| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | WELLINGTON MANAGEMENT GROUP LLP | 3,305,554 | 137,181,000 | 14.70% | ||
| 2 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,325,000 | 96,488,000 | 10.34% | ||
| 3 | EVENTIDE ASSET MANAGEMENT, LLC | 1,255,200 | 52,091,000 | 5.58% | ||
| 4 | Versant Venture Management, LLC | 1,092,152 | 45,324,308 | 4.86% | ||
| 5 | BlackRock Fund Advisors | 928,868 | 38,548,000 | 4.13% | ||
| 6 | VANGUARD GROUP INC | 825,592 | 34,262,000 | 3.67% | ||
| 7 | EcoR1 Capital, LLC | 719,000 | 29,839,000 | 3.20% | ||
| 8 | DEERFIELD MANAGEMENT COMPANY, L.P. | 680,000 | 28,220,000 | 3.02% | ||
| 9 | STATE STREET CORP | 649,350 | 26,950,000 | 2.89% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 614,076 | 25,484,000 | 2.73% | ||
| 11 | GREAT POINT PARTNERS LLC | 569,658 | 23,641,000 | 2.53% | ||
| 12 | RS INVESTMENT MANAGEMENT CO LLC | 511,170 | 21,214,000 | 2.27% | ||
| 13 | CANADA PENSION PLAN INVESTMENT BOARD | 503,000 | 20,875,000 | 2.24% | ||
| 14 | PUTNAM INVESTMENTS LLC | 497,590 | 20,650,000 | 2.21% | ||
| 15 | MILLENNIUM MANAGEMENT LLC | 492,371 | 20,433,000 | 2.19% | ||
| 16 | PERCEPTIVE ADVISORS LLC | 434,129 | 18,016,000 | 1.93% | ||
| 17 | PRICE T ROWE ASSOCIATES INC /MD/ | 318,580 | 13,221,000 | 1.42% | ||
| 18 | RENAISSANCE TECHNOLOGIES LLC | 313,200 | 12,998,000 | 1.39% | ||
| 19 | BVF INC/IL | 300,000 | 12,450,000 | 1.33% | ||
| 20 | DRIEHAUS CAPITAL MANAGEMENT LLC | 297,866 | 12,361,000 | 1.32% | ||
| 21 | NORTHERN TRUST CORP | 297,180 | 12,333,000 | 1.32% | ||
| 22 | CITADEL ADVISORS LLC | 265,967 | 11,037,000 | 1.18% | ||
| 23 | D. E. Shaw & Co., Inc. | 263,018 | 10,916,000 | 1.17% | ||
| 24 | RTW INVESTMENTS, LP | 252,452 | 10,477,000 | 1.12% | ||
| 25 | QVT Financial LP | 246,848 | 10,244,000 | 1.10% | ||
| 26 | MARSHALL WACE, LLP | 237,141 | 9,841,000 | 1.05% | ||
| 27 | BALYASNY ASSET MANAGEMENT L.P. | 225,802 | 9,371,000 | 1.00% | ||
| 28 | GEODE CAPITAL MANAGEMENT, LLC | 183,539 | 7,616,000 | 0.82% | ||
| 29 | GOLDMAN SACHS GROUP INC | 179,838 | 7,464,000 | 0.80% | ||
| 30 | TEACHERS ADVISORS, LLC | 157,566 | 6,539,000 | 0.70% | ||
| 31 | DEUTSCHE BANK AG\ | 156,015 | 6,472,000 | 0.69% | ||
| 32 | LORD, ABBETT & CO. LLC | 152,426 | 6,326,000 | 0.68% | ||
| 33 | SPHERA FUNDS MANAGEMENT LTD. | 145,000 | 6,018,000 | 0.64% | ||
| 34 | TIAA CREF INVESTMENT MANAGEMENT LLC | 139,996 | 5,810,000 | 0.62% | ||
| 35 | SENZAR ASSET MANAGEMENT, LLC | 135,535 | 5,624,703 | 0.60% | ||
| 36 | Rock Springs Capital Management LP | 135,000 | 5,603,000 | 0.60% | ||
| 37 | BARCLAYS PLC | 134,300 | 5,506,000 | 0.59% | Put | |
| 38 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 125,200 | 5,196,000 | 0.56% | Put | |
| 39 | Bank of New York Mellon Corp | 121,932 | 5,061,000 | 0.54% | ||
| 40 | AWM Investment Company, Inc. | 118,199 | 4,905,000 | 0.53% | ||
| 41 | WELLS FARGO & COMPANY/MN | 116,488 | 4,834,000 | 0.52% | ||
| 42 | Candriam S.C.A. | 111,300 | 4,619,000 | 0.50% | ||
| 43 | Ghost Tree Capital, LLC | 100,000 | 4,150,000 | 0.44% | ||
| 44 | AQR CAPITAL MANAGEMENT LLC | 86,483 | 3,589,000 | 0.38% | ||
| 45 | BlackRock Investment Management, LLC | 77,722 | 3,225,000 | 0.35% | ||
| 46 | Allianz Asset Management GmbH | 77,017 | 3,196,000 | 0.34% | ||
| 47 | HBK INVESTMENTS L P | 75,400 | 3,129,000 | 0.34% | ||
| 48 | GSA CAPITAL PARTNERS LLP | 72,200 | 2,996,000 | 0.32% | ||
| 49 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 66,477 | 2,758,000 | 0.30% | ||
| 50 | BLACKROCK ADVISORS LLC | 56,921 | 2,362,000 | 0.25% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
