STREET CORP | 823,188 | 33,443,000 | 3.50% | ||
| 9 | DEERFIELD MANAGEMENT COMPANY, L.P. | 680,000 | 27,628,000 | 2.89% | ||
| 10 | RS INVESTMENT MANAGEMENT CO LLC | 594,550 | 24,157,000 | 2.53% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 592,395 | 24,069,000 | 2.52% | ||
| 12 | GREAT POINT PARTNERS LLC | 575,000 | 23,362,000 | 2.45% | ||
| 13 | ACADIAN ASSET MANAGEMENT LLC | 515,957 | 20,966,000 | 2.19% | ||
| 14 | CANADA PENSION PLAN INVESTMENT BOARD | 503,000 | 20,437,000 | 2.14% | ||
| 15 | EcoR1 Capital, LLC | 500,757 | 20,346,000 | 2.13% | ||
| 16 | PERCEPTIVE ADVISORS LLC | 454,129 | 18,451,000 | 1.93% | ||
| 17 | PUTNAM INVESTMENTS LLC | 411,698 | 16,727,000 | 1.75% | ||
| 18 | NORTHERN TRUST CORP | 299,993 | 12,189,000 | 1.28% | ||
| 19 | DRIEHAUS CAPITAL MANAGEMENT LLC | 265,825 | 10,800,000 | 1.13% | ||
| 20 | RENAISSANCE TECHNOLOGIES LLC | 233,300 | 9,479,000 | 0.99% | ||
| 21 | RTW INVESTMENTS, LP | 226,998 | 9,223,000 | 0.97% | ||
| 22 | GEODE CAPITAL MANAGEMENT, LLC | 188,218 | 7,647,000 | 0.80% | ||
| 23 | TEACHERS ADVISORS, LLC | 187,969 | 7,637,000 | 0.80% | ||
| 24 | D. E. Shaw & Co., Inc. | 173,823 | 7,062,000 | 0.74% | ||
| 25 | QVT Financial LP | 170,199 | 6,915,000 | 0.72% | ||
| 26 | LORD, ABBETT & CO. LLC | 161,355 | 6,555,000 | 0.69% | ||
| 27 | WELLS FARGO & COMPANY/MN | 146,545 | 5,953,000 | 0.62% | ||
| 28 | Rock Springs Capital Management LP | 144,500 | 5,871,000 | 0.61% | ||
| 29 | TIAA CREF INVESTMENT MANAGEMENT LLC | 141,867 | 5,764,000 | 0.60% | ||
| 30 | OXFORD ASSET MANAGEMENT LLP | 136,743 | 5,556,000 | 0.58% | ||
| 31 | BARCLAYS PLC | 134,300 | 5,372,000 | 0.56% | Put | |
| 32 | Bank of New York Mellon Corp | 131,367 | 5,338,000 | 0.56% | ||
| 33 | AWM Investment Company, Inc. | 118,199 | 4,802,000 | 0.50% | ||
| 34 | Gotham Asset Management, LLC | 112,967 | 4,590,000 | 0.48% | ||
| 35 | TWO SIGMA INVESTMENTS, LP | 103,169 | 4,192,000 | 0.44% | ||
| 36 | BALYASNY ASSET MANAGEMENT L.P. | 100,250 | 4,073,000 | 0.43% | ||
| 37 | DEUTSCHE BANK AG\ | 94,022 | 3,817,000 | 0.40% | ||
| 38 | GSA CAPITAL PARTNERS LLP | 90,862 | 3,692,000 | 0.39% | ||
| 39 | GOLDMAN SACHS GROUP INC | 87,560 | 3,558,000 | 0.37% | ||
| 40 | BlackRock Investment Management, LLC | 82,443 | 3,350,000 | 0.35% | ||
| 41 | CORNERSTONE CAPITAL MANAGEMENT HOLDINGS LLC. | 81,398 | 3,307,000 | 0.35% | ||
| 42 | SPHERA FUNDS MANAGEMENT LTD. | 80,000 | 3,250,000 | 0.34% | ||
| 43 | GOLDMAN SACHS GROUP INC | 79,300 | 3,222,000 | 0.34% | Put | |
| 44 | Zurcher Kantonalbank (Zurich Cantonalbank) | 74,714 | 3,036,000 | 0.32% | ||
| 45 | Invesco Ltd. | 73,978 | 3,006,000 | 0.31% | ||
| 46 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 69,500 | 2,824,000 | 0.30% | Put | |
| 47 | Allianz Asset Management GmbH | 68,304 | 2,775,000 | 0.29% | ||
| 48 | HBK INVESTMENTS L P | 67,151 | 2,728,000 | 0.29% | ||
| 49 | BARCLAYS PLC | 68,047 | 2,721,000 | 0.28% | ||
| 50 | CREDIT SUISSE AG/ | 60,019 | 2,440,000 | 0.26% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
